ENZYME entry: EC 2.7.11.23

Accepted Name
[RNA-polymerase]-subunit kinase.
Alternative Name(s)
CTD kinase.
Reaction catalysed
ATP + [DNA-directed RNA polymerase] <=> ADP + [DNA-directed RNA polymerase] phosphate
Comment(s)
  • Appears to be distinct from other protein phosphokinases.
  • Brings about multiple phosphorylation of the unique C-terminal repeat domain of the largest subunit of eukaryotic EC 2.7.7.6.
  • Does not phosphorylate casein, phosvitin or histone.
  • Formerly EC 2.7.1.141.
Cross-references
PROSITEPDOC00100
BRENDA2.7.11.23
EC2PDB2.7.11.23
ExplorEnz2.7.11.23
PRIAM enzyme-specific profiles2.7.11.23
KEGG Ligand Database for Enzyme Nomenclature2.7.11.23
IUBMB Enzyme Nomenclature2.7.11.23
IntEnz2.7.11.23
MEDLINEFind literature relating to 2.7.11.23
MetaCyc2.7.11.23
UniProtKB/Swiss-Prot
Q75D46, BUR1_ASHGO;  Q4WTN5, BUR1_ASPFU;  Q9Y7W4, BUR1_CANAL;  
Q6FQ83, BUR1_CANGA;  Q6BV06, BUR1_DEBHA;  Q96VK3, BUR1_EMENI;  
Q4I5U9, BUR1_GIBZE;  Q6CRA9, BUR1_KLULA;  Q871M9, BUR1_NEUCR;  
Q6C842, BUR1_YARLI;  P23293, BUR1_YEAST;  P24923, CDC21_MEDSA;  
P19026, CDC21_PEA;  P28567, CDC22_PEA;  Q38772, CDC2A_ANTMA;  
Q38773, CDC2B_ANTMA;  Q38774, CDC2C_ANTMA;  P23573, CDC2C_DROME;  
Q38775, CDC2D_ANTMA;  Q01917, CDC2H_CRIFA;  Q4Z6R1, CDC2H_PLABA;  
Q4Y4B1, CDC2H_PLACH;  P61075, CDC2H_PLAF7;  Q07785, CDC2H_PLAFK;  
O96821, CDC2H_PLAKH;  Q9XZD6, CDC2H_PLAVI;  Q7RM49, CDC2H_PLAYO;  
Q26671, CDC2H_THEAN;  Q27032, CDC2H_THEPA;  P23111, CDC2_MAIZE;  
P93101, CDC2_OXYRB;  P43290, CDC2_PETHY;  Q41639, CDC2_VIGAC;  
P52389, CDC2_VIGUN;  D2H526, CDK12_AILME;  E1BB50, CDK12_BOVIN;  
P46551, CDK12_CAEEL;  Q9VP22, CDK12_DROME;  Q9NYV4, CDK12_HUMAN;  
Q14AX6, CDK12_MOUSE;  Q3MJK5, CDK12_RAT;  B5DE93, CDK12_XENTR;  
E1BB52, CDK13_BOVIN;  Q14004, CDK13_HUMAN;  Q69ZA1, CDK13_MOUSE;  
P35567, CDK1A_XENLA;  P24033, CDK1B_XENLA;  P54119, CDK1_AJECA;  
P48734, CDK1_BOVIN;  A8XA58, CDK1_CAEBR;  P34556, CDK1_CAEEL;  
P51958, CDK1_CARAU;  P13863, CDK1_CHICK;  P34112, CDK1_DICDI;  
P23572, CDK1_DROME;  Q00646, CDK1_EMENI;  P06493, CDK1_HUMAN;  
P11440, CDK1_MOUSE;  Q9DGA5, CDK1_ORYCU;  Q9DGA2, CDK1_ORYJA;  
