ENZYME entry: EC 2.7.13.3

Accepted Name
Histidine kinase.
Alternative Name(s)
Histidine protein kinase.
HK1.
Protein histidine kinase.
Protein kinase.
Protein kinase (histidine).
Reaction catalysed
ATP + protein L-histidine <=> ADP + protein N-phospho-L-histidine
Comment(s)
  • This entry has been included to accommodate those protein-histidine kinases for which the phosphorylation site has not been established (i.e. either the pros- or tele-nitrogen of histidine).
  • A number of histones can act as acceptor.
Cross-references
PROSITEPDOC50109
BRENDA2.7.13.3
EC2PDB2.7.13.3
ExplorEnz2.7.13.3
PRIAM enzyme-specific profiles2.7.13.3
KEGG Ligand Database for Enzyme Nomenclature2.7.13.3
IUBMB Enzyme Nomenclature2.7.13.3
IntEnz2.7.13.3
MEDLINEFind literature relating to 2.7.13.3
MetaCyc2.7.13.3
UniProtKB/Swiss-Prot
Q04943, AFSQ2_STRCO;  Q9SXL4, AHK1_ARATH;  Q9C5U2, AHK2_ARATH;  
Q9C5U1, AHK3_ARATH;  Q9C5U0, AHK4_ARATH;  Q3S4A7, AHK5_ARATH;  
P58363, ARCB_ECO57;  P0AEC3, ARCB_ECOLI;  P44578, ARCB_HAEIN;  
P0AEC4, ARCB_SHIFL;  Q2FH24, ARLS_STAA3;  Q9KJN3, ARLS_STAA8;  
Q2YY04, ARLS_STAAB;  Q5HG05, ARLS_STAAC;  Q7A2R7, ARLS_STAAM;  
Q7A5N3, ARLS_STAAN;  Q6GGZ4, ARLS_STAAR;  Q6G9E7, ARLS_STAAS;  
Q7A0W5, ARLS_STAAW;  Q5HPC4, ARLS_STAEQ;  Q8CSL7, ARLS_STAES;  
Q4L6C5, ARLS_STAHJ;  Q49XM6, ARLS_STAS1;  Q9HUI3, ARUS_PSEAE;  
Q06067, ATOS_ECOLI;  P30847, BAES_ECOLI;  P0AEC7, BARA_ECO57;  
P0AEC6, BARA_ECOL6;  P0AEC5, BARA_ECOLI;  P59342, BARA_SHIFL;  
P30844, BASS_ECOLI;  P36557, BASS_SALTY;  Q9K620, BCES_BACHD;  
O35044, BCES_BACSU;  Q9RZA4, BPHY_DEIRA;  Q9HWR3, BPHY_PSEAE;  
P26762, BVGS_BORBR;  P40330, BVGS_BORPA;  P16575, BVGS_BORPE;  
P29072, CHEA_BACSU;  Q44737, CHEA_BORBU;  P07363, CHEA_ECOLI;  
P21813, CHEA_ENTAK;  B0R4J9, CHEA_HALS3;  Q92DW2, CHEA_LISIN;  
Q48768, CHEA_LISMO;  Q52880, CHEA_RHIME;  Q53135, CHEA_RHOSH;  
P09384, CHEA_SALTY;  Q56310, CHEA_THEMA;  P96123, CHEA_TREPA;  
Q5AHA0, CHK1_CANAL;  Q07737, CHVG_AGRFC;  P72292, CHVG_RHIME;  
P0A4I5, CIAH_STRPN;  P0A4I6, CIAH_STRR6;  P52687, CITA_KLEPN;  
