ENZYME entry: EC 2.7.7.67

Accepted Name
CDP-archaeol synthase.
Reaction catalysed
CTP + 2,3-bis-O-(geranylgeranyl)-sn-glycero-1-phosphate <=> diphosphate + CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol
Cofactor(s)
Magnesium; Potassium.
Comment(s)
  • Catalyzes one of the steps in the biosynthesis of polar lipids in archaea, which are characterized by having an sn-glycero-1-phosphate backbone rather than an sn-glycero-3-phosphate backbone as is found in bacteria and eukaryotes.
  • The other enzymes involved in the biosynthesis of polar lipids in archaea are EC 1.1.1.261, EC 2.5.1.41 and EC 2.5.1.42, which together alkylate the hydroxy groups of glycerol 1-phosphate to give unsaturated archaetidic acid, which is acted upon by this enzyme to form CDP-unsaturated archaeol.
  • The final step in the pathway involves the addition of L-serine, with concomitant removal of CMP, leading to the production of unsaturated archaetidylserine.
  • Formerly EC 2.7.7.n2.
Cross-references
BRENDA2.7.7.67
EC2PDB2.7.7.67
ExplorEnz2.7.7.67
PRIAM enzyme-specific profiles2.7.7.67
KEGG Ligand Database for Enzyme Nomenclature2.7.7.67
IUBMB Enzyme Nomenclature2.7.7.67
IntEnz2.7.7.67
MEDLINEFind literature relating to 2.7.7.67
MetaCyc2.7.7.67

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