ID   2.8.1.4
DE   tRNA uracil 4-sulfurtransferase.
AN   tRNA sulfurtransferase.
CA   [ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA +
CA   ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = [ThiI sulfur-carrier
CA   protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate +
CA   2 oxidized [2Fe-2S]-[ferredoxin].
CC   -!- The enzyme, found in bacteria and archaea, is activated by
CC       EC 2.8.1.7, which transfers a sulfur atom to an internal L-cysteine
CC       residue, forming a cysteine persulfide.
CC   -!- The activated enzyme then transfers the sulfur to a uridine in a tRNA
CC       chain in a reaction that requires ATP.
CC   -!- The enzyme from the bacterium Escherichia coli forms 4-thiouridine
CC       only at position 8 of tRNA.
CC   -!- The enzyme also participates in the biosynthesis of the thiazole
CC       moiety of thiamine, but different domains are involved in the two
CC       processes.
DR   A3DEB6, THII_ACET2 ;  A9NHG7, THII_ACHLI ;  A6VQ53, THII_ACTSZ ;
DR   A0KIY0, THII_AERHH ;  Q9YEW8, THII_AERPE ;  A4SP64, THII_AERS4 ;
DR   C4ZAY9, THII_AGARV ;  Q5E6Y5, THII_ALIF1 ;  B5FBH1, THII_ALIFM ;
DR   B6EIB2, THII_ALISL ;  A6TQ96, THII_ALKMQ ;  A8MHS1, THII_ALKOO ;
DR   B7GGQ4, THII_ANOFW ;  O29382, THII_ARCFU ;  C1DHW2, THII_AZOVD ;
DR   C3PBB3, THII_BACAA ;  C3L9V4, THII_BACAC ;  A0RJN9, THII_BACAH ;
DR   Q81KU0, THII_BACAN ;  B7JS23, THII_BACC0 ;  Q72Z85, THII_BACC1 ;
DR   B7IK47, THII_BACC2 ;  C1EUZ5, THII_BACC3 ;  B7H703, THII_BACC4 ;
DR   B7HSI4, THII_BACC7 ;  A7GTS8, THII_BACCN ;  B9J151, THII_BACCQ ;
DR   Q817B1, THII_BACCR ;  Q633E8, THII_BACCZ ;  Q6HCN0, THII_BACHK ;
DR   Q65G52, THII_BACLD ;  A8FG94, THII_BACP2 ;  O34595, THII_BACSU ;
DR   A7Z7N3, THII_BACVZ ;  Q493G5, THII_BLOPB ;  C0ZH32, THII_BREBN ;
DR   Q8R9F0, THII_CALS4 ;  A8AK31, THII_CITK8 ;  Q97EY4, THII_CLOAB ;
DR   B2UX29, THII_CLOBA ;  Q189U8, THII_CLOD6 ;  B9DZV9, THII_CLOK1 ;
DR   A5N6D9, THII_CLOK5 ;  Q0TQI5, THII_CLOP1 ;  Q8XKI3, THII_CLOPE ;
DR   Q0ST36, THII_CLOPS ;  Q487C7, THII_COLP3 ;  Q83CD9, THII_COXBU ;
DR   B8D4I6, THII_DESA1 ;  A7ZIH7, THII_ECO24 ;  B7UJP6, THII_ECO27 ;
DR   B7MD81, THII_ECO45 ;  B7L657, THII_ECO55 ;  Q8XE74, THII_ECO57 ;
DR   B5Z3S9, THII_ECO5E ;  B7NJ74, THII_ECO7I ;  B7MQD8, THII_ECO81 ;
DR   B7M3R2, THII_ECO8A ;  C4ZTI0, THII_ECOBW ;  B1XF11, THII_ECODH ;
DR   A7ZX76, THII_ECOHS ;  A1A892, THII_ECOK1 ;  Q8FKB7, THII_ECOL6 ;
DR   B1J026, THII_ECOLC ;  P77718, THII_ECOLI ;  B7N8X6, THII_ECOLU ;
DR   B6HZM6, THII_ECOSE ;  B1LJH3, THII_ECOSM ;  Q1RFB7, THII_ECOUT ;