Q9RC53, CITS_BACHD;  O34427, CITS_BACSU;  O22267, CKI1_ARATH;  
Q99027, COMP_BACSU;  Q02541, COPS_PSEUB;  P0AE84, CPXA_ECO57;  
P0AE83, CPXA_ECOL6;  P0AE82, CPXA_ECOLI;  A7N6S2, CQSS_VIBCB;  
Q9KM66, CQSS_VIBCH;  P08401, CREC_ECOLI;  Q82EB2, CSEC_STRAW;  
Q9ZEP3, CSEC_STRCO;  F4HVG8, CSK_ARATH;  O32193, CSSS_BACSU;  
Q8XBY4, CUSS_ECO57;  Q8FK37, CUSS_ECOL6;  P77485, CUSS_ECOLI;  
P0A4I7, CUTS_STRCO;  P0A4I8, CUTS_STRLI;  Q44007, CZCS_CUPMC;  
Q9HU20, DCTB_PSEAE;  P10047, DCTB_RHILE;  P13633, DCTB_RHIME;  
Q9K997, DCTS_BACHD;  P96601, DCTS_BACSU;  P37739, DCTS_RHOCA;  
P0AEC9, DCUS_ECO57;  P59340, DCUS_ECOL6;  P0AEC8, DCUS_ECOLI;  
P59341, DCUS_SHIFL;  Q03069, DEGM_BACB2;  P13799, DEGS_BACSU;  
P54663, DEGS_BREBE;  O34757, DESK_BACSU;  P9WGK2, DEVS_MYCTO;  
P9WGK3, DEVS_MYCTU;  Q54U87, DHKA_DICDI;  Q54YH4, DHKB_DICDI;  
Q95PI2, DHKC_DICDI;  Q54SP4, DHKD_DICDI;  Q55E44, DHKE_DICDI;  
Q551X9, DHKF_DICDI;  Q54Q69, DHKG_DICDI;  Q54W36, DHKH_DICDI;  
Q86AT9, DHKI_DICDI;  Q54YZ9, DHKJ_DICDI;  Q86CZ2, DHKK_DICDI;  
Q54RP6, DHKL_DICDI;  Q54SK5, DHKM_DICDI;  Q03228, DIVJ_CAUCR;  
Q9RQQ9, DIVL_CAUCR;  Q8E3C7, DLTS_STRA3;  Q8DXQ8, DLTS_STRA5;  
P77510, DPIB_ECOLI;  P20169, DSPA_SYNY3;  P0AEJ4, ENVZ_ECOLI;  
P41406, ENVZ_SALTI;  P08982, ENVZ_SALTY;  P0AEJ5, ENVZ_SHIFL;  
Q38846, ERS1_ARATH;  A2XL32, ERS1_ORYSI;  Q53RH0, ERS1_ORYSJ;  
B8AY75, ERS2_ORYSI;  Q0DKM0, ERS2_ORYSJ;  P49333, ETR1_ARATH;  
O49230, ETR1_BRAOL;  O82436, ETR1_CUCMN;  Q9SSY6, ETR1_CUCSA;  
O81122, ETR1_MALDO;  Q9ZWL6, ETR1_PASED;  Q9XH58, ETR1_PELHO;  
Q9M7M1, ETR1_PRUPE;  Q41342, ETR1_SOLLC;  O48929, ETR1_TOBAC;  
Q8H1X1, ETR2_ORYSI;  Q7XX84, ETR2_ORYSJ;  Q9XH57, ETR2_PELHO;  
O49187, ETR2_SOLLC;  Q6T5K2, ETR3_ORYSI;  Q0DWC7, ETR3_ORYSJ;  
Q6T5K3, ETR4_ORYSI;  Q7F239, ETR4_ORYSJ;  P58402, EVGS_ECO57;  
P30855, EVGS_ECOLI;  E5KK10, FILI_METH6;  P26489, FIXL_AZOC5;  
P23222, FIXL_BRADU;  P10955, FIXL_RHIME;  P18769, FRZE_MYXXA;  
P48027, GACS_PSESY;  A7HD43, GCHK_ANADF;  P40758, GLNK_BACSU;  
