ENZYME entry: EC 2.7.8.27
| Accepted Name |
|---|
| Sphingomyelin synthase.
|
| Alternative Name(s) |
|---|
| Phosphatidylcholine:ceramide cholinephosphotransferase. |
| SM synthase. |
| Reaction catalysed |
|---|
| A ceramide + a phosphatidylcholine <=> a sphingomyelin + a 1,2-diacyl-sn-glycerol |
| Comment(s) |
|---|
- The reaction can occur in both directions.
- Occupies a central position in sphingolipid and glycerophospholipid
metabolism.
- Up- and down-regulation of its activity has been linked to mitogenic
and pro-apoptotic signaling in a variety of mammalian cell types.
- Unlike EC 2.7.8.3 CDP-choline cannot replace phosphatidylcholine as
the donor of the phosphocholine moiety of sphingomyelin.
|
| Cross-references |
|---|
| BRENDA | 2.7.8.27 |
| EC2PDB | 2.7.8.27 |
| ExplorEnz | 2.7.8.27 |
| PRIAM enzyme-specific profiles | 2.7.8.27 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.7.8.27 |
| IUBMB Enzyme Nomenclature | 2.7.8.27 |
| IntEnz | 2.7.8.27 |
| MEDLINE | Find literature relating to 2.7.8.27 |
| MetaCyc | 2.7.8.27 |
| UniProtKB/Swiss-Prot |
| Q38E55, SLS3_TRYB2; | B3A0M1, SLS3_TRYBB; | Q38E56, SLS4_TRYB2; |
| B3A0M2, SLS4_TRYBB; | Q9U3D4, SMS1_CAEEL; | Q7T3T4, SMS1_CHICK; |
| Q86VZ5, SMS1_HUMAN; | Q8VCQ6, SMS1_MOUSE; | A0AAS4, SMS1_PIG; |
| Q7TSX5, SMS1_RAT; | Q20735, SMS2_CAEEL; | Q8NHU3, SMS2_HUMAN; |
| Q4R763, SMS2_MACFA; | Q9D4B1, SMS2_MOUSE; | Q4JM44, SMS2_RAT; |
| Q965Q4, SMS3_CAEEL; |
|
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