ENZYME entry: EC 2.7.7.60

Accepted Name
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase.
Alternative Name(s)
4-diphosphocytidyl-2-C-methyl-D-erythritol synthase.
MCT.
MEP cytidylyltransferase.
Reaction catalysed
CTP + 2-C-methyl-D-erythritol 4-phosphate <=> diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
Cofactor(s)
Mn(2+) or Mg(2+).
Comment(s)
  • ATP or UTP can replace CTP, but both are less effective.
  • GTP and TTP are not substrates.
  • Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis.
Cross-references
BRENDA2.7.7.60
EC2PDB2.7.7.60
ExplorEnz2.7.7.60
PRIAM enzyme-specific profiles2.7.7.60
KEGG Ligand Database for Enzyme Nomenclature2.7.7.60
IUBMB Enzyme Nomenclature2.7.7.60
IntEnz2.7.7.60
MEDLINEFind literature relating to 2.7.7.60
MetaCyc2.7.7.60
UniProtKB/Swiss-Prot
Q92F40, ISPD1_LISIN;  Q724H7, ISPD1_LISMF;  Q8YAB5, ISPD1_LISMO;  
Q2YV76, ISPD1_STAAB;  Q5HJC5, ISPD1_STAAC;  P65176, ISPD1_STAAM;  
P65177, ISPD1_STAAN;  Q6GK63, ISPD1_STAAR;  Q6GCM3, ISPD1_STAAS;  
Q8NYI0, ISPD1_STAAW;  Q87LQ2, ISPD1_VIBPA;  Q92CV0, ISPD2_LISIN;  
Q720Y7, ISPD2_LISMF;  Q8Y832, ISPD2_LISMO;  Q2YV73, ISPD2_STAAB;  
Q5HJC1, ISPD2_STAAC;  Q99WW8, ISPD2_STAAM;  Q7A7V0, ISPD2_STAAN;  
Q6GK57, ISPD2_STAAR;  Q6GCL7, ISPD2_STAAS;  Q7A1W0, ISPD2_STAAW;  
Q87Q30, ISPD2_VIBPA;  B9JF01, ISPDF_AGRRK;  Q8UFF4, ISPDF_AGRT5;  
B9JW91, ISPDF_AGRVS;  Q2IQG8, ISPDF_ANADE;  A7HDA2, ISPDF_ANADF;  
A8ER37, ISPDF_ARCB4;  A8IBL6, ISPDF_AZOC5;  A1USA2, ISPDF_BARBK;  
Q6G3Z8, ISPDF_BARHE;  Q6G164, ISPDF_BARQU;  A9IS87, ISPDF_BART1;  
Q89LQ8, ISPDF_BRADU;  A5EIY9, ISPDF_BRASB;  A4YUQ7, ISPDF_BRASO;  
Q2YPW1, ISPDF_BRUA2;  Q57D18, ISPDF_BRUAB;  Q8YHD8, ISPDF_BRUME;  
A5VQP4, ISPDF_BRUO2;  Q8G0H4, ISPDF_BRUSU;  A7ZCQ2, ISPDF_CAMC1;  
A7GZI1, ISPDF_CAMC5;  A0RN28, ISPDF_CAMFF;  A7I1V2, ISPDF_CAMHC;  
A8FNR8, ISPDF_CAMJ8;  A7H5V8, ISPDF_CAMJD;  Q9PM68, ISPDF_CAMJE;  
A1W1K9, ISPDF_CAMJJ;  Q5HSI4, ISPDF_CAMJR;  B9KEX3, ISPDF_CAMLR;  
