ID 2.7.11.7 DE [myosin heavy-chain] kinase. AN calmodulin-dependent myosin heavy chain kinase. AN MHCK. AN MIHC kinase. AN myosin heavy chain kinase. AN myosin heavy-chain kinase. AN myosin heavy chain kinase A. AN myosin I heavy-chain kinase. AN myosin II heavy-chain kinase. CA ATP + L-threonyl-[myosin heavy-chain] = ADP + H(+) + O-phospho-L- CA threonyl-[myosin heavy-chain]. CC -!- The enzyme from Dictyostelium sp. (slime molds) brings about CC phosphorylation of the heavy chains of Dictyostelium myosin, CC inhibiting the actin-activated ATPase activity of the myosin. CC -!- One threonine residue in each heavy chain acts as acceptor. CC -!- While the enzyme from some species is activated by actin, in other CC cases Ca(2+)/calmodulin are required for activity. CC -!- Formerly EC 2.7.1.129. DR P42527, MHCKA_DICDI; P90648, MHCKB_DICDI; Q8MY12, MHCKC_DICDI; DR Q54SF9, MHCKD_DICDI; //