ENZYME entry: EC 2.7.7.85

Accepted Name
Diadenylate cyclase.
Alternative Name(s)
Cyclic-di-AMP synthase.
Reaction catalysed
2 ATP <=> 2 diphosphate + cyclic di-3',5'-adenylate
Comment(s)
  • Cyclic di-3',5'-adenylate is a bioactive molecule produced by some bacteria and archaea, which may function as a secondary signaling molecule.
  • The intracellular bacterial pathogen Listeria monocytogenes secretes it into the host's cytosol, where it triggers a cytosolic pathway of innate immunity.
Cross-references
BRENDA2.7.7.85
EC2PDB2.7.7.85
ExplorEnz2.7.7.85
PRIAM enzyme-specific profiles2.7.7.85
KEGG Ligand Database for Enzyme Nomenclature2.7.7.85
IUBMB Enzyme Nomenclature2.7.7.85
IntEnz2.7.7.85
MEDLINEFind literature relating to 2.7.7.85
MetaCyc2.7.7.85
UniProtKB/Swiss-Prot
Q45589, CDAA_BACSU;  O31854, CDAS_BACSU;  D5TM67, CDAS_BACT1;  
A0A0H3GM48, DACA_LISM4;  Q8Y5E4, DACA_LISMO;  P47351, DACB_MYCGE;  
P75528, DACB_MYCPN;  A0LRE3, DISA_ACIC1;  C3P9M9, DISA_BACAA;  
C3LJ56, DISA_BACAC;  A0R8F5, DISA_BACAH;  Q81VV7, DISA_BACAN;  
B7JK90, DISA_BACC0;  Q73FC3, DISA_BACC1;  B7ISZ3, DISA_BACC2;  
C1ET13, DISA_BACC3;  B7HJ22, DISA_BACC4;  B7HQR7, DISA_BACC7;  
B9IZG8, DISA_BACCQ;  Q81J64, DISA_BACCR;  Q63HB6, DISA_BACCZ;  
Q9KGG0, DISA_BACHD;  Q6HPT4, DISA_BACHK;  Q65PD4, DISA_BACLD;  
A8F956, DISA_BACP2;  Q5WLT9, DISA_BACSK;  P37573, DISA_BACSU;  
A9VN96, DISA_BACWK;  C5C1B3, DISA_BEUC1;  Q3A9N3, DISA_CARHZ;  
Q97EC6, DISA_CLOAB;  A7FZ95, DISA_CLOB1;  C3KVS9, DISA_CLOB6;  
A6LPN7, DISA_CLOB8;  B2UY85, DISA_CLOBA;  B2TIF1, DISA_CLOBB;  
A5I7N4, DISA_CLOBH;  C1FNB1, DISA_CLOBJ;  B1IGI2, DISA_CLOBK;  
A7GJA2, DISA_CLOBL;  B1KTB1, DISA_CLOBM;  A5N4M2, DISA_CLOK5;  
Q8XHQ0, DISA_CLOPE;  Q0SQB6, DISA_CLOPS;  Q890L8, DISA_CLOTE;  
A3DGC7, DISA_CLOTH;  Q8FMH9, DISA_COREF;  A4QH66, DISA_CORGB;  
Q8NMB2, DISA_CORGL;  Q0RBN2, DISA_FRAAA;  Q2J537, DISA_FRASC;  
A8LF79, DISA_FRASN;  Q8RGW9, DISA_FUSNN;  A6W5K2, DISA_KINRD;  
A0QAA9, DISA_MYCA1;  Q7TW52, DISA_MYCBO;  A1KPS2, DISA_MYCBP;  
C1AI45, DISA_MYCBT;  Q743W9, DISA_MYCPA;  A0R564, DISA_MYCS2;  
A5U8R1, DISA_MYCTA;  P9WNW4, DISA_MYCTO;  P9WNW5, DISA_MYCTU;  
Q18CB2, DISA_PEPD6;  Q6AAZ9, DISA_PROAC;  Q82EA6, DISA_STRAW;  
Q9X8L6, DISA_STRCO;  B1VSK3, DISA_STRGG;  Q67JP1, DISA_SYMTH;  
Q9WY43, DISA_THEMA;  B9K6S9, DISA_THENN;  A5IKM1, DISA_THEP1;  

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