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ENZYME entry: EC 2.7.7.4

Accepted Name
Sulfate adenylyltransferase.
Alternative Name(s)
ATP-sulfurylase.
Sulfate adenylate transferase.
Sulfurylase.
Reaction catalysed
ATP + sulfate <=> diphosphate + adenylyl sulfate
Comment(s)
  • The human phosphoadenosine-phosphosulfate synthase (PAPS) system is a bifunctional enzyme: ATP sulfurylase, which catalyzes the formation of adenosine 5'-phosphosulfate (APS) from ATP and inorganic sulfate and the second step is catalyzed by the APS kinase portion of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase, which involves the formation of PAPS from enzyme bound APS and ATP.
  • This is in contrast to what is found in bacteria, yeasts, fungi and plants, where the formation of PAPS is carried out by two individual polypeptides, EC 2.7.7.4 and EC 2.7.1.25.
Cross-references
BRENDA2.7.7.4
EC2PDB2.7.7.4
ExplorEnz2.7.7.4
PRIAM enzyme-specific profiles2.7.7.4
KEGG Ligand Database for Enzyme Nomenclature2.7.7.4
IUBMB Enzyme Nomenclature2.7.7.4
IntEnz2.7.7.4
MEDLINEFind literature relating to 2.7.7.4
MetaCyc2.7.7.4
UniProtKB/Swiss-Prot
Q9LIK9, APS1_ARATH;  Q43870, APS2_ARATH;  O23324, APS3_ARATH;  
Q9S7D8, APS4_ARATH;  Q0A977, CYSD1_ALKEH;  Q1QWX0, CYSD1_CHRSD;  
A1U3Y0, CYSD1_MARHV;  A8FXJ5, CYSD1_SHESH;  Q0A653, CYSD2_ALKEH;  
Q1QUF8, CYSD2_CHRSD;  A1U490, CYSD2_MARHV;  A8FXM2, CYSD2_SHESH;  
Q6FDA0, CYSD_ACIAD;  B0VSD7, CYSD_ACIBS;  B0V9N5, CYSD_ACIBY;  
A0KP36, CYSD_AERHH;  A4SRG9, CYSD_AERS4;  Q7D0L8, CYSD_AGRFC;  
B9JB96, CYSD_AGRRK;  B9JT86, CYSD_AGRVS;  B2URN8, CYSD_AKKM8;  
B6ELP2, CYSD_ALISL;  A8EWR5, CYSD_ARCB4;  C1DQ71, CYSD_AZOVD;  
Q5LES4, CYSD_BACFN;  Q64VR0, CYSD_BACFR;  Q8AAQ0, CYSD_BACTN;  
A6KXG8, CYSD_BACV8;  Q1LTP5, CYSD_BAUCH;  A5E8X6, CYSD_BRASB;  
A4YYA7, CYSD_BRASO;  Q2YP46, CYSD_BRUA2;  Q57FI5, CYSD_BRUAB;  
A9M7D7, CYSD_BRUC2;  C0RGP5, CYSD_BRUMB;  Q8YEX2, CYSD_BRUME;  
A5VNC5, CYSD_BRUO2;  B0CJ51, CYSD_BRUSI;  Q8G2W6, CYSD_BRUSU;  
B8D9K2, CYSD_BUCA5;  P57499, CYSD_BUCAI;  B8D7V4, CYSD_BUCAT;  
Q39EM7, CYSD_BURL3;  Q9A881, CYSD_CAUCR;  B0T3J3, CYSD_CAUSK;  
Q11K42, CYSD_CHESB;  A4SDU0, CYSD_CHLPM;  Q7NVN6, CYSD_CHRVO;  
