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ENZYME entry: EC 2.8.1.7

Accepted Name
Cysteine desulfurase.
Alternative Name(s)
Cysteine desulfurylase.
Reaction catalysed
L-cysteine + acceptor <=> L-alanine + S-sulfanyl-acceptor
Cofactor(s)
Pyridoxal 5'-phosphate.
Comment(s)
  • The sulfur from free L-cysteine is first transferred to a cysteine residue in the active site, and then passed on to various other acceptors.
  • The enzyme is involved in the biosynthesis of iron-sulfur clusters, thio-nucleosides in tRNA, thiamine, biotin, lipoate and pyranopterin (molybdopterin).
  • In Azotobacter vinelandii, this sulfur provides the inorganic sulfide required for nitrogenous metallocluster formation.
Cross-references
BRENDA2.8.1.7
EC2PDB2.8.1.7
ExplorEnz2.8.1.7
PRIAM enzyme-specific profiles2.8.1.7
KEGG Ligand Database for Enzyme Nomenclature2.8.1.7
IUBMB Enzyme Nomenclature2.8.1.7
IntEnz2.8.1.7
MEDLINEFind literature relating to 2.8.1.7
MetaCyc2.8.1.7
UniProtKB/Swiss-Prot
Q93WX6, CNIF1_ARATH;  O32975, CSD1_MYCLE;  Q49690, CSD2_MYCLE;  
Q46925, CSDA_ECOLI;  Q9YAB6, CSD_AERPE;  Q9K7A0, CSD_BACHD;  
O51111, CSD_BORBU;  Q9PLP0, CSD_CHLMU;  Q9Z7L5, CSD_CHLPN;  
O84693, CSD_CHLTR;  Q57476, CSD_HAEIN;  Q9HMM6, CSD_HALSA;  
O27442, CSD_METTH;  P63517, CSD_MYCBO;  Q49420, CSD_MYCGE;  
Q9KII6, CSD_MYCPA;  P75298, CSD_MYCPN;  P9WQ68, CSD_MYCTO;  
P9WQ69, CSD_MYCTU;  P57989, CSD_PASMU;  Q9HXX3, CSD_PSEAE;  
Q9Z408, CSD_PSEPK;  Q9V242, CSD_PYRAB;  Q5HHH0, CSD_STAAC;  
P63518, CSD_STAAM;  P99177, CSD_STAAN;  Q6GIH2, CSD_STAAR;  
Q6GB11, CSD_STAAS;  Q8NXH0, CSD_STAAW;  Q5HQQ0, CSD_STAEQ;  
Q8CTA4, CSD_STAES;  Q9XAD5, CSD_STRCO;  Q55793, CSD_SYNY3;  
Q9X191, CSD_THEMA;  O83623, CSD_TREPA;  Q9PQ36, CSD_UREPA;  
Q9KPQ7, CSD_VIBCH;  Q9PDA6, CSD_XYLFA;  Q87DJ2, CSD_XYLFT;  
O30052, ISCS1_ARCFU;  O34599, ISCS1_BACSU;  O29689, ISCS2_ARCFU;  
O34874, ISCS2_BACSU;  P9WQ70, ISCSL_MYCTO;  P9WQ71, ISCSL_MYCTU;  
B7H3H0, ISCS_ACIB3;  B7I5Q3, ISCS_ACIB5;  B2HZI5, ISCS_ACIBC;  
B0VNW2, ISCS_ACIBS;  B0VD51, ISCS_ACIBY;  A6VMN7, ISCS_ACTSZ;  
A0KJ32, ISCS_AERHH;  A4SP14, ISCS_AERS4;  B8JC53, ISCS_ANAD2;  
Q2INI7, ISCS_ANADE;  A7H804, ISCS_ANADF;  B4UCP2, ISCS_ANASK;  
C1DE68, ISCS_AZOVD;  O31269, ISCS_AZOVI;  B8D8F9, ISCS_BUCA5;  
P57657, ISCS_BUCAI;  O51886, ISCS_BUCAP;  B8D8B6, ISCS_BUCAT;  
Q89A19, ISCS_BUCBP;  A7FWJ9, ISCS_CLOB1;  A5I4Z9, ISCS_CLOBH;  
C1FTC4, ISCS_CLOBJ;  Q486Z0, ISCS_COLP3;  A7MGX8, ISCS_CROS8;  
Q47EN5, ISCS_DECAR;  B8DZS1, ISCS_DICTD;  A7ZPX4, ISCS_ECO24;  
