ENZYME entry: EC 2.8.1.10

Accepted Name
Thiazole synthase.
Reaction catalysed
1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + thiocarboxy-adenylate-[sulfur-carrier protein ThiS] <=> 2-((2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate + [sulfur-carrier protein ThiS] + 2 H(2)O
Comment(s)
  • H(2)S can provide the sulfur in vitro.
  • Part of the pathway for thiamine biosynthesis.
Cross-references
BRENDA2.8.1.10
EC2PDB2.8.1.10
ExplorEnz2.8.1.10
PRIAM enzyme-specific profiles2.8.1.10
KEGG Ligand Database for Enzyme Nomenclature2.8.1.10
IUBMB Enzyme Nomenclature2.8.1.10
IntEnz2.8.1.10
MEDLINEFind literature relating to 2.8.1.10
MetaCyc2.8.1.10
UniProtKB/Swiss-Prot
Q3A7P5, THIG1_PELCD;  Q3A6Y9, THIG2_PELCD;  B0C390, THIG_ACAM1;  
A1TRP8, THIG_ACIAC;  Q6FCN1, THIG_ACIAD;  B7GZV4, THIG_ACIB3;  
B7I2M9, THIG_ACIB5;  B2HUU9, THIG_ACIBC;  B0VKA4, THIG_ACIBS;  
A3M6Z4, THIG_ACIBT;  B0V876, THIG_ACIBY;  B7J5U0, THIG_ACIF2;  
B5ENK9, THIG_ACIF5;  A4SSI2, THIG_AERS4;  Q8UCD2, THIG_AGRFC;  
B9JMX8, THIG_AGRRK;  B9K256, THIG_AGRVS;  B6EGV5, THIG_ALISL;  
Q0ACP4, THIG_ALKEH;  A6TVU7, THIG_ALKMQ;  B4S2W0, THIG_ALTMD;  
B8JH75, THIG_ANAD2;  Q2IKW1, THIG_ANADE;  A7HA08, THIG_ANADF;  
B4UIG2, THIG_ANASK;  B7GEY2, THIG_ANOFW;  O67926, THIG_AQUAE;  
A8ER78, THIG_ARCB4;  Q5P5J1, THIG_AROAE;  A8IEY6, THIG_AZOC5;  
A1KCM9, THIG_AZOSB;  C1DI61, THIG_AZOVD;  C3P0L4, THIG_BACAA;  
C3LFA6, THIG_BACAC;  A0RA08, THIG_BACAH;  Q81UX4, THIG_BACAN;  
B7JRB1, THIG_BACC0;  Q73DB1, THIG_BACC1;  B7IY02, THIG_BACC2;  
C1EYJ3, THIG_BACC3;  B7HDF2, THIG_BACC4;  B7HWF4, THIG_BACC7;  
A7GLF8, THIG_BACCN;  B9J523, THIG_BACCQ;  Q81HQ5, THIG_BACCR;  
Q63FR5, THIG_BACCZ;  Q5LCA6, THIG_BACFN;  Q64TA0, THIG_BACFR;  
Q9KCY6, THIG_BACHD;  Q6HN84, THIG_BACHK;  Q65L94, THIG_BACLD;  
A8FC15, THIG_BACP2;  Q5WH85, THIG_BACSK;  O31618, THIG_BACSU;  
Q8AA14, THIG_BACTN;  A6L646, THIG_BACV8;  A7Z3F8, THIG_BACVZ;  
A9VFL4, THIG_BACWK;  A1US08, THIG_BARBK;  Q6G480, THIG_BARHE;  
Q6G0A2, THIG_BARQU;  A9IRH0, THIG_BART1;  Q1LU41, THIG_BAUCH;  
Q8G5F6, THIG_BIFLO;  Q2KUI1, THIG_BORA1;  Q7WF21, THIG_BORBR;  
Q7W3P5, THIG_BORPA;  Q7VTE5, THIG_BORPE;  Q89FP2, THIG_BRADU;  
A5EPQ3, THIG_BRASB;  A4YZQ4, THIG_BRASO;  B2S8J9, THIG_BRUA1;  
Q2YP58, THIG_BRUA2;  Q57FG5, THIG_BRUAB;  A9M7F3, THIG_BRUC2;  
