ENZYME entry: EC 2.7.11.22

Accepted Name
Cyclin-dependent kinase.
Alternative Name(s)
Cdc2 kinase.
Cdk-activating kinase.
Cdk-activating protein kinase.
Reaction catalysed
ATP + a protein <=> ADP + a phosphoprotein
Comment(s)
  • Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin.
  • It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation.
  • Formerly EC 2.7.1.37.
Cross-references
PROSITEPDOC00100
BRENDA2.7.11.22
EC2PDB2.7.11.22
ExplorEnz2.7.11.22
PRIAM enzyme-specific profiles2.7.11.22
KEGG Ligand Database for Enzyme Nomenclature2.7.11.22
IUBMB Enzyme Nomenclature2.7.11.22
IntEnz2.7.11.22
MEDLINEFind literature relating to 2.7.11.22
MetaCyc2.7.11.22
UniProtKB/Swiss-Prot
Q75D46, BUR1_ASHGO;  Q4WTN5, BUR1_ASPFU;  Q9Y7W4, BUR1_CANAL;  
Q6FQ83, BUR1_CANGA;  Q6BV06, BUR1_DEBHA;  Q96VK3, BUR1_EMENI;  
Q4I5U9, BUR1_GIBZE;  Q6CRA9, BUR1_KLULA;  Q871M9, BUR1_NEUCR;  
Q6C842, BUR1_YARLI;  P23293, BUR1_YEAST;  P43568, CAK1_YEAST;  
P38973, CC2H1_TRYBB;  P54664, CC2H1_TRYCO;  P54665, CC2H2_TRYBB;  
P54666, CC2H3_TRYBB;  Q9UQ88, CD11A_HUMAN;  P21127, CD11B_HUMAN;  
P24788, CD11B_MOUSE;  P46892, CD11B_RAT;  P24923, CDC21_MEDSA;  
P19026, CDC21_PEA;  Q05006, CDC22_MEDSA;  P28567, CDC22_PEA;  
Q38772, CDC2A_ANTMA;  Q38773, CDC2B_ANTMA;  Q38774, CDC2C_ANTMA;  
P23573, CDC2C_DROME;  Q38775, CDC2D_ANTMA;  Q01917, CDC2H_CRIFA;  
Q4Z6R1, CDC2H_PLABA;  Q4Y4B1, CDC2H_PLACH;  P61075, CDC2H_PLAF7;  
Q07785, CDC2H_PLAFK;  O96821, CDC2H_PLAKH;  Q9XZD6, CDC2H_PLAVI;  
Q7RM49, CDC2H_PLAYO;  Q26671, CDC2H_THEAN;  Q27032, CDC2H_THEPA;  
P23111, CDC2_MAIZE;  P93101, CDC2_OXYRB;  P43290, CDC2_PETHY;  
Q41639, CDC2_VIGAC;  P52389, CDC2_VIGUN;  Q2TBL8, CDK10_BOVIN;  
Q55GS4, CDK10_DICDI;  Q15131, CDK10_HUMAN;  Q3UMM4, CDK10_MOUSE;  
Q4KM47, CDK10_RAT;  Q54RB2, CDK11_DICDI;  D2H526, CDK12_AILME;  
E1BB50, CDK12_BOVIN;  P46551, CDK12_CAEEL;  Q9VP22, CDK12_DROME;  
Q9NYV4, CDK12_HUMAN;  Q14AX6, CDK12_MOUSE;  Q3MJK5, CDK12_RAT;  
B5DE93, CDK12_XENTR;  E1BB52, CDK13_BOVIN;  Q14004, CDK13_HUMAN;  
Q69ZA1, CDK13_MOUSE;  B0VXE8, CDK14_CALJA;  B0VXL7, CDK14_CALMO;  
C0RW22, CDK14_DASNO;  O94921, CDK14_HUMAN;  O35495, CDK14_MOUSE;  