B8GW85, ISPDF_CAUCN;  Q9A7I5, ISPDF_CAUCR;  Q11HV9, ISPDF_CHESB;  
A5CTY4, ISPDF_CLAM3;  Q310X3, ISPDF_DESAG;  B1I0S9, ISPDF_DESAP;  
C4XSW4, ISPDF_DESMR;  Q6ARN9, ISPDF_DESPS;  Q72C30, ISPDF_DESVH;  
A1VDX6, ISPDF_DESVV;  A8LKV5, ISPDF_DINSH;  Q2NAE1, ISPDF_ERYLH;  
Q5FQD6, ISPDF_GLUOX;  Q0BTD5, ISPDF_GRABC;  Q17WU1, ISPDF_HELAH;  
Q7VFU3, ISPDF_HELHP;  B6JL03, ISPDF_HELP2;  B5Z6H4, ISPDF_HELPG;  
Q1CU78, ISPDF_HELPH;  Q9ZM19, ISPDF_HELPJ;  B2USR1, ISPDF_HELPS;  
O25664, ISPDF_HELPY;  Q0C0N0, ISPDF_HYPNA;  Q28Q60, ISPDF_JANSC;  
Q1MR76, ISPDF_LAWIP;  Q6ADI0, ISPDF_LEIXX;  Q2W4Q8, ISPDF_MAGSA;  
Q0APQ6, ISPDF_MARMM;  Q1QM99, ISPDF_NITHX;  A6Q2K0, ISPDF_NITSB;  
Q3SSN8, ISPDF_NITWN;  Q2G708, ISPDF_NOVAD;  A6X0N1, ISPDF_OCHA4;  
A1B890, ISPDF_PARDP;  A7HXV6, ISPDF_PARL1;  Q4FM31, ISPDF_PELUB;  
B3PYS4, ISPDF_RHIE6;  Q2K8V5, ISPDF_RHIEC;  Q1MH21, ISPDF_RHIL3;  
Q98MX9, ISPDF_RHILO;  B5ZNB6, ISPDF_RHILW;  Q92Q90, ISPDF_RHIME;  
Q08113, ISPDF_RHOCB;  Q21YT7, ISPDF_RHOFT;  Q2IW23, ISPDF_RHOP2;  
Q07MZ2, ISPDF_RHOP5;  Q6N6M5, ISPDF_RHOPA;  Q214R1, ISPDF_RHOPB;  
Q137C3, ISPDF_RHOPS;  B3QIL5, ISPDF_RHOPT;  Q2RTS1, ISPDF_RHORT;  
Q5LRN5, ISPDF_RUEPO;  Q1GGW9, ISPDF_RUEST;  A6U8F8, ISPDF_SINMW;  
Q1GTN0, ISPDF_SPHAL;  A5V2U9, ISPDF_SPHWW;  Q30QG7, ISPDF_SULDN;  
A6Q7M3, ISPDF_SULNB;  O83525, ISPDF_TREPA;  Q83NK3, ISPDF_TROW8;  
Q83MX3, ISPDF_TROWT;  Q73G24, ISPDF_WOLPM;  Q7MQW9, ISPDF_WOLSU;  
Q5GSM7, ISPDF_WOLTR;  Q9RNZ1, ISPDF_ZYMMO;  B0C9F6, ISPD_ACAM1;  
Q6FAU1, ISPD_ACIAD;  B2I2A2, ISPD_ACIBC;  B0VQH8, ISPD_ACIBS;  
A3M5X8, ISPD_ACIBT;  B0V5E6, ISPD_ACIBY;  C1F763, ISPD_ACIC5;  
B7J4C0, ISPD_ACIF2;  B5EMB5, ISPD_ACIF5;  A3N0G2, ISPD_ACTP2;  
B3H1E1, ISPD_ACTP7;  B0BP82, ISPD_ACTPJ;  A6VQY1, ISPD_ACTSZ;  
A0KGH5, ISPD_AERHH;  B6EKL6, ISPD_ALISL;  A6TWL0, ISPD_ALKMQ;  
A8MLB1, ISPD_ALKOO;  B4RZG5, ISPD_ALTMD;  Q3MAF5, ISPD_ANAVT;  
O67343, ISPD_AQUAE;  P69834, ISPD_ARATH;  Q5NYJ9, ISPD_AROAE;  
