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ENZYME entry: EC 2.7.11.20

Accepted Name
[Elongation factor 2] kinase.
Alternative Name(s)
Ca/CaM-kinase III.
Calmodulin-dependent protein kinase III.
CaM kinase III.
EEF2 kinase.
EEF2K.
EF2K.
Reaction catalysed
ATP + [elongation factor 2] <=> ADP + [elongation factor 2] phosphate
Cofactor(s)
Ca(2+).
Comment(s)
  • Requires calmodulin for activity.
  • Can also be phosphorylated by the catalytic subunit of EC 2.7.11.11.
  • Elongation factor 2 is phosphorylated in several cell types in response to various growth factors, hormones and other stimuli that raise intracellular Ca(2+).
Cross-references
PROSITEPDOC51158
BRENDA2.7.11.20
EC2PDB2.7.11.20
ExplorEnz2.7.11.20
PRIAM enzyme-specific profiles2.7.11.20
KEGG Ligand Database for Enzyme Nomenclature2.7.11.20
IUBMB Enzyme Nomenclature2.7.11.20
IntEnz2.7.11.20
MEDLINEFind literature relating to 2.7.11.20
MetaCyc2.7.11.20
UniProtKB/Swiss-Prot
O01991, EF2K_CAEEL;  O00418, EF2K_HUMAN;  O08796, EF2K_MOUSE;  
P70531, EF2K_RAT;  

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