C0RGR3, THIG_BRUMB;  Q8YEZ2, THIG_BRUME;  A5VNE4, THIG_BRUO2;  
B0CJ70, THIG_BRUSI;  Q8G2U9, THIG_BRUSU;  Q39KA4, THIG_BURL3;  
Q62GC6, THIG_BURMA;  Q3JMY2, THIG_BURP1;  Q63Q73, THIG_BURPS;  
Q2SU89, THIG_BURTA;  A8FM94, THIG_CAMJ8;  A7H2Z6, THIG_CAMJD;  
Q9PNP6, THIG_CAMJE;  A1W035, THIG_CAMJJ;  Q5HU56, THIG_CAMJR;  
B8GWN0, THIG_CAUCN;  Q9A746, THIG_CAUCR;  B0SXB0, THIG_CAUSK;  
B3PIG8, THIG_CELJU;  Q3AR47, THIG_CHLCH;  B3EH68, THIG_CHLL2;  
B3QMD7, THIG_CHLP8;  B3EK52, THIG_CHLPB;  A1BEF7, THIG_CHLPD;  
A4SFW2, THIG_CHLPM;  B3QUZ7, THIG_CHLT3;  Q8KEJ1, THIG_CHLTE;  
Q7NRL4, THIG_CHRVO;  A8AKT3, THIG_CITK8;  P58262, THIG_CLOAB;  
A6LTL5, THIG_CLOB8;  A5N8P8, THIG_CLOK5;  Q0TQ02, THIG_CLOP1;  
Q8XK02, THIG_CLOPE;  Q0SSM0, THIG_CLOPS;  Q893R2, THIG_CLOTE;  
A3DD04, THIG_CLOTH;  Q48A93, THIG_COLP3;  C3PH66, THIG_CORA7;  
Q6NKI6, THIG_CORDI;  Q8FP52, THIG_COREF;  A4QFA8, THIG_CORGB;  
Q8NNY6, THIG_CORGL;  Q4JVZ5, THIG_CORJK;  B1VH27, THIG_CORU7;  
B6J5W6, THIG_COXB1;  B6J1X5, THIG_COXB2;  A9KGN4, THIG_COXBN;  
A9NB65, THIG_COXBR;  Q83EI7, THIG_COXBU;  A7MQQ2, THIG_CROS8;  
Q1LS25, THIG_CUPMC;  Q0KF31, THIG_CUPNH;  Q476U3, THIG_CUPPJ;  
B2AGF6, THIG_CUPTR;  O19915, THIG_CYACA;  Q85G31, THIG_CYAM1;  
Q11YI1, THIG_CYTH3;  Q478Z2, THIG_DECAR;  Q1IX18, THIG_DEIGD;  
Q9RYY1, THIG_DEIRA;  Q311P4, THIG_DESAG;  Q6AMF7, THIG_DESPS;  
A4J0M0, THIG_DESRM;  A7ZUK5, THIG_ECO24;  B7UPE5, THIG_ECO27;  
B7MIX6, THIG_ECO45;  B7LA84, THIG_ECO55;  P58263, THIG_ECO57;  
B7NRS3, THIG_ECO7I;  B7N2J2, THIG_ECO81;  B7M738, THIG_ECO8A;  
C5A0T1, THIG_ECOBW;  B1XBZ3, THIG_ECODH;  A8A790, THIG_ECOHS;  
Q0TA75, THIG_ECOL5;  Q8FB81, THIG_ECOL6;  B1IUQ7, THIG_ECOLC;  
P30139, THIG_ECOLI;  B7NFT1, THIG_ECOLU;  B6I5K1, THIG_ECOSE;  
Q4G387, THIG_EMIHU;  A4W5B3, THIG_ENT38;  Q9F812, THIG_ERWAM;  
Q8GEI4, THIG_ERWPE;  B2VD79, THIG_ERWT9;  B7LUL2, THIG_ESCF3;  
B1YES2, THIG_EXIS2;  A6GWS0, THIG_FLAPJ;  Q2J8F9, THIG_FRASC;  
A8LFH1, THIG_FRASN;  Q8RI63, THIG_FUSNN;  B5ED95, THIG_GEOBB;  
Q5L2C0, THIG_GEOKA;  Q39RH2, THIG_GEOMG;  Q74FL9, THIG_GEOSL;  
C6E0C4, THIG_GEOSM;  C5D6J1, THIG_GEOSW;  A4IKR6, THIG_GEOTN;  
A5G7P4, THIG_GEOUR;  Q7NJM5, THIG_GLOVI;  A9HI56, THIG_GLUDA;  
Q5FNT5, THIG_GLUOX;  Q6B924, THIG_GRATL;  Q2SQL5, THIG_HAHCH;  
Q7VF28, THIG_HELHP;  B0TG92, THIG_HELMI;  Q5R146, THIG_IDILO;  
B5XYE8, THIG_KLEP3;  A6TGP7, THIG_KLEP7;  Q5X4Z5, THIG_LEGPA;  