B6YQA2, ISPD_AZOPC;  A1K644, ISPD_AZOSB;  A7Z0L2, ISPD_BACA2;  
A0R8F7, ISPD_BACAH;  Q81VV5, ISPD_BACAN;  Q73FC1, ISPD_BACC1;  
A7GJZ7, ISPD_BACCN;  Q81J63, ISPD_BACCR;  Q63HB4, ISPD_BACCZ;  
Q5L917, ISPD_BACFN;  Q64P77, ISPD_BACFR;  Q9KGF8, ISPD_BACHD;  
Q6HPT2, ISPD_BACHK;  Q65PD2, ISPD_BACLD;  A8F958, ISPD_BACP2;  
Q5WLT7, ISPD_BACSK;  Q06755, ISPD_BACSU;  Q8A0U8, ISPD_BACTN;  
A6KXL8, ISPD_BACV8;  A9VN98, ISPD_BACWK;  Q1LTP8, ISPD_BAUCH;  
B3DTQ9, ISPD_BIFLD;  Q8G7E2, ISPD_BIFLO;  B7GMX1, ISPD_BIFLS;  
Q494E8, ISPD_BLOPB;  Q7WCW3, ISPD_BORBR;  Q7W5C9, ISPD_BORPA;  
A9II44, ISPD_BORPD;  Q7VZN2, ISPD_BORPE;  P57495, ISPD_BUCAI;  
Q8K9D6, ISPD_BUCAP;  Q1BHA5, ISPD_BURCA;  A0K867, ISPD_BURCH;  
B4EC23, ISPD_BURCJ;  Q0BED6, ISPD_BURCM;  Q39FB8, ISPD_BURL3;  
A9AIT5, ISPD_BURM1;  A3MKM4, ISPD_BURM7;  A2SBD6, ISPD_BURM9;  
Q62JI5, ISPD_BURMA;  A1V500, ISPD_BURMS;  A3NWE0, ISPD_BURP0;  
Q3JR99, ISPD_BURP1;  A3NAL9, ISPD_BURP6;  B2JGK2, ISPD_BURP8;  
B2T3X2, ISPD_BURPP;  Q63T70, ISPD_BURPS;  Q2SWT6, ISPD_BURTA;  
A4JF20, ISPD_BURVG;  Q13Z31, ISPD_BURXL;  B9MJW2, ISPD_CALBD;  
Q8R7S6, ISPD_CALS4;  A4XLJ3, ISPD_CALS8;  Q3A9N7, ISPD_CARHZ;  
Q5L6V2, ISPD_CHLAB;  Q3AS33, ISPD_CHLCH;  Q824I4, ISPD_CHLCV;  
Q253C1, ISPD_CHLFF;  Q9PJT1, ISPD_CHLMU;  B3QP85, ISPD_CHLP8;  
B3EQ34, ISPD_CHLPB;  Q9Z7X5, ISPD_CHLPN;  B0B835, ISPD_CHLT2;  
B3QXK8, ISPD_CHLT3;  Q3KLN6, ISPD_CHLTA;  B0BCA0, ISPD_CHLTB;  
Q8KCU3, ISPD_CHLTE;  O84468, ISPD_CHLTR;  Q1QU73, ISPD_CHRSD;  
Q7NYL6, ISPD_CHRVO;  A8ANW1, ISPD_CITK8;  Q97EC9, ISPD_CLOAB;  
A7FZ94, ISPD_CLOB1;  C3KVS6, ISPD_CLOB6;  A6LPN9, ISPD_CLOB8;  
B2TIF4, ISPD_CLOBB;  A5I7N1, ISPD_CLOBH;  C1FMX6, ISPD_CLOBJ;  
B1IGH9, ISPD_CLOBK;  A7GJ99, ISPD_CLOBL;  B1KTA8, ISPD_CLOBM;  
B9DY87, ISPD_CLOK1;  A5N4M5, ISPD_CLOK5;  A0PXS4, ISPD_CLONN;  
Q0TMM2, ISPD_CLOP1;  Q8XHQ3, ISPD_CLOPE;  A9KSU6, ISPD_CLOPH;  
Q0SQB9, ISPD_CLOPS;  Q890M1, ISPD_CLOTE;  Q487E9, ISPD_COLP3;  
