To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https

ENZYME entry: EC 2.7.7.65

Accepted Name
Diguanylate cyclase.
Alternative Name(s)
DGC.
Reaction catalysed
2 GTP <=> 2 diphosphate + cyclic di-3',5'-guanylate
Cofactor(s)
Mg(2+); Mn(2+).
Comment(s)
  • Can be activated by BeF3, a phosphoryl mimic, which results in dimerization.
  • Dimerization is required but is not sufficient for diguanylate- cyclase activity.
  • Cyclic di-3',5'-guanylate is an intracellular signaling molecule that controls motility and adhesion in bacterial cells; it was first identified as having a positive allosteric effect on EC 2.4.1.12.
Cross-references
BRENDA2.7.7.65
EC2PDB2.7.7.65
ExplorEnz2.7.7.65
PRIAM enzyme-specific profiles2.7.7.65
KEGG Ligand Database for Enzyme Nomenclature2.7.7.65
IUBMB Enzyme Nomenclature2.7.7.65
IntEnz2.7.7.65
MEDLINEFind literature relating to 2.7.7.65
MetaCyc2.7.7.65
UniProtKB/Swiss-Prot
P0AAP1, ADRA_ECOLI;  P0AA90, DOSC_ECO57;  P0AA89, DOSC_ECOLI;  
Q320T0, DOSC_SHIBS;  Q0T466, DOSC_SHIF8;  Q83KV7, DOSC_SHIFL;  
Q3Z1N3, DOSC_SHISS;  B8GZM2, PLED_CAUCN;  Q9A5I5, PLED_CAUCR;  
Q9KKZ4, VDCA_VIBCH;  P75908, YCDT_ECOLI;  P77302, YDAM_ECOLI;  
P31129, YDEH_ECOLI;  P76237, YEAJ_ECOLI;  P76245, YEAP_ECOLI;  
P76330, YEDQ_ECOLI;  P38097, YEGE_ECOLI;  P46139, YFIN_ECOLI;  

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.7.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-