DR   C5BCI2, THII_EDWI9 ;  Q82ZW3, THII_ENTFA ;  B2VHS0, THII_ERWT9 ;
DR   B7LMG4, THII_ESCF3 ;  B0RZV0, THII_FINM2 ;  Q5KW56, THII_GEOKA ;
DR   C5D693, THII_GEOSW ;  A4IRT9, THII_GEOTN ;  Q7VKR6, THII_HAEDU ;
DR   Q4QKG3, THII_HAEI8 ;  A5UC48, THII_HAEIE ;  A5UEV3, THII_HAEIG ;
DR   Q9K804, THII_HALH5 ;  B8D0L5, THII_HALOH ;  B0R5A9, THII_HALS3 ;
DR   Q9HQ72, THII_HALSA ;  Q0I3G4, THII_HISS1 ;  B0UUA1, THII_HISS2 ;
DR   B5Y0W8, THII_KLEP3 ;  A6T5F6, THII_KLEP7 ;  Q5FKW9, THII_LACAC ;
DR   B3WDV9, THII_LACCB ;  Q04B89, THII_LACDB ;  C4Z0P7, THII_LACE2 ;
DR   Q042N0, THII_LACGA ;  A8YUL5, THII_LACH4 ;  Q74K02, THII_LACJO ;
DR   Q9CII1, THII_LACLA ;  A2RIA6, THII_LACLM ;  Q039U0, THII_LACP3 ;
DR   A9KKT0, THII_LACP7 ;  Q88UX4, THII_LACPL ;  Q38XD3, THII_LATSS ;
DR   Q03R12, THII_LEVBA ;  Q1WT71, THII_LIGS1 ;  B2GAZ4, THII_LIMF3 ;
DR   A5VIU7, THII_LIMRD ;  B2G6C3, THII_LIMRJ ;  Q92BB6, THII_LISIN ;
DR   C1KVN9, THII_LISMC ;  Q71Z75, THII_LISMF ;  B8DHE9, THII_LISMH ;
DR   Q8Y6U0, THII_LISMO ;  A0AJ41, THII_LISW6 ;  B1HX36, THII_LYSSC ;
DR   B9E7C5, THII_MACCJ ;  Q8EVH8, THII_MALP2 ;  Q65TP1, THII_MANSM ;
DR   A1U6U9, THII_MARN8 ;  B3PLZ2, THII_META1 ;  Q8TQS4, THII_METAC ;
DR   Q58341, THII_METJA ;  Q8PU39, THII_METMA ;  A5UKU4, THII_METS3 ;
DR   O27720, THII_METTH ;  Q2RM06, THII_MOOTA ;  A5IXS0, THII_MYCAP ;
DR   P47612, THII_MYCGE ;  P75228, THII_MYCPN ;  Q98PK4, THII_MYCPU ;
DR   Q4A5Q7, THII_MYCS5 ;  B2A8M8, THII_NATTJ ;  Q5YY71, THII_NOCFA ;
DR   Q8EPB3, THII_OCEIH ;  P57849, THII_PASMU ;  Q6D841, THII_PECAS ;
DR   C6DB40, THII_PECCP ;  Q03EN8, THII_PEDPA ;  Q7N0J9, THII_PHOLL ;
DR   Q6LU02, THII_PHOPR ;  B4EU34, THII_PROMH ;  A6VDN5, THII_PSEA7 ;
DR   B7V3L1, THII_PSEA8 ;  Q02EP8, THII_PSEAB ;  Q9HU66, THII_PSEAE ;
DR   C3K7D0, THII_PSEFS ;  A4XZX0, THII_PSEMY ;  Q3KJG6, THII_PSEPF ;
DR   Q88CY4, THII_PSEPK ;  Q88AM9, THII_PSESM ;  Q4ZLX9, THII_PSEU2 ;
DR   A1SWV3, THII_PSYIN ;  Q8ZT61, THII_PYRAE ;  Q21NG2, THII_SACD2 ;
DR   Q980G6, THII_SACS2 ;  B5EXG6, THII_SALA4 ;  A9MM39, THII_SALAR ;
DR   Q57SD9, THII_SALCH ;  B5FKT0, THII_SALDC ;  B5QTH3, THII_SALEP ;
DR   B5R6S6, THII_SALG2 ;  B4T8R6, THII_SALHS ;  B4SWR7, THII_SALNS ;
DR   Q5PFQ4, THII_SALPA ;  A9MX06, THII_SALPB ;  C0Q7V0, THII_SALPC ;
DR   B5BDA7, THII_SALPK ;  B4TMA5, THII_SALSV ;  Q8Z8X1, THII_SALTI ;
DR   P55913, THII_SALTY ;  A8GAP5, THII_SERP5 ;  A1S8C9, THII_SHEAM ;
DR   B8EAU2, THII_SHEB2 ;  A3D2B7, THII_SHEB5 ;  A6WL09, THII_SHEB8 ;
DR   A9KTM0, THII_SHEB9 ;  Q12L31, THII_SHEDO ;  Q07ZD9, THII_SHEFN ;
