ID   2.7.11.24
DE   mitogen-activated protein kinase.
AN   c-Jun N-terminal kinase.
AN   ERK.
AN   extracellular signal-regulated kinase.
AN   JNK.
AN   MAPK.
AN   MAP kinase.
AN   MBP kinase I.
AN   MBP kinase II.
AN   microtubule-associated protein 2 kinase.
AN   microtubule-associated protein kinase.
AN   myelin basic protein kinase.
AN   SAPK.
AN   stress-activated protein kinase.
CA   (1) L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).
CA   (2) L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP +
CA   H(+).
CC   -!- Phosphorylation of specific tyrosine and threonine residues in the
CC       activation loop of this enzyme by EC 2.7.12.2 is necessary for enzyme
CC       activation.
CC   -!- Once activated, the enzyme phosphorylates target substrates on serine
CC       or threonine residues followed by a proline.
CC   -!- A distinguishing feature of all MAPKs is the conserved sequence Thr-
CC       Xaa-Tyr (TXY).
CC   -!- Mitogen-activated protein kinase (MAPK) signal transduction pathways
CC       are among the most widespread mechanisms of cellular regulation.
CC   -!- Mammalian MAPK pathways can be recruited by a wide variety of stimuli
CC       including hormones (e.g. insulin and growth hormone), mitogens (e.g.
CC       epidermal growth factor and platelet-derived growth factor),
CC       vasoactive peptides (e.g. angiotensin-II and endothelin),
CC       inflammatory cytokines of the tumor necrosis factor (TNF) family and
CC       environmental stresses such as osmotic shock, ionizing radiation and
CC       ischemeic injury.
CC   -!- Formerly EC 2.7.1.37.
DR   B0XXN8, BCK1_ASPFC ;  Q4WXY0, BCK1_ASPFU ;  P0CP66, CPK1_CRYD1 ;
DR   P0CP67, CPK1_CRYD3 ;  Q5A1D3, ERK1_CANAL ;  C4YGK0, ERK1_CANAW ;
DR   P42525, ERK1_DICDI ;  Q54QB1, ERK2_DICDI ;  Q9W354, ERK7_DROME ;
DR   P40417, ERKA_DROME ;  P16892, FUS3_YEAST ;  A3EZ55, HOG1A_WALI9;
DR   M1T7M3, HOG1B_WALI9;  Q52PH6, HOG1_ALTBR ;  G1XJZ4, HOG1_ARTOA ;
DR   A1CPG7, HOG1_ASPCL ;  Q4WSF6, HOG1_ASPFU ;  Q38HL5, HOG1_ASPGL ;
DR   A2QRF6, HOG1_ASPNC ;  Q0D0P5, HOG1_ASPTN ;  A0A5B9GBF0, HOG1_AURME ;
DR   Q6PWX2, HOG1_BEABA ;  Q702W0, HOG1_BLAAD ;  Q8TGA9, HOG1_BLUGR ;
DR   A1IVT7, HOG1_BOTFB ;  Q92207, HOG1_CANAL ;  Q6FIU2, HOG1_CANGA ;
DR   Q2H332, HOG1_CHAGB ;  Q4W6D3, HOG1_COCHE ;  Q1DUU8, HOG1_COCIM ;
DR   Q2WFL5, HOG1_COCMI ;  Q75Q66, HOG1_COLOR ;  P0CP68, HOG1_CRYD1 ;
