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ENZYME entry: EC 2.7.12.1

Accepted Name
Dual-specificity kinase.
Reaction catalysed
ATP + a protein <=> ADP + a phosphoprotein
Comment(s)
  • This family of enzymes can phosphorylate both Ser/Thr and Tyr residues.
  • Formerly EC 2.7.1.37.
Cross-references
PROSITEPDOC00100
BRENDA2.7.12.1
EC2PDB2.7.12.1
ExplorEnz2.7.12.1
PRIAM enzyme-specific profiles2.7.12.1
KEGG Ligand Database for Enzyme Nomenclature2.7.12.1
IUBMB Enzyme Nomenclature2.7.12.1
IntEnz2.7.12.1
MEDLINEFind literature relating to 2.7.12.1
MetaCyc2.7.12.1
UniProtKB/Swiss-Prot
P51566, AFC1_ARATH;  P51567, AFC2_ARATH;  P51568, AFC3_ARATH;  
P49759, CLK1_HUMAN;  P22518, CLK1_MOUSE;  P49760, CLK2_HUMAN;  
O35491, CLK2_MOUSE;  Q3SX21, CLK3_BOVIN;  P49761, CLK3_HUMAN;  
O35492, CLK3_MOUSE;  Q63117, CLK3_RAT;  Q9HAZ1, CLK4_HUMAN;  
O35493, CLK4_MOUSE;  P49762, DOA_DROME;  Q1L6Q1, DUSTY_APIME;  
Q4TVR5, DUSTY_BOVIN;  Q4VSN4, DUSTY_CANFA;  Q6XUX0, DUSTY_CHICK;  
Q4VSN1, DUSTY_DANRE;  Q6XUX3, DUSTY_HUMAN;  Q20CR4, DUSTY_MACMU;  
Q6XUX1, DUSTY_MOUSE;  Q4VSN5, DUSTY_PANTR;  A2CI34, DUSTY_PIMPR;  
Q6XUX2, DUSTY_RAT;  A2CI35, DUSTY_STRPU;  Q4VSN2, DUSTY_TAKRU;  
Q4VSN3, DUSTY_TETNG;  Q67E01, DUSTY_XENLA;  Q67E00, DUSTY_XENTR;  
Q13627, DYR1A_HUMAN;  Q61214, DYR1A_MOUSE;  Q2TAE3, DYR1A_XENLA;  
Q0IJ08, DYR1A_XENTR;  Q9Y463, DYR1B_HUMAN;  Q9Z188, DYR1B_MOUSE;  
Q76NV1, DYRK1_DICDI;  Q5ZIU3, DYRK2_CHICK;  Q54BC9, DYRK2_DICDI;  
Q9V3D5, DYRK2_DROME;  Q92630, DYRK2_HUMAN;  Q5U4C9, DYRK2_MOUSE;  
P83102, DYRK3_DROME;  O43781, DYRK3_HUMAN;  Q4R6S5, DYRK3_MACFA;  
Q922Y0, DYRK3_MOUSE;  Q4V8A3, DYRK3_RAT;  Q9NR20, DYRK4_HUMAN;  
Q8BI55, DYRK4_MOUSE;  P32350, KNS1_YEAST;  Q10156, LKH1_SCHPO;  
A8X4H1, MBK1_CAEBR;  Q8WQL7, MBK1_CAEEL;  A8WJR8, MBK2_CAEBR;  
Q9XTF3, MBK2_CAEEL;  P21965, MCK1_YEAST;  P49657, MNB_DROME;  
Q09690, POM1_SCHPO;  Q54I36, PYK3_DICDI;  P22216, RAD53_YEAST;  
Q15569, TESK1_HUMAN;  O70146, TESK1_MOUSE;  Q63572, TESK1_RAT;  
Q96S53, TESK2_HUMAN;  Q8VCT9, TESK2_MOUSE;  Q924U5, TESK2_RAT;  
Q8AYG3, TTK_DANRE;  P33981, TTK_HUMAN;  Q4R945, TTK_MACFA;  
P35761, TTK_MOUSE;  Q8SQZ4, YAK1_ENCCU;  P14680, YAK1_YEAST;  
Q54QV3, YAKA_DICDI;  Q75JK0, ZAK1_DICDI;  Q552C6, ZAK2_DICDI;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.12.-
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