ENZYME entry: EC 2.7.8.5

Accepted Name
CDP-diacylglycerol--glycerol-3-phosphate 1-phosphatidyltransferase.
Alternative Name(s)
3-phosphatidyl-1'-glycerol-3'-phosphate synthase.
Glycerophosphate phosphatidyltransferase.
PGP synthase.
Phosphatidylglycerophosphate synthase.
Reaction catalysed
CDP-diacylglycerol + sn-glycerol 3-phosphate <=> CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate
Comment(s)
The enzyme catalyzes the committed step in the biosynthesis of acidic phospholipids known by the common names phophatidylglycerols and cardiolipins.
Cross-references
PROSITEPDOC00321
BRENDA2.7.8.5
EC2PDB2.7.8.5
ExplorEnz2.7.8.5
PRIAM enzyme-specific profiles2.7.8.5
KEGG Ligand Database for Enzyme Nomenclature2.7.8.5
IUBMB Enzyme Nomenclature2.7.8.5
IntEnz2.7.8.5
MEDLINEFind literature relating to 2.7.8.5
MetaCyc2.7.8.5
UniProtKB/Swiss-Prot
O80952, PGPS1_ARATH;  Q2KJ28, PGPS1_BOVIN;  Q5ZHN9, PGPS1_CHICK;  
Q9Z2Z7, PGPS1_CRIGR;  Q7KWX2, PGPS1_DICDI;  Q32NB8, PGPS1_HUMAN;  
Q8BHF7, PGPS1_MOUSE;  Q5N9A1, PGPS1_ORYSJ;  Q5R8K7, PGPS1_PONAB;  
P79001, PGPS1_SACPS;  Q9HDW1, PGPS1_SCHPO;  P25578, PGPS1_YEAST;  
Q9M2W3, PGPS2_ARATH;  P9WPG4, PGSA1_MYCTO;  P9WPG5, PGSA1_MYCTU;  
P9WPG2, PGSA2_MYCTO;  P9WPG3, PGSA2_MYCTU;  O67908, PGSA_AQUAE;  
P46322, PGSA_BACSU;  Q7VR12, PGSA_BLOFL;  Q492P7, PGSA_BLOPB;  
P0ABG0, PGSA_ECO57;  A1AC64, PGSA_ECOK1;  Q0TGS6, PGSA_ECOL5;  
P0ABF9, PGSA_ECOL6;  P0ABF8, PGSA_ECOLI;  Q1RAM8, PGSA_ECOUT;  
P44528, PGSA_HAEIN;  P63754, PGSA_MYCBO;  P47360, PGSA_MYCGE;  
P75520, PGSA_MYCPN;  Q6D364, PGSA_PECAS;  Q7N5C8, PGSA_PHOLL;  
P45419, PGSA_PSEFL;  Q3IYX7, PGSA_RHOS4;  Q1RKM3, PGSA_RICBR;  
Q92JJ2, PGSA_RICCN;  Q4UN77, PGSA_RICFE;  Q9ZE96, PGSA_RICPR;  
Q68XS5, PGSA_RICTY;  Q57N57, PGSA_SALCH;  Q5PI18, PGSA_SALPA;  
Q8XFD0, PGSA_SALTI;  Q7CQB9, PGSA_SALTY;  Q322L9, PGSA_SHIBS;  
Q32HD9, PGSA_SHIDS;  Q0T3L5, PGSA_SHIF8;  Q83R47, PGSA_SHIFL;  
Q3Z2T6, PGSA_SHISS;  Q2NTS8, PGSA_SODGM;  Q5HGE8, PGSA_STAAC;  
P63755, PGSA_STAAM;  P63756, PGSA_STAAN;  Q6GHF2, PGSA_STAAR;  
Q6G9T0, PGSA_STAAS;  P63757, PGSA_STAAW;  Q5HPQ8, PGSA_STAEQ;  
Q8CPF7, PGSA_STAES;  O66076, PGSA_TREPA;  Q8D2N9, PGSA_WIGBR;  
A1JLU9, PGSA_YERE8;  Q1C8L0, PGSA_YERPA;  Q8ZF51, PGSA_YERPE;  
Q1CHE5, PGSA_YERPN;  A4TK40, PGSA_YERPP;  Q66BN4, PGSA_YERPS;  

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