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ENZYME

ENZYME entry: EC 2.8.1.4

Accepted Name
tRNA uracil 4-sulfurtransferase
Alternative Name(s)
tRNA sulfurtransferase
Reaction catalysed
[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]
Comment(s)
  • The enzyme, found in bacteria and archaea, is activated by EC 2.8.1.7, which transfers a sulfur atom to an internal L-cysteine residue, forming a cysteine persulfide.
  • The activated enzyme then transfers the sulfur to a uridine in a tRNA chain in a reaction that requires ATP.
  • The enzyme from the bacterium Escherichia coli forms 4-thiouridine only at position 8 of tRNA.
  • The enzyme also participates in the biosynthesis of the thiazole moiety of thiamine, but different domains are involved in the two processes.
Cross-references
BRENDA2.8.1.4
EC2PDB2.8.1.4
ExplorEnz2.8.1.4
PRIAM enzyme-specific profiles2.8.1.4
KEGG Ligand Database for Enzyme Nomenclature2.8.1.4
IUBMB Enzyme Nomenclature2.8.1.4
IntEnz2.8.1.4
MEDLINEFind literature relating to 2.8.1.4
MetaCyc2.8.1.4
Rhea expert-curated reactions2.8.1.4
UniProtKB/Swiss-Prot
A3DEB6, THII_ACET2A9NHG7, THII_ACHLIA6VQ53, THII_ACTSZ
A0KIY0, THII_AERHHQ9YEW8, THII_AERPEA4SP64, THII_AERS4
C4ZAY9, THII_AGARVQ5E6Y5, THII_ALIF1B5FBH1, THII_ALIFM
B6EIB2, THII_ALISLA6TQ96, THII_ALKMQA8MHS1, THII_ALKOO
B7GGQ4, THII_ANOFWO29382, THII_ARCFUC1DHW2, THII_AZOVD
C3PBB3, THII_BACAAC3L9V4, THII_BACACA0RJN9, THII_BACAH
Q81KU0, THII_BACANB7JS23, THII_BACC0Q72Z85, THII_BACC1
B7IK47, THII_BACC2C1EUZ5, THII_BACC3B7H703, THII_BACC4
B7HSI4, THII_BACC7A7GTS8, THII_BACCNB9J151, THII_BACCQ
Q817B1, THII_BACCRQ633E8, THII_BACCZQ6HCN0, THII_BACHK
Q65G52, THII_BACLDA8FG94, THII_BACP2O34595, THII_BACSU
A7Z7N3, THII_BACVZQ493G5, THII_BLOPBC0ZH32, THII_BREBN
Q8R9F0, THII_CALS4A8AK31, THII_CITK8Q97EY4, THII_CLOAB
B2UX29, THII_CLOBAQ189U8, THII_CLOD6B9DZV9, THII_CLOK1
A5N6D9, THII_CLOK5Q0TQI5, THII_CLOP1Q8XKI3, THII_CLOPE
Q0ST36, THII_CLOPSQ487C7, THII_COLP3Q83CD9, THII_COXBU
B8D4I6, THII_DESA1A7ZIH7, THII_ECO24B7UJP6, THII_ECO27
B7MD81, THII_ECO45B7L657, THII_ECO55Q8XE74, THII_ECO57
B5Z3S9, THII_ECO5EB7NJ74, THII_ECO7IB7MQD8, THII_ECO81
