ENZYME entry: EC 2.7.7.49

Accepted Name
RNA-directed DNA polymerase.
Alternative Name(s)
DNA nucleotidyltransferase (RNA-directed).
Reverse transcriptase.
Revertase.
Reaction catalysed
Deoxynucleoside triphosphate + DNA(n) <=> diphosphate + DNA(n+1)
Comment(s)
  • Catalyzes RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time.
  • Cannot initiate a chain de novo.
  • Requires a RNA or DNA primer.
  • DNA can also serve as template.
  • See also EC 2.7.7.7.
Cross-references
PROSITEPDOC50878
BRENDA2.7.7.49
EC2PDB2.7.7.49
ExplorEnz2.7.7.49
PRIAM enzyme-specific profiles2.7.7.49
KEGG Ligand Database for Enzyme Nomenclature2.7.7.49
IUBMB Enzyme Nomenclature2.7.7.49
IntEnz2.7.7.49
MEDLINEFind literature relating to 2.7.7.49
MetaCyc2.7.7.49
UniProtKB/Swiss-Prot
Q64898, DPOL_ASHV;  P03162, DPOL_DHBV1;  P0C691, DPOL_DHBV3;  
Q66403, DPOL_DHBVQ;  P03161, DPOL_GSHV;  P03158, DPOL_HBVA2;  
P03159, DPOL_HBVA3;  P17100, DPOL_HBVA4;  Q02314, DPOL_HBVA5;  
Q91C36, DPOL_HBVA6;  O91533, DPOL_HBVA7;  Q4R1S7, DPOL_HBVA8;  
Q4R1R9, DPOL_HBVA9;  P17394, DPOL_HBVB1;  P17393, DPOL_HBVB2;  
Q9QAB8, DPOL_HBVB3;  P17395, DPOL_HBVB4;  Q9PX62, DPOL_HBVB5;  
Q67925, DPOL_HBVB6;  Q9QBF1, DPOL_HBVB7;  P0C676, DPOL_HBVB8;  
Q9E6S5, DPOL_HBVC0;  P0C688, DPOL_HBVC1;  Q9YZR5, DPOL_HBVC2;  
P12933, DPOL_HBVC3;  P31870, DPOL_HBVC4;  P03157, DPOL_HBVC5;  
Q913A7, DPOL_HBVC7;  Q81165, DPOL_HBVC8;  P0C690, DPOL_HBVC9;  
Q69028, DPOL_HBVCJ;  P12900, DPOL_HBVCP;  P03155, DPOL_HBVD1;  
P24024, DPOL_HBVD2;  P03156, DPOL_HBVD3;  Q9QMI1, DPOL_HBVD4;  
P0C679, DPOL_HBVD5;  Q67878, DPOL_HBVD6;  O56655, DPOL_HBVD7;  
Q69602, DPOL_HBVE1;  Q80IU7, DPOL_HBVE2;  Q9QAW8, DPOL_HBVE3;  
Q80IU4, DPOL_HBVE4;  Q05486, DPOL_HBVF1;  Q8JMY4, DPOL_HBVF2;  
Q99HS4, DPOL_HBVF3;  Q99HR5, DPOL_HBVF4;  Q69605, DPOL_HBVF6;  
Q8QZQ2, DPOL_HBVG2;  Q9IBI4, DPOL_HBVG3;  P87744, DPOL_HBVGB;  
Q9YPV8, DPOL_HBVGO;  Q8JMY7, DPOL_HBVH1;  Q8JN08, DPOL_HBVH2;  
Q8JMZ7, DPOL_HBVH3;  Q9J5S2, DPOL_HBVOR;  P13846, DPOL_HHBV;  
P17192, DPOL_HPBDB;  P30028, DPOL_HPBDC;  P17193, DPOL_HPBDW;  
P03160, DPOL_WHV1;  P06275, DPOL_WHV2;  P12899, DPOL_WHV3;  
P12898, DPOL_WHV4;  P17396, DPOL_WHV5;  P11292, DPOL_WHV6;  
O71304, DPOL_WMHBV;  P08548, LIN1_NYCCO;  O00370, LORF2_HUMAN;  
P11369, LORF2_MOUSE;  P0A3U0, LTRA_LACLC;  P0A3U1, LTRA_LACLM;  
Q03277, PO11_BRACO;  Q03269, PO11_NASVI;  Q03276, PO11_POPJA;  
Q03270, PO12_NASVI;  Q03271, PO13_NASVI;  Q03272, PO14_NASVI;  
