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ENZYME

ENZYME entry: EC 2.7.8.48

Accepted Name
ceramide phosphoethanolamine synthase
Alternative Name(s)
CPE synthase
Reaction catalysed
an N-acyl-sphingoid base + CDP-ethanolamine <=> an N-acyl-sphingoid 1-phosphoethanolamine + CMP + H(+)
Comment(s)
  • The enzyme, studied from the fly Drosophila melanogaster, has homologs among the invertebrates, but not in other animal phyla.
  • Its product, ceramide phosphoethanolamine, is synthesized as the main sphingolipid in cell membranes of arthropods, such as Drosophila and Musca, and is common in worms, bees, spiders, and scorpions.
  • It has also been reported in deep-sea mussels and some sea snails, as well as protozoans and oomycetes.
  • The enzyme requires a Mn(II) cofactor.
  • Formerly EC 2.7.8.n3.
Cross-references
BRENDA2.7.8.48
EC2PDB2.7.8.48
ExplorEnz2.7.8.48
PRIAM enzyme-specific profiles2.7.8.48
KEGG Ligand Database for Enzyme Nomenclature2.7.8.48
IUBMB Enzyme Nomenclature2.7.8.48
IntEnz2.7.8.48
MEDLINEFind literature relating to 2.7.8.48
MetaCyc2.7.8.48
Rhea expert-curated reactions2.7.8.48
UniProtKB/Swiss-Prot
O77475, CPESY_DROME

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