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ENZYME entry: EC 2.8.1.11

Accepted Name
Molybdopterin synthase sulfurtransferase.
Alternative Name(s)
Molybdopterin synthase sulfurylase.
Reaction catalysed
[Molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine desulfurase]-S-sulfanyl-L-cysteine + reduced acceptor <=> AMP + [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH + [cysteine desulfurase] + oxidized acceptor
Comment(s)
  • The enzyme transfers sulfur to form a thiocarboxylate moiety on the C-terminal glycine of the small subunit of EC 2.8.1.12.
  • In the human, the reaction is catalyzed by the rhodanese-like C-terminal domain (cf. EC 2.8.1.1) of the MOCS3 protein, a bifunctional protein that also contains EC 2.7.7.80 at the N-terminal domain.
  • Formerly EC 2.8.1.n1.
Cross-references
BRENDA2.8.1.11
EC2PDB2.8.1.11
ExplorEnz2.8.1.11
PRIAM enzyme-specific profiles2.8.1.11
KEGG Ligand Database for Enzyme Nomenclature2.8.1.11
IUBMB Enzyme Nomenclature2.8.1.11
IntEnz2.8.1.11
MEDLINEFind literature relating to 2.8.1.11
MetaCyc2.8.1.11
UniProtKB/Swiss-Prot
B5DS72, MOC31_DROPS;  B6TNK6, MOC31_MAIZE;  Q29PG5, MOC32_DROPS;  
B4FAT0, MOC32_MAIZE;  Q17CA7, MOCS3_AEDAE;  Q7PY41, MOCS3_ANOGA;  
Q9ZNW0, MOCS3_ARATH;  A1A4L8, MOCS3_BOVIN;  A8WRE3, MOCS3_CAEBR;  
O44510, MOCS3_CAEEL;  B0W377, MOCS3_CULQU;  Q8AWD2, MOCS3_DANRE;  
B3MLX7, MOCS3_DROAN;  B4JBC4, MOCS3_DROGR;  Q9VLJ8, MOCS3_DROME;  
B4KI53, MOCS3_DROMO;  B4GKQ3, MOCS3_DROPE;  B4HYP0, MOCS3_DROSE;  
B4LRB9, MOCS3_DROVI;  B4N7R4, MOCS3_DROWI;  B4NXF7, MOCS3_DROYA;  
O95396, MOCS3_HUMAN;  A2BDX3, MOCS3_MOUSE;  A3ACF3, MOCS3_ORYSJ;  
A5GFZ6, MOCS3_PIG;  Q58E95, MOCS3_XENLA;  A1CAZ7, UBA4_ASPCL;  
B0Y0P7, UBA4_ASPFC;  Q4WV19, UBA4_ASPFU;  A2R3H4, UBA4_ASPNC;  
Q2TWN3, UBA4_ASPOR;  Q0CFD4, UBA4_ASPTN;  Q55FS0, UBA4_DICDI;  
O59954, UBA4_EMENI;  A4RPM5, UBA4_MAGO7;  A1DED8, UBA4_NEOFI;  
A7F582, UBA4_SCLS1;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.8.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.8.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-