A8ANW6, CYSD_CITK8;  Q483A0, CYSD_COLP3;  A7MJ68, CYSD_CROS8;  
A7ZQJ6, CYSD_ECO24;  B7UHH1, CYSD_ECO27;  B7MKM6, CYSD_ECO45;  
B7LEH0, CYSD_ECO55;  Q8X7X4, CYSD_ECO57;  B5Z3B4, CYSD_ECO5E;  
B7NT96, CYSD_ECO7I;  B7MZ53, CYSD_ECO81;  B7LXG4, CYSD_ECO8A;  
C4ZZQ6, CYSD_ECOBW;  B1XCS8, CYSD_ECODH;  A8A3N1, CYSD_ECOHS;  
A1AEU6, CYSD_ECOK1;  Q0TEA6, CYSD_ECOL5;  Q8FEJ0, CYSD_ECOL6;  
B1IUS7, CYSD_ECOLC;  P21156, CYSD_ECOLI;  B7N6Y2, CYSD_ECOLU;  
B6I6E2, CYSD_ECOSE;  B1LQ73, CYSD_ECOSM;  Q1R7T9, CYSD_ECOUT;  
A4WDV7, CYSD_ENT38;  B2VG02, CYSD_ERWT9;  B7LWK3, CYSD_ESCF3;  
B5EF56, CYSD_GEOBB;  B9M197, CYSD_GEODF;  B3E8X9, CYSD_GEOLS;  
Q39RP7, CYSD_GEOMG;  C6E751, CYSD_GEOSM;  A5G8G3, CYSD_GEOUR;  
Q2SBG0, CYSD_HAHCH;  A1WZK4, CYSD_HALHL;  Q0C438, CYSD_HYPNA;  
B5XV29, CYSD_KLEP3;  A6TD44, CYSD_KLEP7;  A0L6E2, CYSD_MAGMM;  
Q0ALV0, CYSD_MARMM;  A6VXC5, CYSD_MARMS;  B7L0Y0, CYSD_METC4;  
Q604B7, CYSD_METCA;  A9W4X2, CYSD_METEP;  B8IRX8, CYSD_METNO;  
B1Z7C1, CYSD_METPB;  B1LSA1, CYSD_METRJ;  B0U8Y5, CYSD_METS4;  
P65671, CYSD_MYCBO;  A1KI72, CYSD_MYCBP;  A4T8Q2, CYSD_MYCGI;  
A3Q3I2, CYSD_MYCSJ;  A1UK27, CYSD_MYCSK;  Q1B510, CYSD_MYCSS;  
A5U1Y3, CYSD_MYCTA;  P9WIK0, CYSD_MYCTO;  P9WIK1, CYSD_MYCTU;  
A1TDE9, CYSD_MYCVP;  Q1D9W6, CYSD_MYXXD;  Q5YUA1, CYSD_NOCFA;  
A6WVC7, CYSD_OCHA4;  A6LA51, CYSD_PARD8;  Q6D1A5, CYSD_PECAS;  
C6DDH0, CYSD_PECCP;  Q3A3P5, CYSD_PELCD;  Q7N8L1, CYSD_PHOLL;  
Q6LM68, CYSD_PHOPR;  B4F231, CYSD_PROMH;  Q48ED3, CYSD_PSE14;  
Q15VB5, CYSD_PSEA6;  A6VBB6, CYSD_PSEA7;  B7UZY2, CYSD_PSEA8;  
Q02GZ8, CYSD_PSEAB;  O50273, CYSD_PSEAE;  Q1I585, CYSD_PSEE4;  
Q4KI67, CYSD_PSEF5;  C3KDP1, CYSD_PSEFS;  Q3ILR0, CYSD_PSEHT;  
A4XQP2, CYSD_PSEMY;  A5W8T2, CYSD_PSEP1;  Q3KHY6, CYSD_PSEPF;  
B0KGN7, CYSD_PSEPG;  Q88NA9, CYSD_PSEPK;  B1J166, CYSD_PSEPW;  
Q87WW0, CYSD_PSESM;  Q4ZNW4, CYSD_PSEU2;  A4VIE6, CYSD_PSEU5;  
A1ST25, CYSD_PSYIN;  B3PTD3, CYSD_RHIE6;  Q2KB48, CYSD_RHIEC;  
Q1MJV3, CYSD_RHIL3;  Q985Q5, CYSD_RHILO;  B5ZUF6, CYSD_RHILW;  
P56892, CYSD_RHIME;  O33580, CYSD_RHITR;  Q07UU1, CYSD_RHOP5;  
Q21D94, CYSD_RHOPB;  Q2RS06, CYSD_RHORT;  Q21IS4, CYSD_SACD2;  
B5F416, CYSD_SALA4;  A9MF23, CYSD_SALAR;  Q57KI9, CYSD_SALCH;  