DR   P0CP69, HOG1_CRYD3 ;  Q56R42, HOG1_CRYN9 ;  Q875L0, HOG1_CRYPA ;
DR   Q9UV50, HOG1_DEBHA ;  Q9P419, HOG1_EMENI ;  Q750A9, HOG1_EREGS ;
DR   Q5I6M2, HOG1_EXSTU ;  Q4PNJ1, HOG1_FUSCU ;  Q4PKS0, HOG1_GIBIN ;
DR   P0C431, HOG1_GIBZE ;  Q8NJT7, HOG1_HORWE ;  Q6XKY3, HOG1_HYPAT ;
DR   Q6CJA8, HOG1_KLULA ;  Q4PC06, HOG1_MYCMD ;  A1D2C9, HOG1_NEOFI ;
DR   Q96TL5, HOG1_NEUCR ;  Q0U4L8, HOG1_PHANO ;  A3LN91, HOG1_PICST ;
DR   Q9UV51, HOG1_PYRO7 ;  Q09892, HOG1_SCHPO ;  Q1L5Z8, HOG1_TORDE ;
DR   Q2WGK3, HOG1_TRIHA ;  A0A1B5KW97, HOG1_USTVR ;  A3EZ53, HOG1_WALMU ;
DR   A3EZ54, HOG1_WALSE ;  Q6C4M9, HOG1_YARLI ;  P32485, HOG1_YEAST ;
DR   O93982, HOG1_ZYGRC ;  O59854, HOG1_ZYGRO ;  Q1KTF2, HOG1_ZYMTI ;
DR   O59853, HOG2_ZYGRO ;  Q9U6D2, JNK1_ANCCA ;  Q8WQG9, JNK1_CAEEL ;
DR   P92208, JNK_DROME  ;  Q966Y3, JNK_SUBDO  ;  O44408, KGB1_CAEEL ;
DR   P14681, KSS1_YEAST ;  O94737, MAPK1_PNECA;  O42781, MAPK2_PNECA;
DR   S8EUF0, MAPKL_TOXGM;  Q00859, MAPK_FUSVN ;  G4NDR3, MCK1_PYRO7 ;
DR   P46196, MK01_BOVIN ;  P28482, MK01_HUMAN ;  P63085, MK01_MOUSE ;
DR   P63086, MK01_RAT   ;  P26696, MK01_XENLA ;  P27361, MK03_HUMAN ;
DR   Q63844, MK03_MOUSE ;  P21708, MK03_RAT   ;  P31152, MK04_HUMAN ;
DR   Q6P5G0, MK04_MOUSE ;  Q63454, MK04_RAT   ;  Q5F3W3, MK06_CHICK ;
DR   Q16659, MK06_HUMAN ;  Q61532, MK06_MOUSE ;  Q5R7U1, MK06_PONAB ;
DR   P27704, MK06_RAT   ;  A5PKJ4, MK07_BOVIN ;  Q13164, MK07_HUMAN ;
DR   Q9WVS8, MK07_MOUSE ;  P0C865, MK07_RAT   ;  Q90327, MK08A_CYPCA;
DR   O42099, MK08B_CYPCA;  Q9DGD9, MK08_DANRE ;  P45983, MK08_HUMAN ;
DR   Q91Y86, MK08_MOUSE ;  P49185, MK08_RAT   ;  Q8QHK8, MK08_XENLA ;
DR   P79996, MK09_CHICK ;  P45984, MK09_HUMAN ;  Q9WTU6, MK09_MOUSE ;
DR   P49186, MK09_RAT   ;  P53779, MK10_HUMAN ;  Q61831, MK10_MOUSE ;
DR   P49187, MK10_RAT   ;  Q15759, MK11_HUMAN ;  Q9WUI1, MK11_MOUSE ;
DR   O42376, MK12_DANRE ;  P53778, MK12_HUMAN ;  O08911, MK12_MOUSE ;
DR   Q63538, MK12_RAT   ;  Q3T0N5, MK13_BOVIN ;  O15264, MK13_HUMAN ;
DR   Q9Z1B7, MK13_MOUSE ;  Q9N272, MK13_PANTR ;  Q9WTY9, MK13_RAT   ;
DR   Q90336, MK14A_CYPCA;  Q9DGE2, MK14A_DANRE;  Q9I958, MK14B_CYPCA;
DR   Q9DGE1, MK14B_DANRE;  P83100, MK14C_DROME;  O02812, MK14_CANLF ;
DR   Q16539, MK14_HUMAN ;  P47811, MK14_MOUSE ;  Q95NE7, MK14_PANTR ;
DR   P70618, MK14_RAT   ;  P47812, MK14_XENLA ;  Q11179, MK15_CAEEL ;
DR   Q8TD08, MK15_HUMAN ;  Q80Y86, MK15_MOUSE ;  Q9Z2A6, MK15_RAT   ;