B6A7Q3, CDK14_RABIT;  Q6DJM7, CDK14_XENLA;  A4IIW7, CDK14_XENTR;  
Q1RLU9, CDK15_DANRE;  Q96Q40, CDK15_HUMAN;  Q3V3A1, CDK15_MOUSE;  
Q00536, CDK16_HUMAN;  Q04735, CDK16_MOUSE;  Q63686, CDK16_RAT;  
Q00537, CDK17_HUMAN;  Q8K0D0, CDK17_MOUSE;  O35831, CDK17_RAT;  
Q07002, CDK18_HUMAN;  Q04899, CDK18_MOUSE;  Q5RD01, CDK18_PONAB;  
Q9BWU1, CDK19_HUMAN;  Q8BWD8, CDK19_MOUSE;  P35567, CDK1A_XENLA;  
P24033, CDK1B_XENLA;  P54119, CDK1_AJECA;  P48734, CDK1_BOVIN;  
A8XA58, CDK1_CAEBR;  P34556, CDK1_CAEEL;  P43063, CDK1_CANAL;  
P51958, CDK1_CARAU;  P13863, CDK1_CHICK;  P34112, CDK1_DICDI;  
P23572, CDK1_DROME;  Q00646, CDK1_EMENI;  Q8SR86, CDK1_ENCCU;  
P06493, CDK1_HUMAN;  P11440, CDK1_MOUSE;  Q9DGA5, CDK1_ORYCU;  
Q9DGA2, CDK1_ORYJA;  Q9DGD3, CDK1_ORYLA;  Q9DG98, CDK1_ORYLU;  
Q5RCH1, CDK1_PONAB;  Q9W739, CDK1_RANDY;  P39951, CDK1_RAT;  
P04551, CDK1_SCHPO;  P00546, CDK1_YEAST;  A8WIP6, CDK20_DANRE;  
Q8IZL9, CDK20_HUMAN;  Q5EDC3, CDK20_MACMU;  Q9JHU3, CDK20_MOUSE;  
Q5R7I7, CDK20_PONAB;  Q4KM34, CDK20_RAT;  Q5E9Y0, CDK2_BOVIN;  
P43450, CDK2_CARAU;  O55076, CDK2_CRIGR;  Q04770, CDK2_ENTHI;  
P24941, CDK2_HUMAN;  P48963, CDK2_MESAU;  P97377, CDK2_MOUSE;  
Q63699, CDK2_RAT;  P23437, CDK2_XENLA;  Q00526, CDK3_HUMAN;  
Q80YP0, CDK3_MOUSE;  Q32KY4, CDK4_BOVIN;  P11802, CDK4_HUMAN;  
P30285, CDK4_MOUSE;  P79432, CDK4_PIG;  P35426, CDK4_RAT;  
B2MVY4, CDK4_SHEEP;  Q91727, CDK4_XENLA;  P34117, CDK5_DICDI;  
P48609, CDK5_DROME;  Q2PQN9, CDK5_GLOMM;  Q00534, CDK6_HUMAN;  
Q64261, CDK6_MOUSE;  P51953, CDK7_CARAU;  P54685, CDK7_DICDI;  
P50613, CDK7_HUMAN;  Q03147, CDK7_MOUSE;  P51952, CDK7_RAT;  
P20911, CDK7_XENLA;  Q17IE8, CDK8_AEDAE;  P0C661, CDK8_CAEBR;  
P90866, CDK8_CAEEL;  Q8JH47, CDK8_DANRE;  Q95YH0, CDK8_DICDI;  
Q9VT57, CDK8_DROME;  P49336, CDK8_HUMAN;  Q8R3L8, CDK8_MOUSE;  
Q66KH9, CDK8_XENLA;  Q6P3N6, CDK8_XENTR;  Q4V862, CDK9A_XENLA;  
Q7ZX42, CDK9B_XENLA;  Q5EAB2, CDK9_BOVIN;  Q9TVL3, CDK9_CAEEL;  
Q5ZKN1, CDK9_CHICK;  P50750, CDK9_HUMAN;  Q99J95, CDK9_MOUSE;  
Q641Z4, CDK9_RAT;  Q96WV9, CDK9_SCHPO;  Q6GLD8, CDK9_XENTR;  
P24100, CDKA1_ARATH;  P29618, CDKA1_ORYSJ;  P29619, CDKA2_ORYSJ;  
Q9LFT8, CDKC1_ARATH;  Q6I5Y0, CDKC1_ORYSJ;  Q8W4P1, CDKC2_ARATH;  