B5FTT0, CYSD_SALDC;  B5QW23, CYSD_SALEP;  B5RDQ8, CYSD_SALG2;  
B4TFX2, CYSD_SALHS;  B4T462, CYSD_SALNS;  Q5PEH1, CYSD_SALPA;  
A9N2D9, CYSD_SALPB;  B5BEY9, CYSD_SALPK;  B4TTW6, CYSD_SALSV;  
P65673, CYSD_SALTI;  P65672, CYSD_SALTY;  A8G9Y4, CYSD_SERP5;  
A1S9N7, CYSD_SHEAM;  B8EE60, CYSD_SHEB2;  A3D822, CYSD_SHEB5;  
A6WJU3, CYSD_SHEB8;  A9L389, CYSD_SHEB9;  Q12QM9, CYSD_SHEDO;  
Q07Y91, CYSD_SHEFN;  B0TTD5, CYSD_SHEHH;  A3QCU1, CYSD_SHELP;  
Q8EB09, CYSD_SHEON;  A8H0A3, CYSD_SHEPA;  A4Y9X3, CYSD_SHEPC;  
B8CSV0, CYSD_SHEPW;  A0KTI2, CYSD_SHESA;  Q0HFM4, CYSD_SHESM;  
Q0HYA6, CYSD_SHESR;  A1RGF7, CYSD_SHESW;  B1KMH3, CYSD_SHEWM;  
B2TZH9, CYSD_SHIB3;  Q31XB4, CYSD_SHIBS;  Q32CH8, CYSD_SHIDS;  
Q0T1I3, CYSD_SHIF8;  P59740, CYSD_SHIFL;  Q3YYB0, CYSD_SHISS;  
Q2NVM9, CYSD_SODGM;  Q30U93, CYSD_SULDN;  A6QB13, CYSD_SULNB;  
A5F579, CYSD_VIBC3;  A7MWG4, CYSD_VIBCB;  Q9KP19, CYSD_VIBCH;  
C3LRM2, CYSD_VIBCM;  Q5E831, CYSD_VIBF1;  B5FGJ8, CYSD_VIBFM;  
Q87SY0, CYSD_VIBPA;  B7VKY3, CYSD_VIBTL;  Q8DE72, CYSD_VIBVU;  
Q7MPF3, CYSD_VIBVY;  Q8PHD0, CYSD_XANAC;  Q3BPY6, CYSD_XANC5;  
Q4UY06, CYSD_XANC8;  B0RPG8, CYSD_XANCB;  Q8P610, CYSD_XANCP;  
Q2P0H4, CYSD_XANOM;  B2SI03, CYSD_XANOP;  Q9PD79, CYSD_XYLFA;  
Q87DG8, CYSD_XYLFT;  A1JJS9, CYSD_YERE8;  A7FLY3, CYSD_YERP3;  
Q1C483, CYSD_YERPA;  B2K572, CYSD_YERPB;  Q8ZBP1, CYSD_YERPE;  
A9R1C3, CYSD_YERPG;  Q1CLS1, CYSD_YERPN;  A4TPZ2, CYSD_YERPP;  
Q66EC8, CYSD_YERPS;  B1JJG3, CYSD_YERPY;  Q5NRM5, CYSD_ZYMMO;  
P9WNM4, CYSNC_MYCTO;  P9WNM5, CYSNC_MYCTU;  O50274, CYSNC_PSEAE;  
Q7UMW2, CYSNC_RHOBA;  Q9PD78, CYSNC_XYLFA;  Q87DG7, CYSNC_XYLFT;  
A0KP35, CYSN_AERHH;  A4SRG8, CYSN_AERS4;  Q8UH69, CYSN_AGRFC;  
B9JB95, CYSN_AGRRK;  B6ELP3, CYSN_ALISL;  B4RTW4, CYSN_ALTMD;  
A8EWR6, CYSN_ARCB4;  Q5LES3, CYSN_BACFN;  Q64VQ9, CYSN_BACFR;  
Q8AAP9, CYSN_BACTN;  B8D9K1, CYSN_BUCA5;  P57498, CYSN_BUCAI;  
B8D7V3, CYSN_BUCAT;  B3PII1, CYSN_CELJU;  Q1QUF9, CYSN_CHRSD;  
Q7NVN5, CYSN_CHRVO;  A8ANW5, CYSN_CITK8;  Q482Z9, CYSN_COLP3;  
A7MJ69, CYSN_CROS8;  A7ZQJ5, CYSN_ECO24;  B7UHH0, CYSN_ECO27;  
B7MKM5, CYSN_ECO45;  B7LEG9, CYSN_ECO55;  Q8X7X7, CYSN_ECO57;  
B5Z3B3, CYSN_ECO5E;  B7NT95, CYSN_ECO7I;  B7MZ52, CYSN_ECO81;  
