ENZYME entry: EC 2.7.7.19

Accepted Name
Polynucleotide adenylyltransferase.
Alternative Name(s)
NTP polymerase.
Poly(A) polymerase.
RNA adenylating enzyme.
Reaction catalysed
ATP + RNA(n) <=> diphosphate + RNA(n+1)
Comment(s)
  • Also acts slowly with CTP.
  • Catalyzes template-independent extension of the 3'-end of a DNA strand by one nucleotide at a time.
  • Cannot initiate a chain de novo.
  • The primer, depending on the source of the enzyme, may be an RNA or DNA fragment or oligo(A) bearing a 3'-OH terminal group.
  • See also EC 2.7.7.6.
Cross-references
BRENDA2.7.7.19
EC2PDB2.7.7.19
ExplorEnz2.7.7.19
PRIAM enzyme-specific profiles2.7.7.19
KEGG Ligand Database for Enzyme Nomenclature2.7.7.19
IUBMB Enzyme Nomenclature2.7.7.19
IntEnz2.7.7.19
MEDLINEFind literature relating to 2.7.7.19
MetaCyc2.7.7.19
UniProtKB/Swiss-Prot
O74326, CID11_SCHPO;  O74518, CID12_SCHPO;  Q9UT49, CID13_SCHPO;  
Q9UTN3, CID14_SCHPO;  Q9VD44, GLD2A_DROME;  Q641A1, GLD2A_XENLA;  
Q9VYS4, GLD2B_DROME;  Q6DFA8, GLD2B_XENLA;  Q2HJ44, GLD2_BOVIN;  
O17087, GLD2_CAEEL;  Q503I9, GLD2_DANRE;  Q6PIY7, GLD2_HUMAN;  
Q91YI6, GLD2_MOUSE;  Q5U315, GLD2_RAT;  Q0VFA3, GLD2_XENTR;  
G5EFL0, GLD4_CAEEL;  Q65159, PAP1_ASFB7;  P0C9D5, PAP1_ASFK5;  
P0C9D2, PAP1_ASFM2;  P0C9D3, PAP1_ASFP4;  P0C9D4, PAP1_ASFWA;  
Q8V2W4, PAP1_CAMPM;  Q8QQ67, PAP1_CAMPS;  Q6VZL8, PAP1_CNPV;  
Q070J7, PAP1_CPRVZ;  Q8QMZ9, PAP1_CWPXB;  Q80E12, PAP1_CWPXG;  
Q08FW1, PAP1_DPV83;  Q08FE1, PAP1_DPV84;  Q8JLG4, PAP1_ECTVM;  
Q9J5B8, PAP1_FOWPN;  Q0GP30, PAP1_HSPV;  Q91MX5, PAP1_LSDV;  
Q98199, PAP1_MCV1;  Q5UQS6, PAP1_MIMIV;  Q9Q8R9, PAP1_MYXVL;  
Q2F8F7, PAP1_ORFN2;  Q6RZP5, PAP1_RABPU;  Q9Q944, PAP1_RFVKA;  
Q8V3R4, PAP1_SWPV1;  O57184, PAP1_VACCA;  P21079, PAP1_VACCC;  
Q9JFD9, PAP1_VACCT;  P23371, PAP1_VACCW;  P33809, PAP1_VAR67;  
Q9DHT0, PAP1_YLDV;  Q6TUY0, PAP1_YMTV5;  Q9UW26, PAPA_CANAL;  
Q9NVV4, PAPD1_HUMAN;  Q9D0D3, PAPD1_MOUSE;  Q8NDF8, PAPD5_HUMAN;  
Q68ED3, PAPD5_MOUSE;  Q5XG87, PAPD7_HUMAN;  Q6PB75, PAPD7_MOUSE;  
P51004, PAPO1_XENLA;  P51005, PAPO2_XENLA;  P51006, PAPO3_XENLA;  
P25500, PAPOA_BOVIN;  P51003, PAPOA_HUMAN;  Q61183, PAPOA_MOUSE;  
Q9NRJ5, PAPOB_HUMAN;  Q9WVP6, PAPOB_MOUSE;  Q9BWT3, PAPOG_HUMAN;  
Q6PCL9, PAPOG_MOUSE;  Q9LMT2, PAPS1_ARATH;  O82312, PAPS2_ARATH;  
Q56XM9, PAPS3_ARATH;  Q8VYW1, PAPS4_ARATH;  O42617, PAP_CANAL;  
Q54J73, PAP_DICDI;  Q51D88, PAP_ENTHI;  Q10295, PAP_SCHPO;  
P29468, PAP_YEAST;  P0ABF3, PCNB_ECO57;  P0ABF2, PCNB_ECOL6;  
P0ABF1, PCNB_ECOLI;  P44439, PCNB_HAEIN;  Q8Z9C3, PCNB_SALTI;  
Q8ZRQ8, PCNB_SALTY;  D2HS90, STPAP_AILME;  Q1JPD6, STPAP_BOVIN;  
Q4KMD7, STPAP_DANRE;  Q9H6E5, STPAP_HUMAN;  Q8R3F9, STPAP_MOUSE;  
Q3MHT4, STPAP_RAT;  A9JTS5, STPAP_XENTR;  

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