Q03279, PO21_BRACO;  Q03278, PO21_NASVI;  Q03273, PO21_POPJA;  
Q03274, PO22_POPJA;  Q05118, PO23_POPJA;  Q03275, PO24_POPJA;  
P10266, POK10_HUMAN;  P63135, POK12_HUMAN;  P63136, POK17_HUMAN;  
Q9UQG0, POK20_HUMAN;  Q9BXR3, POK2_HUMAN;  Q9WJR5, POK3_HUMAN;  
P63128, POK4_HUMAN;  P63132, POK5_HUMAN;  P63133, POK6_HUMAN;  
Q9QC07, POK7_HUMAN;  P10399, POL1_CHICK;  P10400, POL1_MOUSE;  
P20825, POL2_DROME;  P04323, POL3_DROME;  P10394, POL4_DROME;  
Q8I7P9, POL5_DROME;  Q91DM0, POLG_PVCV1;  Q6XKE6, POLG_PVCV2;  
P16423, POLR_DROME;  P10978, POLX_TOBAC;  P10401, POLY_DROME;  
Q7SQ98, POL_ALV;  P03360, POL_AVIRE;  P10272, POL_BAEVM;  
P19560, POL_BIV29;  P25059, POL_BLVAU;  P03361, POL_BLVJ;  
P33459, POL_CAEVC;  P03555, POL_CAMVC;  P03556, POL_CAMVD;  
Q02964, POL_CAMVE;  Q00962, POL_CAMVN;  P03554, POL_CAMVS;  
P05400, POL_CERV;  P19199, POL_COYMV;  Q89703, POL_CSVMV;  
Q7TD08, POL_CYLCV;  P11204, POL_EIAV9;  P32542, POL_EIAVC;  
P03371, POL_EIAVY;  P31792, POL_FENV1;  O93209, POL_FFV;  
P16088, POL_FIVPE;  P19028, POL_FIVSD;  P31822, POL_FIVT2;  
P10273, POL_FLV;  P09523, POL_FMVD;  P14350, POL_FOAMV;  
P21414, POL_GALV;  P03362, POL_HTL1A;  P14078, POL_HTL1C;  
P0C211, POL_HTL1L;  Q0R5R2, POL_HTL32;  Q4U0X6, POL_HTL3P;  
P03363, POL_HTLV2;  O93215, POL_HV190;  O12158, POL_HV192;  
O89290, POL_HV193;  Q9QBY3, POL_HV196;  Q9QBZ9, POL_HV197;  
O41798, POL_HV19N;  P03369, POL_HV1A2;  Q77373, POL_HV1AN;  
P03366, POL_HV1B1;  P04587, POL_HV1B5;  Q73368, POL_HV1B9;  
P03367, POL_HV1BR;  P04589, POL_HV1EL;  Q75002, POL_HV1ET;  
P04585, POL_HV1H2;  P20875, POL_HV1JR;  P0C6F2, POL_HV1LW;  
Q9QBZ1, POL_HV1M2;  P04588, POL_HV1MA;  P05961, POL_HV1MN;  
Q9QBZ5, POL_HV1MP;  Q79666, POL_HV1MV;  P12497, POL_HV1N5;  
P18802, POL_HV1ND;  P20892, POL_HV1OY;  P05959, POL_HV1RH;  
Q9WC54, POL_HV1S2;  Q9WC63, POL_HV1S9;  O89940, POL_HV1SE;  
P24740, POL_HV1U4;  Q9Q720, POL_HV1V9;  Q9QSR3, POL_HV1VI;  
P35963, POL_HV1Y2;  Q9IDV9, POL_HV1YB;  O91080, POL_HV1YF;  
P12499, POL_HV1Z2;  P18096, POL_HV2BE;  P24107, POL_HV2CA;  
P17757, POL_HV2D1;  P15833, POL_HV2D2;  Q89928, POL_HV2EH;  
P18042, POL_HV2G1;  Q74120, POL_HV2KR;  P05962, POL_HV2NZ;  
P04584, POL_HV2RO;  P12451, POL_HV2SB;  P20876, POL_HV2ST;  
Q76634, POL_HV2UC;  P04026, POL_IPHA;  P11368, POL_IPMA;  
P12894, POL_IPMAI;  Q82851, POL_JEMBR;  P31623, POL_JSRV;  
Q9TTC1, POL_KORV;  P03356, POL_MLVAV;  P26810, POL_MLVF5;  
P26809, POL_MLVFF;  P26808, POL_MLVFP;  P03355, POL_MLVMS;  