P52101, GLRK_ECOLI;  A7WZC5, GRAS_STAA1;  A6TZD7, GRAS_STAA2;  
Q2FIX9, GRAS_STAA3;  Q2G0D9, GRAS_STAA8;  A5IQL3, GRAS_STAA9;  
Q2YSS1, GRAS_STAAB;  Q5HI08, GRAS_STAAC;  A6QEW9, GRAS_STAAE;  
Q99VW1, GRAS_STAAM;  Q7A6Z3, GRAS_STAAN;  Q6GJ10, GRAS_STAAR;  
Q6GBH0, GRAS_STAAS;  A8Z182, GRAS_STAAT;  Q8NXR5, GRAS_STAAW;  
Q5HR80, GRAS_STAEQ;  Q8CTL4, GRAS_STAES;  Q4L482, GRAS_STAHJ;  
Q49VK4, GRAS_STAS1;  Q44930, GTCS_ANEMI;  Q9AWA5, GWD1_SOLTU;  
Q7D9K1, HK12_MYCTO;  O07778, HK1_MYCTU;  O07777, HK2_MYCTU;  
A7X5Y6, HSSS_STAA1;  A6U489, HSSS_STAA2;  Q2FED4, HSSS_STAA3;  
Q2FVQ8, HSSS_STAA8;  A5IVE3, HSSS_STAA9;  Q2YZ23, HSSS_STAAB;  
Q5HDJ3, HSSS_STAAC;  A6QJK4, HSSS_STAAE;  Q99RR5, HSSS_STAAM;  
Q7A3X0, HSSS_STAAN;  Q6GE72, HSSS_STAAR;  Q6G6V8, HSSS_STAAS;  
A8Z553, HSSS_STAAT;  Q8NV46, HSSS_STAAW;  Q5HLN1, HSSS_STAEQ;  
Q8CRA8, HSSS_STAES;  Q4L8M0, HSSS_STAHJ;  Q49ZT9, HSSS_STAS1;  
I1WSZ3, IRLS_BURP2;  P0DMK6, IRLS_BURPS;  P94608, KDPD_CLOAB;  
P21865, KDPD_ECOLI;  P9WGL2, KDPD_MYCTO;  P9WGL3, KDPD_MYCTU;  
O34971, KDPD_RATRA;  P16497, KINA_BACSU;  Q08430, KINB_BACSU;  
O34206, KINB_PSEAI;  P39764, KINC_BACSU;  O31671, KIND_BACSU;  
O31661, KINE_BACSU;  O32198, LIAS_BACSU;  B2SB67, LOVHK_BRUA1;  
Q2YKK7, LOVHK_BRUA2;  Q577Y7, LOVHK_BRUAB;  A9MBM8, LOVHK_BRUC2;  
Q8YC53, LOVHK_BRUME;  A5VUS1, LOVHK_BRUO2;  A9WYQ7, LOVHK_BRUSI;  
Q8FW73, LOVHK_BRUSU;  A6X554, LOVHK_OCHA4;  Q48IV1, LOVHK_PSE14;  
Q881J7, LOVHK_PSESM;  Q4ZSY3, LOVHK_PSEU2;  Q1M667, LOVHK_RHIL3;  
A7MRY4, LUXN_VIBCB;  P0C5S6, LUXN_VIBHA;  Q9KLK7, LUXQ_VIBCH;  
P54302, LUXQ_VIBHA;  Q87GU5, LUXQ_VIBPA;  Q8D5Z6, LUXQ_VIBVU;  
Q7MD16, LUXQ_VIBVY;  Q2NCA3, LVHK1_ERYLH;  Q2NB77, LVHK2_ERYLH;  
Q81JL2, LYTS_BACAN;  Q814J0, LYTS_BACCR;  P94513, LYTS_BACSU;  
Q82Z75, LYTS_ENTFA;  Q8EQQ2, LYTS_OCEIH;  Q2FK10, LYTS_STAA3;  
Q53705, LYTS_STAA8;  Q2YV68, LYTS_STAAB;  Q5HJB6, LYTS_STAAC;  
P60612, LYTS_STAAM;  P60613, LYTS_STAAN;  Q6GK52, LYTS_STAAR;  
Q6GCL2, LYTS_STAAS;  P60614, LYTS_STAAW;  Q5HLG3, LYTS_STAEQ;  
Q8CR79, LYTS_STAES;  Q4L8V3, LYTS_STAHJ;  Q4A009, LYTS_STAS1;  
