ENZYME entry: EC 2.7.11.31

Accepted Name
[Hydroxymethylglutaryl-CoA reductase (NADPH)] kinase.
Alternative Name(s)
3-hydroxy-3-methylglutaryl coenzyme A reductase kinase.
3-hydroxy-3-methylglutaryl-CoA reductase kinase.
[Hydroxymethylglutaryl-CoA reductase (NADPH(2))] kinase.
AMP-activated protein kinase.
AMPK.
Beta-hydroxy-beta-methylglutaryl-CoA reductase kinase.
HMG-CoA reductase kinase.
Hydroxymethylglutaryl coenzyme A reductase kinase.
Hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating).
Hydroxymethylglutaryl-CoA reductase kinase.
Reductase kinase.
Reaction catalysed
ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] <=> ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate
Comment(s)
  • Activated by AMP.
  • EC 1.1.1.34 is inactivated by the phosphorylation of the enzyme protein.
  • Histones can also act as acceptors.
  • Can also phosphorylate EC 6.4.1.2 and EC 3.1.1.79.
  • Thr-172 within the catalytic subunit (alpha-subunit) is the major site phosphorylated by the AMP-activated protein kinase kinase.
  • GTP can act instead of ATP.
  • Formerly EC 2.7.1.109.
Cross-references
BRENDA2.7.11.31
EC2PDB2.7.11.31
ExplorEnz2.7.11.31
PRIAM enzyme-specific profiles2.7.11.31
KEGG Ligand Database for Enzyme Nomenclature2.7.11.31
IUBMB Enzyme Nomenclature2.7.11.31
IntEnz2.7.11.31
MEDLINEFind literature relating to 2.7.11.31
MetaCyc2.7.11.31

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.11.-
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