P11227, POL_MLVRD;  P31795, POL_MLVRK;  P03365, POL_MMTVB;  
P11283, POL_MMTVC;  P07572, POL_MPMV;  P16901, POL_OMVVS;  
P03358, POL_RSFFV;  P03354, POL_RSVP;  Q04095, POL_RSVSA;  
O92956, POL_RSVSB;  P27502, POL_RTBVP;  P23074, POL_SFV1;  
P27401, POL_SFV3L;  Q87040, POL_SFVCP;  P17283, POL_SIVCZ;  
Q1A249, POL_SIVEK;  Q02836, POL_SIVG1;  P22382, POL_SIVGB;  
P05896, POL_SIVM1;  Q1A267, POL_SIVMB;  P05897, POL_SIVMK;  
P12502, POL_SIVS4;  P19505, POL_SIVSP;  Q8AII1, POL_SIVTN;  
P27973, POL_SIVV1;  P27980, POL_SIVVG;  P05895, POL_SIVVT;  
P03364, POL_SMRVH;  P15629, POL_SOCMV;  P04025, POL_SRV1;  
P51517, POL_SRV2;  P03370, POL_VILV;  P23426, POL_VILV1;  
P23427, POL_VILV2;  P35956, POL_VILVK;  O92815, POL_WDSV;  
P03359, POL_WMSV;  Q2F7J3, POL_XMRV3;  Q2F7J0, POL_XMRV4;  
A1Z651, POL_XMRV6;  P19593, RDPO_ACUOB;  P23072, RT16_MYXXA;  
P23071, RT65_MYXXA;  P21325, RT67_ECOLX;  P23070, RT86_ECOLX;  
Q95SX7, RTBS_DROME;  P21329, RTJK_DROFU;  P21328, RTJK_DROME;  
P15594, RTP2_TRYBG;  Q9NBX4, RTXE_DROME;  Q94818, TE80_TETTH;  
Q94819, TE95_TETTH;  Q9SPU7, TERT_ARATH;  Q27ID4, TERT_BOVIN;  
Q6A548, TERT_CANFA;  O00939, TERT_EUPAE;  O14746, TERT_HUMAN;  
O70372, TERT_MOUSE;  Q8LKW0, TERT_ORYSJ;  O76332, TERT_OXYTR;  
Q673L6, TERT_RAT;  O13339, TERT_SCHPO;  O77448, TERT_TETTH;  
Q06163, TERT_YEAST;  Q07163, TY1AB_YEASX;  O13527, YA11B_YEAST;  
Q12490, YB11B_YEAST;  Q12193, YB12B_YEAST;  Q12491, YB21B_YEAST;  
P25384, YC21B_YEAST;  Q03855, YD11B_YEAST;  Q99231, YD12B_YEAST;  
Q07793, YD13B_YEAST;  P0C2I2, YD14B_YEAST;  P0C2I3, YD15B_YEAST;  
Q12472, YD21B_YEAST;  Q03494, YD22B_YEAST;  Q07791, YD23B_YEAST;  
Q03612, YE11B_YEAST;  Q03619, YE12B_YEAST;  P0CX63, YF21B_YEAST;  
Q12141, YG11B_YEAST;  Q12269, YG12B_YEAST;  Q12316, YG13B_YEAST;  
Q12337, YG21B_YEAST;  P0CX64, YG22B_YEAST;  Q99315, YG31B_YEAST;  
O13535, YH11B_YEAST;  P0C2J7, YH41B_YEAST;  Q7LHG5, YI31B_YEAST;  
P47098, YJ11B_YEAST;  P47100, YJ12B_YEAST;  P47024, YJ41B_YEAST;  
Q12088, YL11B_YEAST;  P0C2I5, YL12B_YEAST;  P0C2I6, YL13B_YEAST;  
P0C2I7, YL14B_YEAST;  P0C2J3, YL21B_YEAST;  P0C2J5, YL22B_YEAST;  
Q04711, YM11B_YEAST;  Q03434, YM12B_YEAST;  Q04214, YM13B_YEAST;  
Q04670, YM14B_YEAST;  Q12112, YN11B_YEAST;  Q99337, YN12B_YEAST;  
Q12273, YO11B_YEAST;  Q92393, YO12B_YEAST;  Q12113, YO21B_YEAST;  
Q12501, YO22B_YEAST;  Q12414, YP11B_YEAST;  P0C2I9, YP12B_YEAST;  
P0C2J0, YP13B_YEAST;  P0C2J1, YP14B_YEAST;  

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