DR   Q501Q9, MK15_XENLA ;  Q9LKZ2, MK1_CAPAN  ;  Q9LKZ1, MK2_CAPAN  ;
DR   O62618, MK38A_DROME;  O61443, MK38B_DROME;  Q5AAG6, MKC1_CANAL ;
DR   P43068, MKC1_CANAX ;  A0A194W8T8, MKH1_CYTMA ;  A0A194VNL2, MKK1_CYTMA ;
DR   B0XPE4, MKK2_ASPFC ;  Q4WJJ0, MKK2_ASPFU ;  G4N6Z6, MKK2_PYRO7 ;
DR   Q07176, MMK1_MEDSA ;  Q40353, MMK2_MEDSA ;  O81472, MP3K2_ARATH;
DR   Q9M1Z5, MPK10_ARATH;  Q5ZCI1, MPK10_ORYSJ;  Q9LMM5, MPK11_ARATH;
DR   Q5VN19, MPK11_ORYSJ;  Q8GYQ5, MPK12_ARATH;  Q5Z9J0, MPK12_ORYSJ;
DR   Q9LQQ9, MPK13_ARATH;  A2X0M1, MPK13_ORYSI;  Q0E459, MPK13_ORYSJ;
DR   O23236, MPK14_ARATH;  Q75KK8, MPK14_ORYSJ;  Q9C9U4, MPK15_ARATH;
DR   Q53N72, MPK15_ORYSJ;  Q8W4J2, MPK16_ARATH;  Q5VP69, MPK16_ORYSJ;
DR   Q84M93, MPK17_ARATH;  Q6L5F7, MPK17_ORYSJ;  Q9C5C0, MPK18_ARATH;
DR   Q9LUC3, MPK19_ARATH;  Q39021, MPK1_ARATH ;  P39745, MPK1_CAEEL ;
DR   Q84UI5, MPK1_ORYSJ ;  Q9SJG9, MPK20_ARATH;  Q39022, MPK2_ARATH ;
DR   Q5J4W4, MPK2_ORYSJ ;  Q39023, MPK3_ARATH ;  Q6Z437, MPK3_ORYSJ ;
DR   A9T142, MPK4A_PHYPA;  A9S9Q8, MPK4B_PHYPA;  Q39024, MPK4_ARATH ;
DR   Q9GRU1, MPK4_LEIME ;  Q5Z859, MPK4_ORYSJ ;  Q39025, MPK5_ARATH ;
DR   A2XFC8, MPK5_ORYSI ;  Q10N20, MPK5_ORYSJ ;  Q39026, MPK6_ARATH ;
DR   Q336X9, MPK6_ORYSJ ;  Q39027, MPK7_ARATH ;  Q67C40, MPK7_ORYSJ ;
DR   Q9LM33, MPK8_ARATH ;  Q5SN53, MPK8_ORYSJ ;  Q9LV37, MPK9_ARATH ;
DR   Q6L5D4, MPK9_ORYSJ ;  B0Y4X4, MPKA_ASPFC ;  Q4WQR3, MPKA_ASPFU ;
DR   B0Y8W7, MPKB_ASPFC ;  A1CAF0, MPKC_ASPCL ;  B0Y462, MPKC_ASPFC ;
DR   Q4WUN7, MPKC_ASPFU ;  A2QN07, MPKC_ASPNC ;  Q2U469, MPKC_ASPOR ;
DR   Q0CIC7, MPKC_ASPTN ;  Q9HG11, MPKC_EMENI ;  A1DES4, MPKC_NEOFI ;
DR   Q06060, MPK_PEA    ;  Q40884, MPK_PETHY  ;  G4N374, MPS1_PYRO7 ;
DR   O13352, MPS1_PYROR ;  G4N7X0, MST11_PYRO7;  G4NEB8, MST7_PYRO7 ;
DR   Q8QGV6, NLK2_XENLA ;  B1H3E1, NLK2_XENTR ;  E1BMN8, NLK_BOVIN  ;
DR   A8XSC1, NLK_CAEBR  ;  Q9U9Y8, NLK_CAEEL  ;  E2QWQ2, NLK_CANLF  ;
DR   Q9UBE8, NLK_HUMAN  ;  O54949, NLK_MOUSE  ;  D3ZSZ3, NLK_RAT    ;
DR   Q40517, NTF3_TOBAC ;  Q40532, NTF4_TOBAC ;  Q40531, NTF6_TOBAC ;
DR   Q17446, PMK1_CAEEL ;  A0A423WA64, PMK1_CYTCH ;  G4N0Z0, PMK1_PYRO7 ;
DR   Q92246, PMK1_PYROR ;  Q8MXI4, PMK2_CAEEL ;  O44514, PMK3_CAEEL ;
DR   B0XR80, SAKA_ASPFC ;  Q00772, SLT2_YEAST ;  G5EBT1, SMA5_CAEEL ;
DR   P41808, SMK1_YEAST ;  P27638, SPK1_SCHPO ;  A0A194WDG1, SPM1_CYTMA ;
DR   Q92398, SPM1_SCHPO ;  A0A423V942, STE11_CYTCH;  A0A423VZH2, STE7_CYTCH ;
DR   G9MQI4, TVK1_HYPVG ;
//