ENZYME entry: EC 2.7.11.2
| Accepted Name |
|---|
| [Pyruvate dehydrogenase (acetyl-transferring)] kinase.
|
| Alternative Name(s) |
|---|
| PDH kinase. |
| PDHK. |
| PDK. |
| Pyruvate dehydrogenase kinase. |
| Pyruvate dehydrogenase kinase (phosphorylating). |
| Reaction catalysed |
|---|
| ATP + [pyruvate dehydrogenase (acetyl-transferring)] <=> ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate |
| Comment(s) |
|---|
- Has no activating compound but is specific for its substrate.
- A mitochondrial enzyme associated with the pyruvate dehydrogenase
complex in mammals.
- Phosphorylation inactivates EC 1.2.4.1.
- Formerly EC 2.7.1.99.
|
| Cross-references |
|---|
| PROSITE | PDOC50109 |
| BRENDA | 2.7.11.2 |
| EC2PDB | 2.7.11.2 |
| ExplorEnz | 2.7.11.2 |
| PRIAM enzyme-specific profiles | 2.7.11.2 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.7.11.2 |
| IUBMB Enzyme Nomenclature | 2.7.11.2 |
| IntEnz | 2.7.11.2 |
| MEDLINE | Find literature relating to 2.7.11.2 |
| MetaCyc | 2.7.11.2 |
| UniProtKB/Swiss-Prot |
| Q02332, PDHK2_CAEEL; | Q15118, PDK1_HUMAN; | Q8BFP9, PDK1_MOUSE; |
| Q63065, PDK1_RAT; | Q15119, PDK2_HUMAN; | Q9JK42, PDK2_MOUSE; |
| Q64536, PDK2_RAT; | Q15120, PDK3_HUMAN; | Q922H2, PDK3_MOUSE; |
| Q16654, PDK4_HUMAN; | O70571, PDK4_MOUSE; | O54937, PDK4_RAT; |
| Q1KMR4, PDK4_RHIFE; | O88345, PDK4_SPETR; | Q9SBJ1, PDK_ARATH; |
| O02623, PDK_ASCSU; | P91622, PDK_DROME; | Q9P6P9, PDK_SCHPO; |
| P40530, PDK_YEAST; | P53170, PKP2_YEAST; |
|
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