Q8E7H4, LYTS_STRA3;  Q8E218, LYTS_STRA5;  Q8DVB6, LYTS_STRMU;  
Q9P7Q7, MAK1_SCHPO;  O14002, MAK2_SCHPO;  O74539, MAK3_SCHPO;  
O05250, MALK_BACSU;  Q1M799, MCTS_RHIL3;  A0QBR0, MPRB_MYCA1;  
Q7U0X3, MPRB_MYCBO;  A1KHB8, MPRB_MYCBP;  Q9Z5G7, MPRB_MYCLE;  
Q742C0, MPRB_MYCPA;  A0R3I7, MPRB_MYCS2;  A3Q5L8, MPRB_MYCSJ;  
A1UL69, MPRB_MYCSK;  Q1B3X9, MPRB_MYCSS;  A5U124, MPRB_MYCTA;  
P9WGL0, MPRB_MYCTO;  P9WGL1, MPRB_MYCTU;  A0PWB3, MPRB_MYCUA;  
A1TEL6, MPRB_MYCVP;  Q8THF6, MSMS_METAC;  P59963, MTRB_MYCBO;  
Q9CCJ1, MTRB_MYCLE;  Q93CB7, MTRB_MYCPA;  A0QTK3, MTRB_MYCS2;  
P9WGK8, MTRB_MYCTO;  P9WGK9, MTRB_MYCTU;  P27896, NARQ_ECOLI;  
P44604, NARQ_HAEIN;  O53857, NARS_MYCTU;  P0AFA3, NARX_ECO57;  
P0AFA2, NARX_ECOLI;  P0AFA4, NARX_SHIFL;  P70954, NATK_BACSU;  
Q3T0Q4, NDKB_BOVIN;  Q50KA8, NDKB_CANLF;  P22392, NDKB_HUMAN;  
Q01768, NDKB_MOUSE;  Q2EN76, NDKB_PIG;  Q5RFH3, NDKB_PONAB;  
P19804, NDKB_RAT;  P30663, NIFL_AZOVI;  Q5A599, NIK1_CANAL;  
P42707, NISK_LACLL;  P15939, NODV_BRADU;  A7X624, NREB_STAA1;  
A6U4C1, NREB_STAA2;  Q2FEA5, NREB_STAA3;  Q2FVM6, NREB_STAA8;  
A5IVH3, NREB_STAA9;  Q2YZ41, NREB_STAAB;  Q5HDG4, NREB_STAAC;  
A6QJN2, NREB_STAAE;  Q931F6, NREB_STAAM;  Q99RN7, NREB_STAAN;  
Q6GE41, NREB_STAAR;  Q6G6S9, NREB_STAAS;  A8Z581, NREB_STAAT;  
Q7A028, NREB_STAAW;  Q7WZY5, NREB_STACT;  Q5HLK5, NREB_STAEQ;  
Q8CR97, NREB_STAES;  Q4L8Q7, NREB_STAHJ;  P45670, NTRB_AZOBR;  
P10578, NTRB_BRASR;  P0AFB6, NTRB_ECO57;  P0AFB5, NTRB_ECOLI;  
P06218, NTRB_KLEOX;  P28788, NTRB_PROHU;  P41503, NTRB_RHILP;  
Q52977, NTRB_RHIME;  P09431, NTRB_RHOCB;  P0A2E0, NTRB_SALTI;  
P0A2D9, NTRB_SALTY;  P0AFB7, NTRB_SHIFL;  P19906, NTRB_VIBAL;  
Q1RJB3, NTRYL_RICBR;  Q92H24, NTRYL_RICCN;  Q4UMD4, NTRYL_RICFE;  
Q9ZCU7, NTRYL_RICPR;  Q68WC5, NTRYL_RICTY;  P45675, NTRY_AZOBR;  
Q04850, NTRY_AZOC5;  A2YFR6, OHK1_ORYSI;  A3BE68, OHK1_ORYSJ;  
A2YA15, OHK2_ORYSI;  Q5SML4, OHK2_ORYSJ;  A2WYI4, OHK3_ORYSI;  
A1A696, OHK3_ORYSJ;  A1A698, OHK4_ORYSJ;  A1A697, OHK5_ORYSJ;  
