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ENZYME entry: EC 2.7.11.2

Accepted Name
[Pyruvate dehydrogenase (acetyl-transferring)] kinase.
Alternative Name(s)
PDH kinase.
PDHK.
PDK.
Pyruvate dehydrogenase kinase.
Pyruvate dehydrogenase kinase (phosphorylating).
Reaction catalysed
ATP + [pyruvate dehydrogenase (acetyl-transferring)] <=> ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate
Comment(s)
  • Has no activating compound but is specific for its substrate.
  • A mitochondrial enzyme associated with the pyruvate dehydrogenase complex in mammals.
  • Phosphorylation inactivates EC 1.2.4.1.
  • Formerly EC 2.7.1.99.
Cross-references
PROSITEPDOC50109
BRENDA2.7.11.2
EC2PDB2.7.11.2
ExplorEnz2.7.11.2
PRIAM enzyme-specific profiles2.7.11.2
KEGG Ligand Database for Enzyme Nomenclature2.7.11.2
IUBMB Enzyme Nomenclature2.7.11.2
IntEnz2.7.11.2
MEDLINEFind literature relating to 2.7.11.2
MetaCyc2.7.11.2
UniProtKB/Swiss-Prot
Q02332, PDHK2_CAEEL;  Q15118, PDK1_HUMAN;  Q8BFP9, PDK1_MOUSE;  
Q63065, PDK1_RAT;  P40530, PDK1_YEAST;  Q15119, PDK2_HUMAN;  
Q9JK42, PDK2_MOUSE;  Q64536, PDK2_RAT;  P53170, PDK2_YEAST;  
Q15120, PDK3_HUMAN;  Q922H2, PDK3_MOUSE;  Q16654, PDK4_HUMAN;  
O88345, PDK4_ICTTR;  O70571, PDK4_MOUSE;  O54937, PDK4_RAT;  
Q1KMR4, PDK4_RHIFE;  Q9SBJ1, PDK_ARATH;  O02623, PDK_ASCSU;  
P91622, PDK_DROME;  Q9P6P9, PDK_SCHPO;  

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