B7LXG3, CYSN_ECO8A;  C4ZZQ5, CYSN_ECOBW;  B1XCS7, CYSN_ECODH;  
A8A3N0, CYSN_ECOHS;  A1AEU5, CYSN_ECOK1;  Q0TEA7, CYSN_ECOL5;  
Q8FEJ1, CYSN_ECOL6;  B1IUS8, CYSN_ECOLC;  P23845, CYSN_ECOLI;  
B7N6Y1, CYSN_ECOLU;  B6I6E1, CYSN_ECOSE;  B1LQ72, CYSN_ECOSM;  
Q1R7U0, CYSN_ECOUT;  B2VG01, CYSN_ERWT9;  B7LWK4, CYSN_ESCF3;  
Q14HG2, CYSN_FRAT1;  A0Q6F0, CYSN_FRATN;  Q5NG10, CYSN_FRATT;  
A4IXZ5, CYSN_FRATW;  C1D890, CYSN_LARHH;  B7L0X9, CYSN_METC4;  
A9W4X1, CYSN_METEP;  B1Z7C0, CYSN_METPB;  Q7N8L0, CYSN_PHOLL;  
Q6LM69, CYSN_PHOPR;  Q15VB8, CYSN_PSEA6;  A1ST27, CYSN_PSYIN;  
P56893, CYSN_RHIME;  O33581, CYSN_RHITR;  Q21IS6, CYSN_SACD2;  
B5F415, CYSN_SALA4;  A9MF24, CYSN_SALAR;  Q57KJ0, CYSN_SALCH;  
B5FTS9, CYSN_SALDC;  B5QW22, CYSN_SALEP;  B5RDQ7, CYSN_SALG2;  
B4TFX1, CYSN_SALHS;  B4T461, CYSN_SALNS;  Q5PEH2, CYSN_SALPA;  
A9N2D8, CYSN_SALPB;  C0PXB1, CYSN_SALPC;  B5BEY8, CYSN_SALPK;  
B4TTW5, CYSN_SALSV;  Q8Z470, CYSN_SALTI;  Q8ZMF5, CYSN_SALTY;  
Q8EB10, CYSN_SHEON;  B1KMH4, CYSN_SHEWM;  B2TZI0, CYSN_SHIB3;  
Q31XB3, CYSN_SHIBS;  Q32CH9, CYSN_SHIDS;  Q0T1I2, CYSN_SHIF8;  
Q83JX8, CYSN_SHIFL;  Q3YYB1, CYSN_SHISS;  Q2NVM8, CYSN_SODGM;  
A6QB12, CYSN_SULNB;  C5BSJ5, CYSN_TERTT;  C4LAG3, CYSN_TOLAT;  
A5F578, CYSN_VIBC3;  A7MWE9, CYSN_VIBCB;  Q9KP20, CYSN_VIBCH;  
C3LRM1, CYSN_VIBCM;  Q5E830, CYSN_VIBF1;  B5FGJ9, CYSN_VIBFM;  
Q87SX9, CYSN_VIBPA;  B7VKY2, CYSN_VIBTL;  Q8DE73, CYSN_VIBVU;  
Q7MPF2, CYSN_VIBVY;  A1JJT0, CYSN_YERE8;  A7FLY2, CYSN_YERP3;  
Q8ZBP2, CYSN_YERPE;  Q66EC7, CYSN_YERPS;  Q74ZF6, MET3_ASHGO;  
A1CJC1, MET3_ASPCL;  Q4WWN8, MET3_ASPFU;  Q8NJN1, MET3_ASPNG;  
Q8NK83, MET3_ASPOR;  P56862, MET3_ASPTE;  Q0CC19, MET3_ASPTN;  
Q9Y872, MET3_CANAL;  Q6FXQ8, MET3_CANGA;  Q2H454, MET3_CHAGB;  
Q1EAF9, MET3_COCIM;  P0CN05, MET3_CRYNB;  Q8TG24, MET3_CRYNH;  
P0CN04, MET3_CRYNJ;  Q6BSU5, MET3_DEBHA;  Q12555, MET3_EMENI;  
Q4I1N3, MET3_GIBZE;  Q6CNU6, MET3_KLULA;  Q8J0I4, MET3_MUCCL;  
A1D858, MET3_NEOFI;  Q7SE75, MET3_NEUCR;  Q12650, MET3_PENCH;  
Q0V6P9, MET3_PHANO;  P78937, MET3_SCHPO;  Q4P460, MET3_USTMA;  
Q6CFD2, MET3_YARLI;  P08536, MET3_YEAST;  Q9X5U0, MMCV_STRLA;  
P28603, NODP_AZOBR;  P13441, NODP_RHIME;  P72338, NODP_RHIS3;  