B7M3R2, THII_ECO8AC4ZTI0, THII_ECOBWB1XF11, THII_ECODH
A7ZX76, THII_ECOHSA1A892, THII_ECOK1Q8FKB7, THII_ECOL6
B1J026, THII_ECOLCP77718, THII_ECOLIB7N8X6, THII_ECOLU
B6HZM6, THII_ECOSEB1LJH3, THII_ECOSMQ1RFB7, THII_ECOUT
C5BCI2, THII_EDWI9Q82ZW3, THII_ENTFAB2VHS0, THII_ERWT9
B7LMG4, THII_ESCF3B0RZV0, THII_FINM2Q5KW56, THII_GEOKA
C5D693, THII_GEOSWA4IRT9, THII_GEOTNQ7VKR6, THII_HAEDU
Q4QKG3, THII_HAEI8A5UC48, THII_HAEIEA5UEV3, THII_HAEIG
Q9K804, THII_HALH5B8D0L5, THII_HALOHB0R5A9, THII_HALS3
Q9HQ72, THII_HALSAQ0I3G4, THII_HISS1B0UUA1, THII_HISS2
B5Y0W8, THII_KLEP3A6T5F6, THII_KLEP7Q5FKW9, THII_LACAC
B3WDV9, THII_LACCBQ04B89, THII_LACDBC4Z0P7, THII_LACE2
Q042N0, THII_LACGAA8YUL5, THII_LACH4Q74K02, THII_LACJO
Q9CII1, THII_LACLAA2RIA6, THII_LACLMQ039U0, THII_LACP3
A9KKT0, THII_LACP7Q88UX4, THII_LACPLQ38XD3, THII_LATSS
Q03R12, THII_LEVBAQ1WT71, THII_LIGS1B2GAZ4, THII_LIMF3
A5VIU7, THII_LIMRDB2G6C3, THII_LIMRJQ92BB6, THII_LISIN
C1KVN9, THII_LISMCQ71Z75, THII_LISMFB8DHE9, THII_LISMH
Q8Y6U0, THII_LISMOA0AJ41, THII_LISW6B1HX36, THII_LYSSC
B9E7C5, THII_MACCJQ8EVH8, THII_MALP2Q65TP1, THII_MANSM
A1U6U9, THII_MARN8B3PLZ2, THII_META1Q8TQS4, THII_METAC
Q58341, THII_METJAQ8PU39, THII_METMAA5UKU4, THII_METS3
O27720, THII_METTHQ2RM06, THII_MOOTAA5IXS0, THII_MYCAP
P47612, THII_MYCGEP75228, THII_MYCPNQ98PK4, THII_MYCPU
Q4A5Q7, THII_MYCS5B2A8M8, THII_NATTJQ5YY71, THII_NOCFA
Q8EPB3, THII_OCEIHP57849, THII_PASMUQ6D841, THII_PECAS
C6DB40, THII_PECCPQ03EN8, THII_PEDPAQ7N0J9, THII_PHOLL
Q6LU02, THII_PHOPRB4EU34, THII_PROMHA6VDN5, THII_PSEA7
B7V3L1, THII_PSEA8Q02EP8, THII_PSEABQ9HU66, THII_PSEAE
C3K7D0, THII_PSEFSA4XZX0, THII_PSEMYQ3KJG6, THII_PSEPF
Q88CY4, THII_PSEPKQ88AM9, THII_PSESMQ4ZLX9, THII_PSEU2
A1SWV3, THII_PSYINQ8ZT61, THII_PYRAEQ21NG2, THII_SACD2
Q980G6, THII_SACS2B5EXG6, THII_SALA4A9MM39, THII_SALAR
Q57SD9, THII_SALCHB5FKT0, THII_SALDCB5QTH3, THII_SALEP
B5R6S6, THII_SALG2B4T8R6, THII_SALHSB4SWR7, THII_SALNS
Q5PFQ4, THII_SALPAA9MX06, THII_SALPBC0Q7V0, THII_SALPC
B5BDA7, THII_SALPKB4TMA5, THII_SALSVQ8Z8X1, THII_SALTI
P55913, THII_SALTYA8GAP5, THII_SERP5A1S8C9, THII_SHEAM
B8EAU2, THII_SHEB2A3D2B7, THII_SHEB5A6WL09, THII_SHEB8
A9KTM0, THII_SHEB9Q12L31, THII_SHEDOQ07ZD9, THII_SHEFN