A5IC64, THIG_LEGPC;  Q5WWJ5, THIG_LEGPL;  B9E9B4, THIG_MACCJ;  
A0L5E8, THIG_MAGMM;  Q2W3R9, THIG_MAGSA;  Q0AQ76, THIG_MARMM;  
A6VXY2, THIG_MARMS;  Q609Z5, THIG_METCA;  Q1GXY7, THIG_METFK;  
B8IPG1, THIG_METNO;  B0UHP4, THIG_METS4;  Q2RHX4, THIG_MOOTA;  
A0QLT3, THIG_MYCA1;  P59948, THIG_MYCBO;  A1KFN9, THIG_MYCBP;  
C1AK93, THIG_MYCBT;  B8ZU92, THIG_MYCLB;  Q9ZBL2, THIG_MYCLE;  
B2HQ02, THIG_MYCMM;  Q73T20, THIG_MYCPA;  A0QQL0, THIG_MYCS2;  
A5TZE3, THIG_MYCTA;  P9WG72, THIG_MYCTO;  P9WG73, THIG_MYCTU;  
A0PRX9, THIG_MYCUA;  Q1D7A6, THIG_MYXXD;  B9L7B6, THIG_NAUPA;  
Q5F5C4, THIG_NEIG1;  A9M072, THIG_NEIM0;  Q9JWI4, THIG_NEIMA;  
Q9JXF5, THIG_NEIMB;  A1KWF0, THIG_NEIMF;  Q2GDS9, THIG_NEOSM;  
Q0AJ67, THIG_NITEC;  Q82XI7, THIG_NITEU;  Q1QJD6, THIG_NITHX;  
Q2YCZ2, THIG_NITMU;  Q3JAP1, THIG_NITOC;  A6Q1C9, THIG_NITSB;  
Q3SPS2, THIG_NITWN;  Q5YNQ2, THIG_NOCFA;  Q2G348, THIG_NOVAD;  
A6WVK9, THIG_OCHA4;  P49570, THIG_ODOSI;  A1AY12, THIG_PARDP;  
Q6DAM4, THIG_PECAS;  C6DHS2, THIG_PECCP;  B4SCL0, THIG_PELPB;  
A5D4K1, THIG_PELTS;  Q4FMP0, THIG_PELUB;  Q186R1, THIG_PEPD6;  
C0QUK5, THIG_PERMH;  A0T0L1, THIG_PHATC;  B4RCS1, THIG_PHEZH;  
Q7N966, THIG_PHOLL;  Q6LVX7, THIG_PHOPR;  B2RH32, THIG_PORG3;  
Q7MT73, THIG_PORGI;  P51361, THIG_PORPU;  Q6AAE4, THIG_PROAC;  
A3PFF2, THIG_PROM0;  A2C5C9, THIG_PROM1;  A8G7G9, THIG_PROM2;  
A2BZ50, THIG_PROM5;  Q317X8, THIG_PROM9;  Q7V9K9, THIG_PROMA;  
B4EYU5, THIG_PROMH;  Q7V9A2, THIG_PROMM;  Q7UZJ9, THIG_PROMP;  
A2BTP5, THIG_PROMS;  Q46IC6, THIG_PROMT;  Q48CL9, THIG_PSE14;  
A6UYJ0, THIG_PSEA7;  B7V3W7, THIG_PSEA8;  Q02U32, THIG_PSEAB;  
Q9I6B4, THIG_PSEAE;  Q1IGD3, THIG_PSEE4;  Q4K4C5, THIG_PSEF5;  
C3K3L7, THIG_PSEFS;  Q3IFN6, THIG_PSEHT;  A4XZZ8, THIG_PSEMY;  
A5WAD7, THIG_PSEP1;  Q3K587, THIG_PSEPF;  B0KN58, THIG_PSEPG;  
Q88CS6, THIG_PSEPK;  B1J2G8, THIG_PSEPW;  Q88AF6, THIG_PSESM;  
Q4ZM55, THIG_PSEU2;  A4VRK5, THIG_PSEU5;  Q4FV61, THIG_PSYA2;  
Q1QE71, THIG_PSYCK;  Q1XDC6, THIG_PYRYE;  B2U764, THIG_RALPJ;  
Q8Y372, THIG_RALSO;  O34293, THIG_RHIEC;  Q98AZ6, THIG_RHILO;  
P58264, THIG_RHIME;  Q7US84, THIG_RHOBA;  Q2IYP6, THIG_RHOP2;  
Q07PW9, THIG_RHOP5;  Q6N3W7, THIG_RHOPA;  Q216G8, THIG_RHOPB;  
Q133T5, THIG_RHOPS;  B3QFS7, THIG_RHOPT;  Q2RRL3, THIG_RHORT;  
Q16C60, THIG_ROSDO;  Q5LWJ1, THIG_RUEPO;  B5F1H3, THIG_SALA4;  