Q5JK68, CDKC2_ORYSJ;  Q6ZAG3, CDKC3_ORYSJ;  Q9C9U2, CDKD1_ARATH;  
A2Y4B6, CDKD1_ORYSI;  P29620, CDKD1_ORYSJ;  Q9C9M7, CDKD2_ARATH;  
Q9LMT0, CDKD3_ARATH;  Q84TI6, CDKE1_ARATH;  Q336M2, CDKE1_ORYSJ;  
O80345, CDKF1_ARATH;  A2YCH5, CDKF1_ORYSI;  Q5Z754, CDKF1_ORYSJ;  
Q2QSL4, CDKF2_ORYSJ;  Q84SN3, CDKF3_ORYSJ;  Q6Z8C8, CDKF4_ORYSJ;  
Q9FGW5, CDKG1_ARATH;  A2X6X1, CDKG1_ORYSI;  Q6K5F8, CDKG1_ORYSJ;  
A2XUW1, CDKG2_ORYSI;  Q7XUF4, CDKG2_ORYSJ;  Q6AXJ9, CDKL1_DANRE;  
Q00532, CDKL1_HUMAN;  Q8CEQ0, CDKL1_MOUSE;  Q66HE7, CDKL1_RAT;  
Q92772, CDKL2_HUMAN;  Q4R7T5, CDKL2_MACFA;  Q9QUK0, CDKL2_MOUSE;  
Q5R754, CDKL2_PONAB;  Q9TTK0, CDKL2_RABIT;  Q5XIT0, CDKL2_RAT;  
Q8IVW4, CDKL3_HUMAN;  Q4R8T9, CDKL3_MACFA;  Q8BLF2, CDKL3_MOUSE;  
Q9JM01, CDKL3_RAT;  Q5MAI5, CDKL4_HUMAN;  Q3TZA2, CDKL4_MOUSE;  
O76039, CDKL5_HUMAN;  Q3UTQ8, CDKL5_MOUSE;  P25859, CKB11_ARATH;  
Q8L4P8, CKB11_ORYSJ;  Q2V419, CKB12_ARATH;  Q8LF80, CKB21_ARATH;  
Q0J4I1, CKB21_ORYSJ;  Q8LG64, CKB22_ARATH;  O35832, CKD18_RAT;  
P36615, CSK1_SCHPO;  Q9UPZ9, ICK_HUMAN;  Q9JKV2, ICK_MOUSE;  
Q62726, ICK_RAT;  Q9VPC0, KP58_DROME;  P20794, MAK_HUMAN;  
Q04859, MAK_MOUSE;  P20793, MAK_RAT;  P43294, MHK_ARATH;  
Q9UQ07, MOK_HUMAN;  Q9WVS4, MOK_MOUSE;  O74456, PEF1_SCHPO;  
Q751E8, PHO85_ASHGO;  Q9HGY5, PHO85_CANAX;  Q6FKD4, PHO85_CANGA;  
Q6BRY2, PHO85_DEBHA;  Q92241, PHO85_KLULA;  Q6C7U8, PHO85_YARLI;  
P17157, PHO85_YEAST;  Q12706, PSK1_SCHPO;  Q751F5, SSN3_ASHGO;  
A1CL96, SSN3_ASPCL;  Q4WYR6, SSN3_ASPFU;  A2QU77, SSN3_ASPNC;  
Q2UC58, SSN3_ASPOR;  Q0CQK1, SSN3_ASPTN;  Q5AHK2, SSN3_CANAL;  
Q6FKC6, SSN3_CANGA;  Q2GYV9, SSN3_CHAGB;  Q1EBK0, SSN3_COCIM;  
P0CS77, SSN3_CRYNB;  P0CS76, SSN3_CRYNJ;  Q6BM25, SSN3_DEBHA;  
Q5BAE1, SSN3_EMENI;  Q4FCZ5, SSN3_GIBMO;  Q6CR51, SSN3_KLULA;  
A4QXX4, SSN3_MAGO7;  A1D624, SSN3_NEOFI;  Q0TWJ7, SSN3_PHANO;  
A3LUB9, SSN3_PICST;  O13958, SSN3_SCHPO;  Q4P9T2, SSN3_USTMA;  
Q6CCB0, SSN3_YARLI;  P39073, SSN3_YEAST;  Q54D75, Y2550_DICDI;  
Q556J6, Y4007_DICDI;  Q55FJ6, Y8078_DICDI;  Q8SRF5, Y823_ENCCU;  
Q54Y06, Y8487_DICDI;  Q8SR90, Y8H9_ENCCU;  Q8SQU8, YBC9_ENCCU;  

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