B7UGX6, ISCS_ECO27;  B7MIM0, ISCS_ECO45;  B7LDC2, ISCS_ECO55;  
P0A6B9, ISCS_ECO57;  B5Z104, ISCS_ECO5E;  B7NRH9, ISCS_ECO7I;  
B7MYG3, ISCS_ECO81;  B7M7N3, ISCS_ECO8A;  C4ZXA5, ISCS_ECOBW;  
B1XB05, ISCS_ECODH;  A8A336, ISCS_ECOHS;  Q0TEV5, ISCS_ECOL5;  
P0A6B8, ISCS_ECOL6;  B1IWD1, ISCS_ECOLC;  P0A6B7, ISCS_ECOLI;  
B7N6B7, ISCS_ECOLU;  B6I5A2, ISCS_ECOSE;  B1LNI6, ISCS_ECOSM;  
C5BEU5, ISCS_EDWI9;  Q2GGJ4, ISCS_EHRCR;  A4WDB1, ISCS_ENT38;  
B2VI32, ISCS_ERWT9;  B7LKA9, ISCS_ESCF3;  Q7VMA9, ISCS_HAEDU;  
A5UAA8, ISCS_HAEIE;  A5UGI1, ISCS_HAEIG;  Q57337, ISCS_HAEIN;  
B8F356, ISCS_HAEPS;  Q0I1L2, ISCS_HAES1;  B6JKF2, ISCS_HELP2;  
Q9ZML2, ISCS_HELPJ;  B2US50, ISCS_HELPS;  O25008, ISCS_HELPY;  
B0UVL5, ISCS_HISS2;  B5XNJ7, ISCS_KLEP3;  A6TCF1, ISCS_KLEP7;  
Q65RS7, ISCS_MANSM;  Q60C64, ISCS_METCA;  Q1H361, ISCS_METFK;  
P57795, ISCS_METTE;  Q5F8X4, ISCS_NEIG1;  B4RMB8, ISCS_NEIG2;  
A9M029, ISCS_NEIM0;  Q9JTX0, ISCS_NEIMA;  Q9JYY0, ISCS_NEIMB;  
A1KUK1, ISCS_NEIMF;  P57803, ISCS_PASMU;  Q6D259, ISCS_PECAS;  
C6DBJ1, ISCS_PECCP;  Q7N224, ISCS_PHOLL;  Q6LU62, ISCS_PHOPR;  
B4EZU8, ISCS_PROMH;  Q48M05, ISCS_PSE14;  A6V0U8, ISCS_PSEA7;  
B7UWH7, ISCS_PSEA8;  Q02RW8, ISCS_PSEAB;  Q9HXI8, ISCS_PSEAE;  
Q1IEJ2, ISCS_PSEE4;  Q4K6T8, ISCS_PSEF5;  C3K1M5, ISCS_PSEFS;  
Q3IFI3, ISCS_PSEHT;  A4XY43, ISCS_PSEMY;  A5VYS4, ISCS_PSEP1;  
Q3K7A5, ISCS_PSEPF;  B0KPH6, ISCS_PSEPG;  Q88PK8, ISCS_PSEPK;  
B1JDR3, ISCS_PSEPW;  Q887A1, ISCS_PSESM;  Q4ZX34, ISCS_PSEU2;  
A4VNY2, ISCS_PSEU5;  A1SUI4, ISCS_PSYIN;  C3PNQ8, ISCS_RICAE;  
A8GNU0, ISCS_RICAH;  A8GWB2, ISCS_RICB8;  Q1RHY6, ISCS_RICBR;  
A8EYH9, ISCS_RICCK;  Q92HP1, ISCS_RICCN;  Q4UL77, ISCS_RICFE;  
A8F204, ISCS_RICM5;  Q9ZD60, ISCS_RICPR;  C4K1Z7, ISCS_RICPU;  
B0BXX6, ISCS_RICRO;  A8GSG4, ISCS_RICRS;  Q68WP6, ISCS_RICTY;  
O54055, ISCS_RUMFL;  A1AWM1, ISCS_RUTMC;  B5F1C0, ISCS_SALA4;  
A9MHJ4, ISCS_SALAR;  Q57LG9, ISCS_SALCH;  B5FR85, ISCS_SALDC;  
B5R5A2, ISCS_SALEP;  B5RD12, ISCS_SALG2;  B4TDB6, ISCS_SALHS;  
B4T0S2, ISCS_SALNS;  Q5PNG1, ISCS_SALPA;  A9N1X5, ISCS_SALPB;  
C0PYK7, ISCS_SALPC;  B5BAW6, ISCS_SALPK;  B4TRX5, ISCS_SALSV;  
Q8Z4N0, ISCS_SALTI;  Q8ZN40, ISCS_SALTY;  A8GHY3, ISCS_SERP5;  
A1S544, ISCS_SHEAM;  B8E9D2, ISCS_SHEB2;  A3D577, ISCS_SHEB5;  
A6WNY5, ISCS_SHEB8;  A9L3R0, ISCS_SHEB9;  Q12P83, ISCS_SHEDO;  
Q080P6, ISCS_SHEFN;  B0TNY1, ISCS_SHEHH;  A3QFD5, ISCS_SHELP;  
Q8EEU9, ISCS_SHEON;  A8H2M6, ISCS_SHEPA;  A4Y7D7, ISCS_SHEPC;  
B8CMW5, ISCS_SHEPW;  A0KXJ0, ISCS_SHESA;  A8FXA5, ISCS_SHESH;  