A8M4E3, THIG_SALAI;  A9MHE0, THIG_SALAR;  Q57H64, THIG_SALCH;  
B5QYE5, THIG_SALEP;  B5RFJ4, THIG_SALG2;  Q5PK87, THIG_SALPA;  
A9N0K2, THIG_SALPB;  C0Q2S2, THIG_SALPC;  B5BJQ9, THIG_SALPK;  
Q2S371, THIG_SALRD;  B4TQK0, THIG_SALSV;  Q8Z322, THIG_SALTI;  
Q9L9J1, THIG_SALTY;  A8G8F0, THIG_SERP5;  A1S6Q5, THIG_SHEAM;  
B8EA59, THIG_SHEB2;  A3D465, THIG_SHEB5;  A6WNR8, THIG_SHEB8;  
A9L3J3, THIG_SHEB9;  Q12NB8, THIG_SHEDO;  Q081M2, THIG_SHEFN;  
B0TS89, THIG_SHEHH;  A3QER0, THIG_SHELP;  Q8EEE1, THIG_SHEON;  
A8H562, THIG_SHEPA;  A4Y6R6, THIG_SHEPC;  B8CNW1, THIG_SHEPW;  
A0KWK2, THIG_SHESA;  A8FUV3, THIG_SHESH;  Q0HJ08, THIG_SHESM;  
Q0HUX4, THIG_SHESR;  A1RJR5, THIG_SHESW;  B1KHI0, THIG_SHEWM;  
B2TWH8, THIG_SHIB3;  Q31U06, THIG_SHIBS;  Q32AG3, THIG_SHIDS;  
Q83PC0, THIG_SHIFL;  Q3YUZ4, THIG_SHISS;  Q01NZ1, THIG_SOLUE;  
A9EXF3, THIG_SORC5;  B9DKG1, THIG_STACT;  Q5HLB4, THIG_STAEQ;  
Q8CN30, THIG_STAES;  Q4L904, THIG_STAHJ;  Q49UF2, THIG_STAS1;  
Q82AG5, THIG_STRAW;  Q9S2N4, THIG_STRCO;  B1VZU6, THIG_STRGG;  
B4STS6, THIG_STRM5;  B2FSD0, THIG_STRMK;  Q30U33, THIG_SULDN;  
B2V959, THIG_SULSY;  Q31QR1, THIG_SYNE7;  A0LJA4, THIG_SYNFM;  
Q5N3I3, THIG_SYNP6;  A5GHR6, THIG_SYNPW;  Q7UA46, THIG_SYNPX;  
Q3B0V2, THIG_SYNS9;  Q3ANJ9, THIG_SYNSC;  A0T103, THIG_THAPS;  
Q8DMP6, THIG_THEEB;  Q47R37, THIG_THEFY;  Q72KN9, THIG_THET2;  
Q5SKG7, THIG_THET8;  B5YJ73, THIG_THEYD;  Q31JD2, THIG_THICR;  
Q3SH10, THIG_THIDA;  B8GQT0, THIG_THISH;  Q112X4, THIG_TRIEI;  
C5CJH0, THIG_VARPS;  A5CVZ0, THIG_VESOH;  A5F4E2, THIG_VIBC3;  
A7N137, THIG_VIBCB;  Q9KVS4, THIG_VIBCH;  C3LPQ7, THIG_VIBCM;  
Q5E8W6, THIG_VIBF1;  B5FF70, THIG_VIBFM;  Q87KF4, THIG_VIBPA;  
B7VMV3, THIG_VIBTL;  Q8DDL8, THIG_VIBVU;  Q7MGM7, THIG_VIBVY;  
Q8D249, THIG_WIGBR;  Q7M9F6, THIG_WOLSU;  Q8PHF5, THIG_XANAC;  
Q3BQ15, THIG_XANC5;  Q4UXY4, THIG_XANC8;  B0RPJ1, THIG_XANCB;  
Q8P632, THIG_XANCP;  Q2P0J5, THIG_XANOM;  B2SWK7, THIG_XANOP;  
Q5GXE5, THIG_XANOR;  Q9PF95, THIG_XYLFA;  Q87AE8, THIG_XYLFT;  
A1JII4, THIG_YERE8;  A7FNH9, THIG_YERP3;  Q1C1U5, THIG_YERPA;  
B2K116, THIG_YERPB;  Q8ZAP9, THIG_YERPE;  Q1CN74, THIG_YERPN;  
Q66FP9, THIG_YERPS;  B1JJK2, THIG_YERPY;  Q5NPJ8, THIG_ZYMMO;  
Q3M859, THIOG_ANAVT;  Q8YRC9, THIOG_NOSS1;  Q55710, THIOG_SYNY3;  

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