ENZYME entry: EC 2.7.7.70

Accepted Name
D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase.
Alternative Name(s)
D-glycero-D-manno-heptose-1-beta-phosphate adenylyltransferase.
Reaction catalysed
D-glycero-beta-D-manno-heptose 1-phosphate + ATP <=> ADP-D-glycero-beta-D-manno-heptose + diphosphate
Comment(s)
  • The bifunctional protein hldE includes D-glycero-beta-D-manno- heptose-7-phosphate kinase and D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase activity (cf. EC 2.7.1.167).
  • The enzyme is involved in biosynthesis of ADP-L-glycero-beta-D-manno- heptose, which is utilized for assembly of the lipopolysaccharide inner core in Gram-negative bacteria.
Cross-references
BRENDA2.7.7.70
EC2PDB2.7.7.70
ExplorEnz2.7.7.70
PRIAM enzyme-specific profiles2.7.7.70
KEGG Ligand Database for Enzyme Nomenclature2.7.7.70
IUBMB Enzyme Nomenclature2.7.7.70
IntEnz2.7.7.70
MEDLINEFind literature relating to 2.7.7.70
MetaCyc2.7.7.70
UniProtKB/Swiss-Prot
Q7WF17, HEPPA_BORBR;  A5FVE7, HLDE_ACICJ;  A3MZC0, HLDE_ACTP2;  
Q8GLU7, HLDE_ACTPL;  A6VP06, HLDE_ACTSZ;  A0KPL4, HLDE_AERHH;  
A4SIG6, HLDE_AERS4;  Q0VM60, HLDE_ALCBS;  B6ELZ7, HLDE_ALISL;  
Q0A4T7, HLDE_ALKEH;  A8EVR4, HLDE_ARCB4;  A8I5B0, HLDE_AZOC5;  
C1DGT9, HLDE_AZOVD;  Q7VQQ6, HLDE_BLOFL;  Q493X3, HLDE_BLOPB;  
Q89HR3, HLDE_BRADU;  A5EN78, HLDE_BRASB;  A4YYB6, HLDE_BRASO;  
A7ZE26, HLDE_CAMC1;  A7GZF6, HLDE_CAMC5;  A0RQR9, HLDE_CAMFF;  
A8FMK8, HLDE_CAMJ8;  A7H2L7, HLDE_CAMJD;  Q6TG09, HLDE_CAMJE;  
A1W0D6, HLDE_CAMJJ;  Q5HTW1, HLDE_CAMJR;  Q9A2C5, HLDE_CAUCR;  
B0T663, HLDE_CAUSK;  Q1R1M6, HLDE_CHRSD;  A8APT1, HLDE_CITK8;  
A9KDJ2, HLDE_COXBN;  A9N9S2, HLDE_COXBR;  Q83B60, HLDE_COXBU;  
A7MP93, HLDE_CROS8;  B8FB71, HLDE_DESAA;  A5EWS4, HLDE_DICNV;  
A7ZRT3, HLDE_ECO24;  B7UIW0, HLDE_ECO27;  B7MAC8, HLDE_ECO45;  
B7LGY7, HLDE_ECO55;  Q7AAQ7, HLDE_ECO57;  B5YR91, HLDE_ECO5E;  
B7NJR5, HLDE_ECO7I;  B7N0K1, HLDE_ECO81;  B7LZK1, HLDE_ECO8A;  
C4ZQW9, HLDE_ECOBW;  B1XG57, HLDE_ECODH;  A8A4K6, HLDE_ECOHS;  
A1AFX4, HLDE_ECOK1;  Q0TD55, HLDE_ECOL5;  Q8FDH5, HLDE_ECOL6;  
B1IRR4, HLDE_ECOLC;  P76658, HLDE_ECOLI;  B7ND40, HLDE_ECOLU;  
B6I423, HLDE_ECOSE;  B1LF43, HLDE_ECOSM;  Q1R6S9, HLDE_ECOUT;  
C5BHH2, HLDE_EDWI9;  A4WEI4, HLDE_ENT38;  B2VGJ9, HLDE_ERWT9;  
B7LQC9, HLDE_ESCF3;  B5EEZ1, HLDE_GEOBB;  B3E5M9, HLDE_GEOLS;  
Q39X60, HLDE_GEOMG;  Q74BF6, HLDE_GEOSL;  A5G6F4, HLDE_GEOUR;  
A9HDB1, HLDE_GLUDA;  Q5FS52, HLDE_GLUOX;  Q0BUU1, HLDE_GRABC;  
Q7VM30, HLDE_HAEDU;  Q4QKN8, HLDE_HAEI8;  A5UCC3, HLDE_HAEIE;  
A5UEH8, HLDE_HAEIG;  O05074, HLDE_HAEIN;  Q0I1X5, HLDE_HAES1;  
Q2SN34, HLDE_HAHCH;  A1WZB3, HLDE_HALHL;  Q17WK1, HLDE_HELAH;  