B0TQ31, THII_SHEHHA3QGN4, THII_SHELPQ8EGR4, THII_SHEON
A8H6W6, THII_SHEPAA4Y4X5, THII_SHEPCB8CQH4, THII_SHEPW
A0KZA4, THII_SHESAA8FYK5, THII_SHESHQ0HGM0, THII_SHESM
Q0HSX1, THII_SHESRA1RLU8, THII_SHESWB1KQY3, THII_SHEWM
B2U4M7, THII_SHIB3Q325H8, THII_SHIBSQ32JI1, THII_SHIDS
Q0T7G6, THII_SHIF8Q83SG1, THII_SHIFLQ3Z4Y6, THII_SHISS
Q5WEC6, THII_SHOC1Q2NV91, THII_SODGMA7X3E5, THII_STAA1
A6U2I2, THII_STAA2Q2FG23, THII_STAA3Q2FXL1, THII_STAA8
A5ITN8, THII_STAA9Q2YTF0, THII_STAABQ5HF59, THII_STAAC
A6QHP9, THII_STAAEQ931P5, THII_STAAMQ99TE8, THII_STAAN
Q6GFZ2, THII_STAARQ6G8L2, THII_STAASA8Z2N1, THII_STAAT
Q8NW49, THII_STAAWQ5HNJ0, THII_STAEQQ8CNW7, THII_STAES
Q4L756, THII_STAHJQ49YE8, THII_STAS1Q3K0E0, THII_STRA1
Q8E4F9, THII_STRA3Q8DYV1, THII_STRA5C0M8U4, THII_STRE4
A8AWF4, THII_STRGCQ8DUR1, THII_STRMUQ9A0D8, THII_STRP1
Q04L36, THII_STRP2P0DF94, THII_STRP3B5E3Y2, THII_STRP4
Q5XCT0, THII_STRP6C1C6L4, THII_STRP7Q8P1G9, THII_STRP8
Q1JCG0, THII_STRPBQ1JMD8, THII_STRPCQ1JHI4, THII_STRPD
Q1J7A5, THII_STRPFA2RF72, THII_STRPGB1IB49, THII_STRPI
B8ZNS6, THII_STRPJQ48U81, THII_STRPMQ97RE1, THII_STRPN
P0DF95, THII_STRPQB2IP11, THII_STRPSB5XKV0, THII_STRPZ
Q8DQ92, THII_STRR6A4W0P5, THII_STRS2C0MGK8, THII_STRS7
A3CMR7, THII_STRSVA4VUF4, THII_STRSYB9DU51, THII_STRU0
C1CDN0, THII_STRZJC1CJW9, THII_STRZPC1CS14, THII_STRZT
Q4J6G3, THII_SULACC3MZC6, THII_SULIAC4KIK6, THII_SULIK
C3MR91, THII_SULILC3MXI0, THII_SULIMC3NG28, THII_SULIN
C3N7E8, THII_SULIYQ96YE5, THII_SULTOQ9HKT9, THII_THEAC
Q5JCY1, THII_THEKOQ9X220, THII_THEMAB0K8J2, THII_THEP3
B0K3I5, THII_THEPXQ72HP1, THII_THET2Q5SHD4, THII_THET8
Q97AK6, THII_THEVOC4LAC1, THII_TOLATO83570, THII_TREPA
B2S3F1, THII_TREPSB1AJ58, THII_UREP2Q9PQ71, THII_UREPA
B5ZBR5, THII_UREU1B7VJ96, THII_VIBA3A7MYC5, THII_VIBC1
Q9KTK8, THII_VIBCHQ87RT6, THII_VIBPAQ8DFA8, THII_VIBVU
Q7MN44, THII_VIBVYA1JNR2, THII_YERE8A7FLE0, THII_YERP3
Q1C4J3, THII_YERPAB2K6U1, THII_YERPBQ8ZC49, THII_YERPE
A9QZR9, THII_YERPGQ1CL83, THII_YERPNA4TPF8, THII_YERPP
Q66DV0, THII_YERPSB1JID5, THII_YERPY

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.8.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.8.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-