A1A699, OHK6_ORYSJ;  Q47457, PCOS_ECOLX;  B2S758, PDHS_BRUA1;  
Q2YRB4, PDHS_BRUA2;  Q57BR6, PDHS_BRUAB;  A9M715, PDHS_BRUC2;  
Q8YIM6, PDHS_BRUME;  A5VRX4, PDHS_BRUO2;  B0CI82, PDHS_BRUSI;  
Q8FZ86, PDHS_BRUSU;  A6X5X4, PDHS_OCHA4;  P9WGL4, PDTAS_MYCTO;  
P9WGL5, PDTAS_MYCTU;  Q04804, PFES_PSEAE;  P37433, PGTB_SALTY;  
Q8X739, PHOQ_ECO57;  Q8FIB8, PHOQ_ECOL6;  P23837, PHOQ_ECOLI;  
Q57QC4, PHOQ_SALCH;  Q5PMJ0, PHOQ_SALPA;  D0ZV89, PHOQ_SALT1;  
Q8Z7H3, PHOQ_SALTI;  E1WFA0, PHOQ_SALTS;  F5ZP94, PHOQ_SALTU;  
P0DM80, PHOQ_SALTY;  Q83RR1, PHOQ_SHIFL;  P23545, PHOR_BACSU;  
P08400, PHOR_ECOLI;  P71380, PHOR_HAEIN;  P45608, PHOR_KLEPN;  
P23621, PHOR_PSEAE;  P45609, PHOR_SHIDY;  Q55168, PHY1_SYNY3;  
Q9LCC2, PHYA_NOSS1;  Q9R6X3, PHYB_NOSS1;  P33639, PILS_PSEAE;  
P37894, PLEC_CAUCR;  Q70FG9, PMRB_PECSS;  P0A5Z9, PRRB_MYCBO;  
O33071, PRRB_MYCLE;  P9WGK6, PRRB_MYCTO;  P9WGK7, PRRB_MYCTU;  
Q8X524, QSEC_ECO57;  P40719, QSEC_ECOLI;  P45336, QSEC_HAEIN;  
Q8Z3P2, QSEC_SALTI;  Q8ZLZ9, QSEC_SALTY;  Q8XA47, QSEE_ECO57;  
P0DMC5, RCSC_ECOLI;  P0DMC6, RCSC_ECOLX;  Q56128, RCSC_SALTI;  
P58662, RCSC_SALTY;  Q3J6C1, REGB_RHOS4;  P0C0Z0, REGB_RHOSH;  
P35164, RESE_BACSU;  P0C0F7, RPFC_XANC8;  P0C0F6, RPFC_XANCP;  
Q08408, RPRX_BACFR;  Q8GP19, RSSA_SERMA;  P18392, RSTB_ECOLI;  
Q2FIT5, SAES_STAA3;  Q2G2U1, SAES_STAA8;  Q2YSM6, SAES_STAAB;  
Q5HHW5, SAES_STAAC;  Q840P7, SAES_STAAE;  Q99VR8, SAES_STAAM;  
Q7A6V4, SAES_STAAN;  Q6GIT7, SAES_STAAR;  Q6GBC5, SAES_STAAS;  
Q7A1J2, SAES_STAAW;  Q5HR29, SAES_STAEQ;  Q8CTI3, SAES_STAES;  
Q8YR50, SASA_NOSS1;  Q7BWI3, SASA_PROMA;  Q7V6P7, SASA_PROMM;  
Q7V113, SASA_PROMP;  Q06904, SASA_SYNE7;  Q7U871, SASA_SYNPX;  
Q55630, SASA_SYNY3;  Q8DMT2, SASA_THEEB;  P0A601, SENX3_MYCBO;  
A0QR01, SENX3_MYCS2;  P9WGK4, SENX3_MYCTO;  P9WGK5, SENX3_MYCTU;  
P54883, SEX3_MYCLE;  Q9ZHD4, SILS_SALTM;  Q5A872, SLN1_CANAL;  
P39928, SLN1_YEAST;  P33113, SPAK_BACIU;  P39664, SPHS_SYNE7;  
Q2FY80, SRRB_STAA8;  Q5HFT1, SRRB_STAAC;  Q99TZ9, SRRB_STAAM;  
Q7A5H7, SRRB_STAAN;  Q6GGK7, SRRB_STAAR;  Q6G973, SRRB_STAAS;  
