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ENZYME entry: EC 2.7.11.19

Accepted Name
Phosphorylase kinase.
Alternative Name(s)
Dephosphophosphorylase kinase.
Glycogen phosphorylase kinase.
PHK.
Phosphorylase b kinase.
Phosphorylase B kinase.
Phosphorylase kinase (phosphorylating).
Reaction catalysed
2 ATP + phosphorylase b <=> 2 ADP + phosphorylase a
Cofactor(s)
Ca(2+).
Comment(s)
  • Requires calmodulin for activity.
  • The enzyme phosphorylates a specific serine residue in each of the subunits of the dimeric phosphorylase b.
  • For muscle phosphorylase but not liver phosphorylase, this is accompanied by a further dimerization to form a tetrameric phosphorylase.
  • The enzyme couples muscle contraction with energy production via glycogenolysis--glycolysis by catalyzing the Ca(2+)-dependent phosphorylation and activation of glycogen phosphorylase b.
  • The gamma subunit of the tetrameric alpha-beta-gamma-delta enzyme is the catalytic subunit.
  • Formerly EC 2.7.1.38.
Cross-references
PROSITEPDOC00100
BRENDA2.7.11.19
EC2PDB2.7.11.19
ExplorEnz2.7.11.19
PRIAM enzyme-specific profiles2.7.11.19
KEGG Ligand Database for Enzyme Nomenclature2.7.11.19
IUBMB Enzyme Nomenclature2.7.11.19
IntEnz2.7.11.19
MEDLINEFind literature relating to 2.7.11.19
MetaCyc2.7.11.19
UniProtKB/Swiss-Prot
Q16816, PHKG1_HUMAN;  P07934, PHKG1_MOUSE;  P00518, PHKG1_RABIT;  
P13286, PHKG1_RAT;  Q2KJ16, PHKG2_BOVIN;  P15735, PHKG2_HUMAN;  
Q9DB30, PHKG2_MOUSE;  P31325, PHKG2_RAT;  

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