Q7VFZ3, HLDE_HELHP;  B6JM82, HLDE_HELP2;  B5Z7L8, HLDE_HELPG;  
Q1CT14, HLDE_HELPH;  Q9ZKZ0, HLDE_HELPJ;  B2USX2, HLDE_HELPS;  
O25529, HLDE_HELPY;  Q0C190, HLDE_HYPNA;  B5XU40, HLDE_KLEP3;  
A6TE31, HLDE_KLEP7;  Q1IJZ0, HLDE_KORVE;  A0L7X0, HLDE_MAGMM;  
Q2W993, HLDE_MAGSA;  Q65T41, HLDE_MANSM;  A1TYR4, HLDE_MARHV;  
A6W0Z9, HLDE_MARMS;  Q607M3, HLDE_METCA;  Q1H3A0, HLDE_METFK;  
Q1QNS3, HLDE_NITHX;  Q3J7Y0, HLDE_NITOC;  A6Q4Z6, HLDE_NITSB;  
Q3STQ8, HLDE_NITWN;  A7HUC7, HLDE_PARL1;  Q9CME6, HLDE_PASMU;  
Q6D164, HLDE_PECAS;  C6DDL3, HLDE_PECCP;  Q3A526, HLDE_PELCD;  
A1AV12, HLDE_PELPD;  Q7N0C3, HLDE_PHOLL;  Q6LUZ5, HLDE_PHOPR;  
B4EW46, HLDE_PROMH;  Q48P39, HLDE_PSE14;  A6VDB5, HLDE_PSEA7;  
B7V388, HLDE_PSEA8;  Q02F21, HLDE_PSEAB;  Q9HUG9, HLDE_PSEAE;  
Q1I411, HLDE_PSEE4;  Q4KJA9, HLDE_PSEF5;  C3KDB8, HLDE_PSEFS;  
Q3IHX7, HLDE_PSEHT;  A4XPU9, HLDE_PSEMY;  A5W9W6, HLDE_PSEP1;  
Q3KJ28, HLDE_PSEPF;  B0KL32, HLDE_PSEPG;  Q88D93, HLDE_PSEPK;  
B1J331, HLDE_PSEPW;  Q87VF4, HLDE_PSESM;  Q4ZZ15, HLDE_PSEU2;  
A4VR47, HLDE_PSEU5;  A1SZY2, HLDE_PSYIN;  Q98I54, HLDE_RHILO;  
Q2IZP7, HLDE_RHOP2;  Q07RN1, HLDE_RHOP5;  Q6N2R5, HLDE_RHOPA;  
Q219E2, HLDE_RHOPB;  Q13AN7, HLDE_RHOPS;  B3QJ47, HLDE_RHOPT;  
Q2RY67, HLDE_RHORT;  B5F696, HLDE_SALA4;  A9MPW3, HLDE_SALAR;  
Q57JQ9, HLDE_SALCH;  B5FHT5, HLDE_SALDC;  B5QZ36, HLDE_SALEP;  
B5REF8, HLDE_SALG2;  B4TI51, HLDE_SALHS;  B4T670, HLDE_SALNS;  
Q5PC86, HLDE_SALPA;  A9N5X8, HLDE_SALPB;  C0PYX3, HLDE_SALPC;  
B5BG11, HLDE_SALPK;  B4TVT4, HLDE_SALSV;  Q8XEW9, HLDE_SALTI;  
Q7CPR9, HLDE_SALTY;  A8GJU3, HLDE_SERP5;  A1S3I3, HLDE_SHEAM;  
B8EE43, HLDE_SHEB2;  A3D837, HLDE_SHEB5;  A6WJS7, HLDE_SHEB8;  
A9L2P0, HLDE_SHEB9;  Q12RC7, HLDE_SHEDO;  Q07Y78, HLDE_SHEFN;  
B0TTF2, HLDE_SHEHH;  A3QAN3, HLDE_SHELP;  Q8EAZ2, HLDE_SHEON;  
A8H086, HLDE_SHEPA;  A4Y9Z9, HLDE_SHEPC;  B8CVJ1, HLDE_SHEPW;  
A0KTG8, HLDE_SHESA;  A8FZZ3, HLDE_SHESH;  Q0HFL0, HLDE_SHESM;  
Q0HYC0, HLDE_SHESR;  A1RGD1, HLDE_SHESW;  B2U1F7, HLDE_SHIB3;  
Q31WY3, HLDE_SHIBS;  Q32BR2, HLDE_SHIDS;  Q0T0L1, HLDE_SHIF8;  
Q7UBI8, HLDE_SHIFL;  Q3YXJ0, HLDE_SHISS;  Q2NWD9, HLDE_SODGM;  
Q9Z5B5, HLDE_STRCO;  Q30T22, HLDE_SULDN;  Q31IC2, HLDE_THICR;  
A5F5J2, HLDE_VIBC3;  A7MWN3, HLDE_VIBCB;  C3LQY0, HLDE_VIBCM;  
Q5E2L7, HLDE_VIBF1;  B5FB67, HLDE_VIBFM;  Q87SJ9, HLDE_VIBPA;  
B7VIX1, HLDE_VIBTL;  Q8DEH7, HLDE_VIBVU;  Q7MNY3, HLDE_VIBVY;  
Q7M9U1, HLDE_WOLSU;  A1JQV6, HLDE_YERE8;  A7FE79, HLDE_YERP3;  
Q1C374, HLDE_YERPA;  B2K2H4, HLDE_YERPB;  Q8ZI60, HLDE_YERPE;  
A9R7D5, HLDE_YERPG;  Q1CMD4, HLDE_YERPN;  A4THT9, HLDE_YERPP;  
Q665V3, HLDE_YERPS;  B1JM26, HLDE_YERPY;  

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