Q0HJF4, ISCS_SHESM;  Q0HVP4, ISCS_SHESR;  A1RJ52, ISCS_SHESW;  
B1KNI3, ISCS_SHEWM;  B2TXV5, ISCS_SHIB3;  Q0T1Y9, ISCS_SHIF8;  
P0A6C0, ISCS_SHIFL;  C4L7K2, ISCS_TOLAT;  A5CWM6, ISCS_VESOH;  
A5F3G4, ISCS_VIBC3;  A7MU48, ISCS_VIBCB;  Q9KTY2, ISCS_VIBCH;  
C3LT01, ISCS_VIBCM;  Q87S28, ISCS_VIBPA;  B7VJS6, ISCS_VIBTL;  
Q8DEY7, ISCS_VIBVU;  Q7MNG2, ISCS_VIBVY;  O49543, MNIF1_ARATH;  
P0DN31, NFS1_ARTBC;  O60028, NFS1_ASHGO;  P87185, NFS1_CANAL;  
P87187, NFS1_CANMA;  Q54X04, NFS1_DICDI;  Q9VKD3, NFS1_DROME;  
Q8SQS2, NFS1_ENCCU;  Q9Y697, NFS1_HUMAN;  Q9Z1J3, NFS1_MOUSE;  
Q5RDE7, NFS1_PONAB;  Q99P39, NFS1_RAT;  O74351, NFS1_SCHPO;  
B0YLW6, NFS1_TRAHO;  P25374, NFS1_YEAST;  Q44507, NIFS1_ANAVT;  
Q44482, NIFS2_ANAVT;  P70727, NIFS_AZOBR;  P23120, NIFS_AZOCH;  
P05341, NIFS_AZOVI;  Q9KDJ6, NIFS_BACHD;  P38033, NIFS_BACSU;  
P37030, NIFS_BRADU;  Q52069, NIFS_ENTAG;  Q9Z5X5, NIFS_FRASE;  
P57794, NIFS_GLUDA;  P05344, NIFS_KLEPN;  P12623, NIFS_NOSS1;  
Q07177, NIFS_RHOCA;  Q01179, NIFS_RHOSH;  P55690, NIFS_SINFN;  
Q43884, NIFS_TRIAZ;  O32164, SUFS_BACSU;  A8AH80, SUFS_CITK8;  
A7MF59, SUFS_CROS8;  Q9EXP2, SUFS_DICD3;  A7ZME5, SUFS_ECO24;  
B7US19, SUFS_ECO27;  B7MA32, SUFS_ECO45;  B7L5N2, SUFS_ECO55;  
Q7ADI4, SUFS_ECO57;  B5Z4B3, SUFS_ECO5E;  B7NTV6, SUFS_ECO7I;  
B7MV59, SUFS_ECO81;  B7M0N5, SUFS_ECO8A;  C4ZYE2, SUFS_ECOBW;  
B1XFY8, SUFS_ECODH;  A8A0M6, SUFS_ECOHS;  A1ABL8, SUFS_ECOK1;  
Q0THE9, SUFS_ECOL5;  Q8FH54, SUFS_ECOL6;  B1IQ76, SUFS_ECOLC;  
P77444, SUFS_ECOLI;  B7N516, SUFS_ECOLU;  B6IBB9, SUFS_ECOSE;  
B1LE56, SUFS_ECOSM;  Q1RBB6, SUFS_ECOUT;  A4W9R3, SUFS_ENT38;  
B7LQ96, SUFS_ESCF3;  D4GYV5, SUFS_HALVD;  B5XQH2, SUFS_KLEP3;  
A6TAE4, SUFS_KLEP7;  Q6D625, SUFS_PECAS;  C6DKM6, SUFS_PECCP;  
Q7N3U5, SUFS_PHOLL;  B5F7C4, SUFS_SALA4;  A9MEP3, SUFS_SALAR;  
Q57PR2, SUFS_SALCH;  B5FIM3, SUFS_SALDC;  B5QVS9, SUFS_SALEP;  
B5RAT4, SUFS_SALG2;  B4TGK9, SUFS_SALHS;  B4T4R6, SUFS_SALNS;  
A9N142, SUFS_SALPB;  B4TUT5, SUFS_SALSV;  Q8XF77, SUFS_SALTI;  
Q7CQN5, SUFS_SALTY;  A8GDU4, SUFS_SERP5;  B2U2I4, SUFS_SHIB3;  
Q321D9, SUFS_SHIBS;  Q7UAH4, SUFS_SHIFL;  Q3Z233, SUFS_SHISS;  
Q8D2J7, SUFS_WIGBR;  A7FHJ2, SUFS_YERP3;  Q1C761, SUFS_YERPA;  
B2K5J4, SUFS_YERPB;  Q8D0M6, SUFS_YERPE;  A9QZC9, SUFS_YERPG;  
Q1CIJ6, SUFS_YERPN;  A4TIP2, SUFS_YERPP;  Q66A22, SUFS_YERPS;  
B1JJ48, SUFS_YERPY;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.8.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.8.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-