ENZYME entry: EC 2.7.7.65

Accepted Name
Diguanylate cyclase.
Alternative Name(s)
DGC.
Reaction catalysed
2 GTP <=> 2 diphosphate + cyclic di-3',5'-guanylate
Cofactor(s)
Mg(2+); Mn(2+).
Comment(s)
  • Can be activated by BeF3, a phosphoryl mimic, which results in dimerization.
  • Dimerization is required but is not sufficient for diguanylate- cyclase activity.
  • Cyclic di-3',5'-guanylate is an intracellular signaling molecule that controls motility and adhesion in bacterial cells; it was first identified as having a positive allosteric effect on EC 2.4.1.12.
Cross-references
BRENDA2.7.7.65
EC2PDB2.7.7.65
ExplorEnz2.7.7.65
PRIAM enzyme-specific profiles2.7.7.65
KEGG Ligand Database for Enzyme Nomenclature2.7.7.65
IUBMB Enzyme Nomenclature2.7.7.65
IntEnz2.7.7.65
MEDLINEFind literature relating to 2.7.7.65
MetaCyc2.7.7.65
UniProtKB/Swiss-Prot
P0AAP1, ADRA_ECOLI;  P0AA90, DOSC_ECO57;  P0AA89, DOSC_ECOLI;  
Q320T0, DOSC_SHIBS;  Q0T466, DOSC_SHIF8;  Q83KV7, DOSC_SHIFL;  
Q3Z1N3, DOSC_SHISS;  B8GZM2, PLED_CAUCN;  Q9A5I5, PLED_CAUCR;  
Q9KKZ4, VDCA_VIBCH;  P75908, YCDT_ECOLI;  P77302, YDAM_ECOLI;  
P31129, YDEH_ECOLI;  P76237, YEAJ_ECOLI;  P76245, YEAP_ECOLI;  
P76330, YEDQ_ECOLI;  P38097, YEGE_ECOLI;  P46139, YFIN_ECOLI;  

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