ENZYME entry: EC 2.7.11.7

Accepted Name
[Myosin heavy-chain] kinase.
Alternative Name(s)
Calmodulin-dependent myosin heavy chain kinase.
MHCK.
MIHC kinase.
Myosin heavy chain kinase.
Myosin heavy chain kinase A.
Myosin heavy-chain kinase.
Myosin I heavy-chain kinase.
Myosin II heavy-chain kinase.
Reaction catalysed
ATP + [myosin heavy-chain] <=> ADP + [myosin heavy-chain] phosphate
Comment(s)
  • The enzyme from Dictyostelium sp. (slime molds) brings about phosphorylation of the heavy chains of Dictyostelium myosin, inhibiting the actin-activated ATPase activity of the myosin.
  • One threonine residue in each heavy chain acts as acceptor.
  • While the enzyme from some species is activated by actin, in other cases Ca(2+)/calmodulin are required for activity.
  • Formerly EC 2.7.1.129.
Cross-references
PROSITEPDOC00100 ; PDOC51158
BRENDA2.7.11.7
EC2PDB2.7.11.7
ExplorEnz2.7.11.7
PRIAM enzyme-specific profiles2.7.11.7
KEGG Ligand Database for Enzyme Nomenclature2.7.11.7
IUBMB Enzyme Nomenclature2.7.11.7
IntEnz2.7.11.7
MEDLINEFind literature relating to 2.7.11.7
MetaCyc2.7.11.7
UniProtKB/Swiss-Prot
P42527, MHCKA_DICDI;  P90648, MHCKB_DICDI;  Q8MY12, MHCKC_DICDI;  
Q54SF9, MHCKD_DICDI;  

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