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ENZYME entry: EC 2.7.7.85

Accepted Name
Diadenylate cyclase.
Alternative Name(s)
Cyclic-di-AMP synthase.
Reaction catalysed
2 ATP <=> 2 diphosphate + cyclic di-3',5'-adenylate
Comment(s)
  • Cyclic di-3',5'-adenylate is a bioactive molecule produced by some bacteria and archaea, which may function as a secondary signaling molecule.
  • The intracellular bacterial pathogen Listeria monocytogenes secretes it into the host's cytosol, where it triggers a cytosolic pathway of innate immunity.
Cross-references
BRENDA2.7.7.85
EC2PDB2.7.7.85
ExplorEnz2.7.7.85
PRIAM enzyme-specific profiles2.7.7.85
KEGG Ligand Database for Enzyme Nomenclature2.7.7.85
IUBMB Enzyme Nomenclature2.7.7.85
IntEnz2.7.7.85
MEDLINEFind literature relating to 2.7.7.85
MetaCyc2.7.7.85
UniProtKB/Swiss-Prot
Q45589, CDAA_BACSU;  O31854, CDAS_BACSU;  D5TM67, CDAS_BACT1;  
A0A0H3GM48, DACA_LISM4;  Q8Y5E4, DACA_LISMO;  P47351, DACB_MYCGE;  
P75528, DACB_MYCPN;  Q58408, DACZ_METJA;  A0LRE3, DISA_ACIC1;  
C3P9M9, DISA_BACAA;  C3LJ56, DISA_BACAC;  A0R8F5, DISA_BACAH;  
Q81VV7, DISA_BACAN;  B7JK90, DISA_BACC0;  Q73FC3, DISA_BACC1;  
B7ISZ3, DISA_BACC2;  C1ET13, DISA_BACC3;  B7HJ22, DISA_BACC4;  
B7HQR7, DISA_BACC7;  B9IZG8, DISA_BACCQ;  Q81J64, DISA_BACCR;  
Q63HB6, DISA_BACCZ;  Q9KGG0, DISA_BACHD;  Q6HPT4, DISA_BACHK;  
Q65PD4, DISA_BACLD;  A8F956, DISA_BACP2;  Q5WLT9, DISA_BACSK;  
P37573, DISA_BACSU;  A9VN96, DISA_BACWK;  C5C1B3, DISA_BEUC1;  
Q3A9N3, DISA_CARHZ;  Q97EC6, DISA_CLOAB;  A7FZ95, DISA_CLOB1;  
C3KVS9, DISA_CLOB6;  A6LPN7, DISA_CLOB8;  B2UY85, DISA_CLOBA;  
B2TIF1, DISA_CLOBB;  A5I7N4, DISA_CLOBH;  C1FNB1, DISA_CLOBJ;  
B1IGI2, DISA_CLOBK;  A7GJA2, DISA_CLOBL;  B1KTB1, DISA_CLOBM;  
A5N4M2, DISA_CLOK5;  Q8XHQ0, DISA_CLOPE;  Q0SQB6, DISA_CLOPS;  
Q890L8, DISA_CLOTE;  A3DGC7, DISA_CLOTH;  Q8FMH9, DISA_COREF;  
A4QH66, DISA_CORGB;  Q8NMB2, DISA_CORGL;  Q0RBN2, DISA_FRAAA;  
Q2J537, DISA_FRASC;  A8LF79, DISA_FRASN;  Q8RGW9, DISA_FUSNN;  
A6W5K2, DISA_KINRD;  A0QAA9, DISA_MYCA1;  Q7TW52, DISA_MYCBO;  
A1KPS2, DISA_MYCBP;  C1AI45, DISA_MYCBT;  Q743W9, DISA_MYCPA;  
A0R564, DISA_MYCS2;  A5U8R1, DISA_MYCTA;  P9WNW4, DISA_MYCTO;  
P9WNW5, DISA_MYCTU;  Q18CB2, DISA_PEPD6;  Q6AAZ9, DISA_PROAC;  
Q82EA6, DISA_STRAW;  Q9X8L6, DISA_STRCO;  B1VSK3, DISA_STRGG;  
Q67JP1, DISA_SYMTH;  Q9WY43, DISA_THEMA;  B9K6S9, DISA_THENN;  
A5IKM1, DISA_THEP1;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.7.-
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