Q6NFC1, ISPD_CORDI;  Q8FMI3, ISPD_COREF;  A4QH60, ISPD_CORGB;  
Q8NMB8, ISPD_CORGL;  Q4JXJ7, ISPD_CORJK;  A7MJ57, ISPD_CROS8;  
Q472F2, ISPD_CUPPJ;  B1WSY4, ISPD_CYAA5;  Q47EL2, ISPD_DECAR;  
Q3ZAD7, ISPD_DEHM1;  A5FP88, ISPD_DEHMB;  Q3ZWE1, ISPD_DEHMC;  
Q1J200, ISPD_DEIGD;  Q9RR90, ISPD_DEIRA;  A4J0Y3, ISPD_DESRM;  
B5YF77, ISPD_DICT6;  A7ZQJ1, ISPD_ECO24;  B7UHG6, ISPD_ECO27;  
B7MKM1, ISPD_ECO45;  B7LEG5, ISPD_ECO55;  Q8X7Y4, ISPD_ECO57;  
B5Z3A9, ISPD_ECO5E;  B7NT91, ISPD_ECO7I;  B7MYQ2, ISPD_ECO81;  
B7LXF9, ISPD_ECO8A;  C4ZZQ1, ISPD_ECOBW;  B1XCS3, ISPD_ECODH;  
A8A3M6, ISPD_ECOHS;  A1AEU1, ISPD_ECOK1;  Q0TEB1, ISPD_ECOL5;  
Q8FEJ5, ISPD_ECOL6;  B1IUT2, ISPD_ECOLC;  Q46893, ISPD_ECOLI;  
B7N6X7, ISPD_ECOLU;  B6I6D7, ISPD_ECOSE;  B1LQ67, ISPD_ECOSM;  
Q1R7U4, ISPD_ECOUT;  A4WDV2, ISPD_ENT38;  B7LWK8, ISPD_ESCF3;  
C4Z312, ISPD_EUBE2;  Q2J542, ISPD_FRASC;  Q8R6H2, ISPD_FUSNN;  
Q5L433, ISPD_GEOKA;  Q39ZL5, ISPD_GEOMG;  Q746Z9, ISPD_GEOSL;  
A4IJG4, ISPD_GEOTN;  A5G938, ISPD_GEOUR;  Q7NGU6, ISPD_GLOVI;  
Q7VLT5, ISPD_HAEDU;  Q4QMP4, ISPD_HAEI8;  A5UE59, ISPD_HAEIE;  
A5UHG1, ISPD_HAEIG;  O05029, ISPD_HAEIN;  Q2SKW7, ISPD_HAHCH;  
A1WWZ0, ISPD_HALHL;  Q5QUC3, ISPD_IDILO;  B5XV34, ISPD_KLEP3;  
A6TD39, ISPD_KLEP7;  Q03A83, ISPD_LACC3;  Q88W46, ISPD_LACPL;  
C1D558, ISPD_LARHH;  Q04VR0, ISPD_LEPBJ;  Q04XR1, ISPD_LEPBL;  
Q72P59, ISPD_LEPIC;  Q8F7A0, ISPD_LEPIN;  B1HNM7, ISPD_LYSSC;  
Q65Q78, ISPD_MANSM;  Q604M2, ISPD_METCA;  B0JUF7, ISPD_MICAN;  
Q2RFM0, ISPD_MOOTA;  Q7TW54, ISPD_MYCBO;  A1KPR8, ISPD_MYCBP;  
C1AI41, ISPD_MYCBT;  B8ZUA7, ISPD_MYCLB;  Q9CCW6, ISPD_MYCLE;  
B2HJ23, ISPD_MYCMM;  Q743W5, ISPD_MYCPA;  A5U8Q7, ISPD_MYCTA;  
P9WKG8, ISPD_MYCTO;  P9WKG9, ISPD_MYCTU;  A0PV29, ISPD_MYCUA;  
Q5F829, ISPD_NEIG1;  B4RL14, ISPD_NEIG2;  A9M0U7, ISPD_NEIM0;  
Q9JTM3, ISPD_NEIMA;  Q9JYM4, ISPD_NEIMB;  A1KUV0, ISPD_NEIMF;  
Q2GEM3, ISPD_NEOSM;  Q0AFW3, ISPD_NITEC;  Q82UR9, ISPD_NITEU;  