DR   B0TQ31, THII_SHEHH ;  A3QGN4, THII_SHELP ;  Q8EGR4, THII_SHEON ;
DR   A8H6W6, THII_SHEPA ;  A4Y4X5, THII_SHEPC ;  B8CQH4, THII_SHEPW ;
DR   A0KZA4, THII_SHESA ;  A8FYK5, THII_SHESH ;  Q0HGM0, THII_SHESM ;
DR   Q0HSX1, THII_SHESR ;  A1RLU8, THII_SHESW ;  B1KQY3, THII_SHEWM ;
DR   B2U4M7, THII_SHIB3 ;  Q325H8, THII_SHIBS ;  Q32JI1, THII_SHIDS ;
DR   Q0T7G6, THII_SHIF8 ;  Q83SG1, THII_SHIFL ;  Q3Z4Y6, THII_SHISS ;
DR   Q5WEC6, THII_SHOC1 ;  Q2NV91, THII_SODGM ;  A7X3E5, THII_STAA1 ;
DR   A6U2I2, THII_STAA2 ;  Q2FG23, THII_STAA3 ;  Q2FXL1, THII_STAA8 ;
DR   A5ITN8, THII_STAA9 ;  Q2YTF0, THII_STAAB ;  Q5HF59, THII_STAAC ;
DR   A6QHP9, THII_STAAE ;  Q931P5, THII_STAAM ;  Q99TE8, THII_STAAN ;
DR   Q6GFZ2, THII_STAAR ;  Q6G8L2, THII_STAAS ;  A8Z2N1, THII_STAAT ;
DR   Q8NW49, THII_STAAW ;  Q5HNJ0, THII_STAEQ ;  Q8CNW7, THII_STAES ;
DR   Q4L756, THII_STAHJ ;  Q49YE8, THII_STAS1 ;  Q3K0E0, THII_STRA1 ;
DR   Q8E4F9, THII_STRA3 ;  Q8DYV1, THII_STRA5 ;  C0M8U4, THII_STRE4 ;
DR   A8AWF4, THII_STRGC ;  Q8DUR1, THII_STRMU ;  Q9A0D8, THII_STRP1 ;
DR   Q04L36, THII_STRP2 ;  P0DF94, THII_STRP3 ;  B5E3Y2, THII_STRP4 ;
DR   Q5XCT0, THII_STRP6 ;  C1C6L4, THII_STRP7 ;  Q8P1G9, THII_STRP8 ;
DR   Q1JCG0, THII_STRPB ;  Q1JMD8, THII_STRPC ;  Q1JHI4, THII_STRPD ;
DR   Q1J7A5, THII_STRPF ;  A2RF72, THII_STRPG ;  B1IB49, THII_STRPI ;
DR   B8ZNS6, THII_STRPJ ;  Q48U81, THII_STRPM ;  Q97RE1, THII_STRPN ;
DR   P0DF95, THII_STRPQ ;  B2IP11, THII_STRPS ;  B5XKV0, THII_STRPZ ;
DR   Q8DQ92, THII_STRR6 ;  A4W0P5, THII_STRS2 ;  C0MGK8, THII_STRS7 ;
DR   A3CMR7, THII_STRSV ;  A4VUF4, THII_STRSY ;  B9DU51, THII_STRU0 ;
DR   C1CDN0, THII_STRZJ ;  C1CJW9, THII_STRZP ;  C1CS14, THII_STRZT ;
DR   Q4J6G3, THII_SULAC ;  C3MZC6, THII_SULIA ;  C4KIK6, THII_SULIK ;
DR   C3MR91, THII_SULIL ;  C3MXI0, THII_SULIM ;  C3NG28, THII_SULIN ;
DR   C3N7E8, THII_SULIY ;  Q96YE5, THII_SULTO ;  Q9HKT9, THII_THEAC ;
DR   Q5JCY1, THII_THEKO ;  Q9X220, THII_THEMA ;  B0K8J2, THII_THEP3 ;
DR   B0K3I5, THII_THEPX ;  Q72HP1, THII_THET2 ;  Q5SHD4, THII_THET8 ;
DR   Q97AK6, THII_THEVO ;  C4LAC1, THII_TOLAT ;  O83570, THII_TREPA ;
DR   B2S3F1, THII_TREPS ;  B1AJ58, THII_UREP2 ;  Q9PQ71, THII_UREPA ;
DR   B5ZBR5, THII_UREU1 ;  B7VJ96, THII_VIBA3 ;  A7MYC5, THII_VIBC1 ;
DR   Q9KTK8, THII_VIBCH ;  Q87RT6, THII_VIBPA ;  Q8DFA8, THII_VIBVU ;
DR   Q7MN44, THII_VIBVY ;  A1JNR2, THII_YERE8 ;  A7FLE0, THII_YERP3 ;
DR   Q1C4J3, THII_YERPA ;  B2K6U1, THII_YERPB ;  Q8ZC49, THII_YERPE ;
DR   A9QZR9, THII_YERPG ;  Q1CL83, THII_YERPN ;  A4TPF8, THII_YERPP ;
DR   Q66DV0, THII_YERPS ;  B1JID5, THII_YERPY ;
//