ID 2.7.11.21 DE polo kinase. AN PLK. AN polo-like kinase. AN polo serine-threonine kinase. CA (1) ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]. CA (2) ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl- CA [protein]. CC -!- The enzyme associates with the spindle pole during mitosis and is CC thought to play an important role in the dynamic function of the CC mitotic spindle during chromosome segregation. CC -!- The human form of the enzyme, Plk1, does not phosphorylate histone CC H1, enolase and phosvitin but it can phosphorylate myelin basic CC protein and microtubule-associated protein MAP-2, although to a CC lesser extent than casein. CC -!- Formerly EC 2.7.1.37. DR P0C8M8, CCR1_MAIZE ; Q8SWM6, CDC5_ENCCU ; P32562, CDC5_YEAST ; DR Q2TA25, PLK1_BOVIN ; P34331, PLK1_CAEEL ; P53350, PLK1_HUMAN ; DR Q07832, PLK1_MOUSE ; Q62673, PLK1_RAT ; P70032, PLK1_XENLA ; DR P62205, PLK1_XENTR ; Q9N2L7, PLK2_CAEEL ; Q9NYY3, PLK2_HUMAN ; DR P53351, PLK2_MOUSE ; Q5R4L1, PLK2_PONAB ; Q9R012, PLK2_RAT ; DR Q20845, PLK3_CAEEL ; Q9H4B4, PLK3_HUMAN ; Q60806, PLK3_MOUSE ; DR Q9R011, PLK3_RAT ; Q16W24, PLK4_AEDAE ; A2VDZ4, PLK4_BOVIN ; DR B0WAU8, PLK4_CULQU ; Q7ZVS3, PLK4_DANRE ; B3M6I4, PLK4_DROAN ; DR B3NE99, PLK4_DROER ; B4J3F1, PLK4_DROGR ; O97143, PLK4_DROME ; DR B4KYX8, PLK4_DROMO ; B4HBU3, PLK4_DROPE ; Q2LYK3, PLK4_DROPS ; DR B4IAQ8, PLK4_DROSE ; B4QK53, PLK4_DROSI ; B4LDJ6, PLK4_DROVI ; DR B4MXR8, PLK4_DROWI ; B4PDM5, PLK4_DROYA ; O00444, PLK4_HUMAN ; DR Q64702, PLK4_MOUSE ; A7SNN5, PLK4_NEMVE ; Q5R9Z7, PLK4_PONAB ; DR B2GUY1, PLK4_RAT ; Q6PAD2, PLK4_XENLA ; B3DL84, PLK4_XENTR ; DR A8BPK8, PLK_GIAIC ; P50528, PLO1_SCHPO ; P52304, POLO_DROME ; //