Q2Y751, ISPD_NITMU;  Q3JCS9, ISPD_NITOC;  Q5Z2R3, ISPD_NOCFA;  
B2J1D2, ISPD_NOSP7;  Q8YLX9, ISPD_NOSS1;  Q5N8G1, ISPD_ORYSJ;  
Q6MEE8, ISPD_PARUW;  P57953, ISPD_PASMU;  Q6D1B3, ISPD_PECAS;  
C6DDG2, ISPD_PECCP;  Q3A8C6, ISPD_PELCD;  Q3B3A7, ISPD_PELLD;  
B4SAG7, ISPD_PELPB;  A5D5L4, ISPD_PELTS;  Q18CD1, ISPD_PEPD6;  
A9BHR2, ISPD_PETMO;  Q7N8K7, ISPD_PHOLL;  Q6LMT3, ISPD_PHOPR;  
B2RJ15, ISPD_PORG3;  Q7MUQ9, ISPD_PORGI;  B4S8U7, ISPD_PROA2;  
Q6AAV8, ISPD_PROAC;  A3PBH7, ISPD_PROM0;  A8G3G9, ISPD_PROM2;  
A9BE76, ISPD_PROM4;  A2BVB5, ISPD_PROM5;  Q31C80, ISPD_PROM9;  
Q7VDC7, ISPD_PROMA;  Q7V647, ISPD_PROMM;  Q7V2M1, ISPD_PROMP;  
A2BPT7, ISPD_PROMS;  Q46GW4, ISPD_PROMT;  A4SF04, ISPD_PROVI;  
Q48F81, ISPD_PSE14;  Q15P31, ISPD_PSEA6;  A6V1F5, ISPD_PSEA7;  
Q02RA5, ISPD_PSEAB;  P57707, ISPD_PSEAE;  Q1I648, ISPD_PSEE4;  
Q4KHF4, ISPD_PSEF5;  C3K6H8, ISPD_PSEFS;  Q3IDQ6, ISPD_PSEHT;  
A4XWR9, ISPD_PSEMY;  A5W827, ISPD_PSEP1;  Q3KH90, ISPD_PSEPF;  
B0KSC1, ISPD_PSEPG;  Q88MF7, ISPD_PSEPK;  B1JB36, ISPD_PSEPW;  
Q886M1, ISPD_PSESM;  Q4ZWQ6, ISPD_PSEU2;  Q4FR76, ISPD_PSYA2;  
Q1Q9K8, ISPD_PSYCK;  Q8XYW3, ISPD_RALSO;  Q7UM15, ISPD_RHOBA;  
C0ZPR7, ISPD_RHOE4;  Q0S890, ISPD_RHOJR;  C1BAC2, ISPD_RHOOB;  
A3PJQ3, ISPD_RHOS1;  Q3J2K9, ISPD_RHOS4;  A4WSL5, ISPD_RHOS5;  
B9KSH8, ISPD_RHOSK;  Q165P6, ISPD_ROSDO;  Q1AU08, ISPD_RUBXD;  
A1AX25, ISPD_RUTMC;  A4F6W3, ISPD_SACEN;  B5F411, ISPD_SALA4;  
A9MF28, ISPD_SALAR;  Q57KJ4, ISPD_SALCH;  B5FTS5, ISPD_SALDC;  
B5QW18, ISPD_SALEP;  B5RDQ3, ISPD_SALG2;  B4TFW7, ISPD_SALHS;  
B4T457, ISPD_SALNS;  Q5PEG1, ISPD_SALPA;  A9N2D3, ISPD_SALPB;  
C0PXA7, ISPD_SALPC;  B5BEY4, ISPD_SALPK;  Q2S210, ISPD_SALRD;  
B4TTW1, ISPD_SALSV;  Q8Z471, ISPD_SALTI;  Q8ZMF6, ISPD_SALTY;  
A8G9Z2, ISPD_SERP5;  A1S4D9, ISPD_SHEAM;  Q12PZ2, ISPD_SHEDO;  
Q086A8, ISPD_SHEFN;  B0TK06, ISPD_SHEHH;  A3QC79, ISPD_SHELP;  
Q8EBR2, ISPD_SHEON;  A8H1S7, ISPD_SHEPA;  B8CJP8, ISPD_SHEPW;  