O07308, NODP_RHISB;  P52995, NODP_RHITR;  P28604, NODQ_AZOBR;  
P13442, NODQ_RHIME;  P72339, NODQ_RHIS3;  O07309, NODQ_RHISB;  
P52978, NODQ_RHITR;  O54820, PAPS1_CAVPO;  O43252, PAPS1_HUMAN;  
Q60967, PAPS1_MOUSE;  O95340, PAPS2_HUMAN;  O88428, PAPS2_MOUSE;  
Q27128, PAPSS_URECA;  O34764, SAT1_BACSU;  O06736, SAT2_BACSU;  
A9ENT2, SATC1_SORC5;  A9G7W0, SATC2_SORC5;  O67174, SATC_AQUAE;  
B0BZ94, SAT_ACAM1;  Q9YCR4, SAT_AERPE;  Q0VRM0, SAT_ALCBS;  
O66036, SAT_ALLVD;  Q3MAI6, SAT_ANAVT;  O28606, SAT_ARCFU;  
C3P517, SAT_BACAA;  C3L9N5, SAT_BACAC;  A0RBN3, SAT_BACAH;  
Q81T48, SAT_BACAN;  B7JGQ4, SAT_BACC0;  Q73B75, SAT_BACC1;  
B7INB5, SAT_BACC2;  C1EMR9, SAT_BACC3;  B7HHH7, SAT_BACC4;  
B7HKE6, SAT_BACC7;  A7GMW1, SAT_BACCN;  B9IV12, SAT_BACCQ;  
Q81FZ0, SAT_BACCR;  Q63DV8, SAT_BACCZ;  Q6HLD3, SAT_BACHK;  
Q65JT9, SAT_BACLD;  A8FD24, SAT_BACP2;  Q5WKF4, SAT_BACSK;  
A7Z4H9, SAT_BACVZ;  A9VLJ0, SAT_BACWK;  Q3A8R0, SAT_CARHZ;  
A0RYU6, SAT_CENSY;  A9WFJ2, SAT_CHLAA;  Q3AQ83, SAT_CHLCH;  
B3ELG8, SAT_CHLPB;  B9LKB9, SAT_CHLSY;  Q8KE30, SAT_CHLTE;  
B7JVS6, SAT_CYAP8;  C1CVW9, SAT_DEIDV;  Q1IYH9, SAT_DEIGD;  
P56864, SAT_DEIRA;  B8FB52, SAT_DESAA;  B1I3M7, SAT_DESAP;  
B8J4A8, SAT_DESDA;  A4J272, SAT_DESRM;  O76156, SAT_ENTHI;  
Q5L2Y0, SAT_GEOKA;  C5D5A6, SAT_GEOSW;  A4IKB5, SAT_GEOTN;  
Q7NLN7, SAT_GLOVI;  B8D0S5, SAT_HALOH;  A2BMW0, SAT_HYPBU;  
A8AB48, SAT_IGNH4;  Q88X61, SAT_LACPL;  B1HXC8, SAT_LYSSC;  
B0JW81, SAT_MICAN;  A9A541, SAT_NITMS;  B2J5M3, SAT_NOSP7;  
Q8EQN5, SAT_OCEIH;  B4SAM9, SAT_PELPB;  A5D5R7, SAT_PELTS;  
C0QSU0, SAT_PERMH;  A9BFU2, SAT_PETMO;  P84547, SAT_POPEU;  
Q4FST7, SAT_PSYA2;  Q1QAY1, SAT_PSYCK;  A5WEH0, SAT_PSYWF;  
P56863, SAT_PYRAB;  Q60FC6, SAT_PYRYE;  Q54506, SAT_RIFPS;  
Q1AXE5, SAT_RUBXD;  A1AVC7, SAT_RUTMC;  B9DLL5, SAT_STACT;  
Q5HL01, SAT_STAEQ;  Q8CR03, SAT_STAES;  Q4L9E7, SAT_STAHJ;  
A3DLD9, SAT_STAMF;  Q49UM4, SAT_STAS1;  Q67QB5, SAT_SYMTH;  
Q31RJ2, SAT_SYNE7;  A0LH38, SAT_SYNFM;  Q2JU97, SAT_SYNJA;  
B1XLP7, SAT_SYNP2;  Q5N2R3, SAT_SYNP6;  P74241, SAT_SYNY3;  
B6YUW9, SAT_THEON;  Q3SEZ6, SAT_THIDA;  Q111K4, SAT_TRIEI;  
A5CXS6, SAT_VESOH;  

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