Q9DGD3, CDK1_ORYLA;  Q9DG98, CDK1_ORYLU;  Q5RCH1, CDK1_PONAB;  
Q9W739, CDK1_RANDY;  P39951, CDK1_RAT;  P04551, CDK1_SCHPO;  
P51953, CDK7_CARAU;  P54685, CDK7_DICDI;  P50613, CDK7_HUMAN;  
Q03147, CDK7_MOUSE;  P51952, CDK7_RAT;  P20911, CDK7_XENLA;  
Q17IE8, CDK8_AEDAE;  P0C661, CDK8_CAEBR;  P90866, CDK8_CAEEL;  
Q8JH47, CDK8_DANRE;  Q95YH0, CDK8_DICDI;  Q9VT57, CDK8_DROME;  
P49336, CDK8_HUMAN;  Q8R3L8, CDK8_MOUSE;  Q66KH9, CDK8_XENLA;  
Q6P3N6, CDK8_XENTR;  Q4V862, CDK9A_XENLA;  Q7ZX42, CDK9B_XENLA;  
Q5EAB2, CDK9_BOVIN;  Q9TVL3, CDK9_CAEEL;  Q5ZKN1, CDK9_CHICK;  
P50750, CDK9_HUMAN;  Q99J95, CDK9_MOUSE;  Q641Z4, CDK9_RAT;  
Q96WV9, CDK9_SCHPO;  Q6GLD8, CDK9_XENTR;  P24100, CDKA1_ARATH;  
P29618, CDKA1_ORYSJ;  P29619, CDKA2_ORYSJ;  Q9LFT8, CDKC1_ARATH;  
Q6I5Y0, CDKC1_ORYSJ;  Q8W4P1, CDKC2_ARATH;  Q5JK68, CDKC2_ORYSJ;  
Q6ZAG3, CDKC3_ORYSJ;  Q9C9U2, CDKD1_ARATH;  A2Y4B6, CDKD1_ORYSI;  
P29620, CDKD1_ORYSJ;  Q9C9M7, CDKD2_ARATH;  Q9LMT0, CDKD3_ARATH;  
Q84TI6, CDKE1_ARATH;  Q336M2, CDKE1_ORYSJ;  O80345, CDKF1_ARATH;  
A2YCH5, CDKF1_ORYSI;  Q5Z754, CDKF1_ORYSJ;  Q2QSL4, CDKF2_ORYSJ;  
Q84SN3, CDKF3_ORYSJ;  Q6Z8C8, CDKF4_ORYSJ;  A2X6X1, CDKG1_ORYSI;  
Q6K5F8, CDKG1_ORYSJ;  A2XUW1, CDKG2_ORYSI;  Q7XUF4, CDKG2_ORYSJ;  
P25859, CKB11_ARATH;  Q8L4P8, CKB11_ORYSJ;  Q2V419, CKB12_ARATH;  
Q8LF80, CKB21_ARATH;  Q0J4I1, CKB21_ORYSJ;  Q8LG64, CKB22_ARATH;  
Q06309, CRK1_LEIME;  Q12126, CRK1_SCHPO;  Q8SQW2, CTK1_ENCCU;  
O14098, CTK1_SCHPO;  Q03957, CTK1_YEAST;  Q8SW92, KIN28_ENCCU;  
P06242, KIN28_YEAST;  Q751F5, SSN3_ASHGO;  A1CL96, SSN3_ASPCL;  
Q4WYR6, SSN3_ASPFU;  A2QU77, SSN3_ASPNC;  Q2UC58, SSN3_ASPOR;  
Q0CQK1, SSN3_ASPTN;  Q5AHK2, SSN3_CANAL;  Q6FKC6, SSN3_CANGA;  
Q2GYV9, SSN3_CHAGB;  Q1EBK0, SSN3_COCIM;  P0CS77, SSN3_CRYNB;  
P0CS76, SSN3_CRYNJ;  Q6BM25, SSN3_DEBHA;  Q5BAE1, SSN3_EMENI;  
Q4FCZ5, SSN3_GIBMO;  Q6CR51, SSN3_KLULA;  A4QXX4, SSN3_MAGO7;  
A1D624, SSN3_NEOFI;  Q0TWJ7, SSN3_PHANO;  A3LUB9, SSN3_PICST;  
O13958, SSN3_SCHPO;  Q4P9T2, SSN3_USTMA;  Q6CCB0, SSN3_YARLI;  
P39073, SSN3_YEAST;  

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