ENZYME entry: EC 2.7.7.65
| Accepted Name |
|---|
| Diguanylate cyclase.
|
| Alternative Name(s) |
|---|
| DGC. |
| Reaction catalysed |
|---|
| 2 GTP <=> 2 diphosphate + cyclic di-3',5'-guanylate |
| Cofactor(s) |
|---|
| Magnesium; Manganese.
|
| Comment(s) |
|---|
- Can be activated by BeF3, a phosphoryl mimic, which results in
dimerization.
- Dimerization is required but is not sufficient for diguanylate-
cyclase activity.
- Cyclic di-3',5'-guanylate is an intracellular signaling molecule that
controls motility and adhesion in bacterial cells; it was first
identified as having a positive allosteric effect on EC 2.4.1.12.
|
| Cross-references |
|---|
| BRENDA | 2.7.7.65 |
| EC2PDB | 2.7.7.65 |
| ExplorEnz | 2.7.7.65 |
| PRIAM enzyme-specific profiles | 2.7.7.65 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.7.7.65 |
| IUBMB Enzyme Nomenclature | 2.7.7.65 |
| IntEnz | 2.7.7.65 |
| MEDLINE | Find literature relating to 2.7.7.65 |
| MetaCyc | 2.7.7.65 |
| UniProtKB/Swiss-Prot |
| P0AAP1, ADRA_ECOLI; | P0AA90, DOSC_ECO57; | P0AA89, DOSC_ECOLI; |
| Q320T0, DOSC_SHIBS; | Q0T466, DOSC_SHIF8; | Q83KV7, DOSC_SHIFL; |
| Q3Z1N3, DOSC_SHISS; | B8GZM2, PLED_CAUCN; | Q9A5I5, PLED_CAUCR; |
| P75908, YCDT_ECOLI; | P77302, YDAM_ECOLI; | P31129, YDEH_ECOLI; |
| P76237, YEAJ_ECOLI; | P76245, YEAP_ECOLI; | P76330, YEDQ_ECOLI; |
| P38097, YEGE_ECOLI; | P46139, YFIN_ECOLI; |
|
View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot
entries referenced
in this entry, with possibility to download in different formats, align etc.
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.7.7.-
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-