ENZYME entry: EC 2.7.8.33

Accepted Name
UDP-N-acetylglucosamine--undecaprenyl-phosphate N-acetylglucosaminephosphotransferase.
Alternative Name(s)
UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase.
Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase.
Reaction catalysed
UDP-N-acetyl-alpha-D-glucosamine + ditrans,octacis-undecaprenyl phosphate <=> UMP + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
Comment(s)
  • This enzyme catalyzes the synthesis of N-acetyl-alpha-D-glucosaminyl- diphospho-ditrans,octacis-undecaprenol, an essential lipid intermediate for the biosynthesis of various bacterial cell envelope components.
  • The enzyme also initiates the biosynthesis of enterobacterial common antigen and O-antigen lipopolysaccharide in certain Escherichia coli strains, including K-12 and of teichoic acid in certain Gram-positive bacteria.
  • Formerly EC 2.7.8.n2.
Cross-references
BRENDA2.7.8.33
EC2PDB2.7.8.33
ExplorEnz2.7.8.33
PRIAM enzyme-specific profiles2.7.8.33
KEGG Ligand Database for Enzyme Nomenclature2.7.8.33
IUBMB Enzyme Nomenclature2.7.8.33
IntEnz2.7.8.33
MEDLINEFind literature relating to 2.7.8.33
MetaCyc2.7.8.33
UniProtKB/Swiss-Prot
O34753, TAGO_BACSU;  Q8XAS7, WECA_ECO57;  P0AC79, WECA_ECOL6;  
P0AC78, WECA_ECOLI;  P45341, WECA_HAEIN;  Q9CNG8, WECA_PASMU;  
Q8Z386, WECA_SALTI;  Q9L6R7, WECA_SALTY;  P0AC80, WECA_SHIFL;  
Q9X1N5, WECA_THEMA;  Q8ZAE1, WECA_YERPE;  

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