A8FST0, ISPD_SHESH;  B2TZI4, ISPD_SHIB3;  Q31XA9, ISPD_SHIBS;  
Q32CI3, ISPD_SHIDS;  Q0T1H8, ISPD_SHIF8;  Q7C093, ISPD_SHIFL;  
Q3YYB5, ISPD_SHISS;  Q2NVM4, ISPD_SODGM;  Q027G1, ISPD_SOLUE;  
Q2FK15, ISPD_STAA3;  Q2G1C0, ISPD_STAA8;  Q5HRJ7, ISPD_STAEQ;  
Q8CQ77, ISPD_STAES;  Q4A0A8, ISPD_STAS1;  Q3K093, ISPD_STRA1;  
Q8E4B4, ISPD_STRA3;  Q8DYQ7, ISPD_STRA5;  Q82GC8, ISPD_STRAW;  
Q9L0Q8, ISPD_STRCO;  B4SR88, ISPD_STRM5;  B2FK90, ISPD_STRMK;  
Q04K52, ISPD_STRP2;  B5E508, ISPD_STRP4;  C1C7P9, ISPD_STRP7;  
B1IC62, ISPD_STRPI;  B8ZJT5, ISPD_STRPJ;  Q97QE5, ISPD_STRPN;  
B2IQ63, ISPD_STRPS;  Q8DPI2, ISPD_STRR6;  C1CEM5, ISPD_STRZJ;  
C1CL05, ISPD_STRZP;  C1CR35, ISPD_STRZT;  Q67JP5, ISPD_SYMTH;  
Q2LUS9, ISPD_SYNAS;  Q31QF6, ISPD_SYNE7;  A0LIS2, ISPD_SYNFM;  
Q2JUE5, ISPD_SYNJA;  Q5N3T2, ISPD_SYNP6;  A5GMW9, ISPD_SYNPW;  
Q7U559, ISPD_SYNPX;  Q0I880, ISPD_SYNS3;  Q3AWK9, ISPD_SYNS9;  
Q3ALY8, ISPD_SYNSC;  P74323, ISPD_SYNY3;  B7IF61, ISPD_THEAB;  
Q8DL91, ISPD_THEEB;  Q47LV0, ISPD_THEFY;  A6LPA6, ISPD_THEM4;  
Q9X1B3, ISPD_THEMA;  B9K8U1, ISPD_THENN;  A5IMI1, ISPD_THEP1;  
B1LBT2, ISPD_THESQ;  Q72GN3, ISPD_THET2;  Q5SLX2, ISPD_THET8;  
Q3SK38, ISPD_THIDA;  C4LBQ9, ISPD_TOLAT;  Q118M1, ISPD_TRIEI;  
B1GYT4, ISPD_UNCTG;  A5CW51, ISPD_VESOH;  Q9KUJ2, ISPD_VIBCH;  
Q5E328, ISPD_VIBF1;  B5FAF7, ISPD_VIBFM;  B7VK66, ISPD_VIBTL;  
Q8DC60, ISPD_VIBVU;  Q7MHQ4, ISPD_VIBVY;  Q8D223, ISPD_WIGBR;  
Q8PLR8, ISPD_XANAC;  Q3BUS8, ISPD_XANC5;  Q4UTP4, ISPD_XANC8;  
B0RU03, ISPD_XANCB;  Q8P9Z1, ISPD_XANCP;  Q2P1L0, ISPD_XANOM;  
B2SUA8, ISPD_XANOP;  Q5GYK6, ISPD_XANOR;  B2I939, ISPD_XYLF2;  
Q9PDT6, ISPD_XYLFA;  B0U660, ISPD_XYLFM;  Q87DY4, ISPD_XYLFT;  
A7FLX8, ISPD_YERP3;  B2K577, ISPD_YERPB;  Q8ZBP6, ISPD_YERPE;  
A9R119, ISPD_YERPG;  Q1CLR6, ISPD_YERPN;  A4TPZ7, ISPD_YERPP;  
Q66EC3, ISPD_YERPS;  B1JJF8, ISPD_YERPY;  

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