ENZYME entry: EC 2.7.4.24

Accepted Name
Diphosphoinositol-pentakisphosphate kinase.
Alternative Name(s)
Diphosphoinositol pentakisphosphate kinase.
PP-InsP(5) kinase.
PP-IP(5) kinase.
Reaction catalysed
  • ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate <=> ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
  • ATP + 1D-myo-inositol hexakisphosphate <=> ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
Comment(s)
  • This enzyme is activated by osmotic shock.
  • Ins(1,3,4,5,6)P(5), 1D-myo-inositol diphosphate tetrakisphosphate and 1D-myo-inositol bisdiphosphate triphosphate are not substrates.
  • Formerly EC 2.7.1.155.
Cross-references
BRENDA2.7.4.24
EC2PDB2.7.4.24
ExplorEnz2.7.4.24
PRIAM enzyme-specific profiles2.7.4.24
KEGG Ligand Database for Enzyme Nomenclature2.7.4.24
IUBMB Enzyme Nomenclature2.7.4.24
IntEnz2.7.4.24
MEDLINEFind literature relating to 2.7.4.24
MetaCyc2.7.4.24
UniProtKB/Swiss-Prot
A7Z050, VIP1_BOVIN;  P91309, VIP1_CAEEL;  Q9VR59, VIP1_DROME;  
Q6PFW1, VIP1_HUMAN;  A2ARP1, VIP1_MOUSE;  Q5RDF1, VIP1_PONAB;  
P0C644, VIP1_RAT;  O74429, VIP1_SCHPO;  Q06685, VIP1_YEAST;  
O43314, VIP2_HUMAN;  Q6ZQB6, VIP2_MOUSE;  Q5REW0, VIP2_PONAB;  
Q5XHF8, VIP2_XENLA;  

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