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ENZYME entry: EC 2.7.11.26

Accepted Name
[Tau protein] kinase.
Alternative Name(s)
[Tau-protein] kinase.
Glycogen synthase kinase-3-beta.
GSK.
Protein tau kinase.
Tau kinase.
Tau-tubulin kinase.
TPK.
TTK.
Reaction catalysed
ATP + [tau protein] <=> ADP + [tau protein] phosphate
Comment(s)
  • Activated by tubulin.
  • Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease.
  • Formerly EC 2.7.1.135.
Cross-references
PROSITEPDOC00100
BRENDA2.7.11.26
EC2PDB2.7.11.26
ExplorEnz2.7.11.26
PRIAM enzyme-specific profiles2.7.11.26
KEGG Ligand Database for Enzyme Nomenclature2.7.11.26
IUBMB Enzyme Nomenclature2.7.11.26
IntEnz2.7.11.26
MEDLINEFind literature relating to 2.7.11.26
MetaCyc2.7.11.26
UniProtKB/Swiss-Prot
Q13131, AAPK1_HUMAN;  Q5EG47, AAPK1_MOUSE;  Q09136, AAPK1_PIG;  
Q5RDH5, AAPK1_PONAB;  P54645, AAPK1_RAT;  Q8TDC3, BRSK1_HUMAN;  
Q5RJI5, BRSK1_MOUSE;  B2DD29, BRSK1_RAT;  Q8IWQ3, BRSK2_HUMAN;  
Q69Z98, BRSK2_MOUSE;  D3ZML2, BRSK2_RAT;  Q55C57, GLKA_DICDI;  
P49840, GSK3A_HUMAN;  Q2NL51, GSK3A_MOUSE;  P18265, GSK3A_RAT;  
P49841, GSK3B_HUMAN;  Q9WV60, GSK3B_MOUSE;  P18266, GSK3B_RAT;  
Q5YJC2, GSK3B_SPECI;  Q388M1, GSK3B_TRYB2;  Q91757, GSK3B_XENLA;  
P83101, GSK3H_DROME;  A8X5H5, GSK3_CAEBR;  Q9U2Q9, GSK3_CAEEL;  
P51136, GSK3_DICDI;  P35508, KC1D_BOVIN;  P48730, KC1D_HUMAN;  
Q9DC28, KC1D_MOUSE;  Q5RC72, KC1D_PONAB;  Q06486, KC1D_RAT;  
Q9P0L2, MARK1_HUMAN;  Q8VHJ5, MARK1_MOUSE;  O08678, MARK1_RAT;  
Q7KZI7, MARK2_HUMAN;  Q05512, MARK2_MOUSE;  O08679, MARK2_RAT;  
Q16816, PHKG1_HUMAN;  P07934, PHKG1_MOUSE;  P00518, PHKG1_RABIT;  
P13286, PHKG1_RAT;  

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