Q9L523, SRRB_STAAU;  Q8NWF3, SRRB_STAAW;  O69729, TCRY_MYCTU;  
Q9P896, TCSA_EMENI;  Q9P4U6, TCSB_EMENI;  O87939, TDIS_THAAR;  
Q8KIY1, TMOS_PSEME;  A5W4E3, TODS_PSEP1;  E0X9C7, TODS_PSEPT;  
P58356, TORS_ECO57;  P39453, TORS_ECOLI;  Q8ZPP6, TTRS_SALTY;  
P09835, UHPB_ECOLI;  P27668, UHPB_SALTY;  Q47745, VANS_ENTFA;  
Q06240, VANS_ENTFC;  P07167, VIRAL_RHIRD;  P07168, VIRAW_RHIRD;  
P18540, VIRA_AGRFC;  P10799, VIRA_AGRT9;  Q9KWK8, VRAS_STAA1;  
Q5HEN9, VRAS_STAAC;  Q7A2Q0, VRAS_STAAM;  Q99SZ7, VRAS_STAAN;  
Q6GFH2, VRAS_STAAR;  Q6G849, VRAS_STAAS;  Q7A0H9, VRAS_STAAW;  
Q5HN49, VRAS_STAEQ;  Q8CRV2, VRAS_STAES;  Q4L7J6, VRAS_STAHJ;  
Q49YT0, VRAS_STAS1;  A7WWQ7, WALK_STAA1;  A6TXG9, WALK_STAA2;  
Q2FKN7, WALK_STAA3;  Q2G2U4, WALK_STAA8;  A5INR0, WALK_STAA9;  
Q2YUQ2, WALK_STAAB;  Q5HJX6, WALK_STAAC;  A6QD58, WALK_STAAE;  
Q7A305, WALK_STAAM;  Q7A8E0, WALK_STAAN;  Q6GKS6, WALK_STAAR;  
Q6GD71, WALK_STAAS;  A8YYU2, WALK_STAAT;  Q9RDT3, WALK_STAAU;  
Q7A215, WALK_STAAW;  Q5HK19, WALK_STAEQ;  Q8CU87, WALK_STAES;  
Q4LAJ8, WALK_STAHJ;  Q4A159, WALK_STAS1;  A5A2P0, WALK_STASR;  
Q52969, Y1002_RHIME;  Q2YV55, Y162_STAAB;  Q8CU03, Y166_STAES;  
Q2G1E0, Y185_STAA8;  Q6GCQ2, Y199_STAAS;  Q8NYJ8, Y199_STAAW;  
Q5HJF6, Y202_STAAC;  Q6GK92, Y215_STAAR;  Q7A7X8, Y216_STAAN;  
Q2FK46, Y218_STAA3;  Q99WZ9, Y224_STAAM;  Q5HKE1, Y2405_STAEQ;  
Q02482, Y3689_SHEFN;  O31433, YBDK_BACSU;  P42245, YCBM_BACSU;  
P51392, YCF26_PORPU;  Q1XD95, YCF26_PYRYE;  P94414, YCLK_BACSU;  
P96685, YDFH_BACSU;  P76339, YEDV_ECOLI;  P0AD15, YEHU_ECOL6;  
P0AD14, YEHU_ECOLI;  P0AD16, YEHU_SHIFL;  O31516, YESM_BACSU;  
P94438, YFIJ_BACSU;  O07527, YHCY_BACSU;  O34638, YKOH_BACSU;  
P0AA94, YPDA_ECO57;  P0AA93, YPDA_ECOLI;  P54444, YRKQ_BACSU;  
O06979, YVCQ_BACSU;  Q795K2, YVFT_BACSU;  O34989, YVRG_BACSU;  
P42422, YXDK_BACSU;  P55183, YXJM_BACSU;  Q45614, YYCG_BACSU;  
Q8X614, ZRAS_ECO57;  P14377, ZRAS_ECOLI;  Q9APE0, ZRAS_KLEOX;  
Q8Z332, ZRAS_SALTI;  P37461, ZRAS_SALTY;  

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