ID   2.8.2.23
DE   [heparan sulfate]-glucosamine 3-sulfotransferase 1.
AN   3'-phosphoadenylyl-sulfate:heparin-glucosamine 3-O-sulfotransferase.
AN   3-OST-1.
AN   glucosaminyl 3-O-sulfotransferase.
AN   heparan sulfate D-glucosaminyl 3-O-sulfotransferase.
AN   heparin-glucosamine 3-O-sulfotransferase.
CA   3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) =
CA   3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine
CA   3',5'-bisphosphate + H(+).
CC   -!- This enzyme differs from EC 2.8.2.29 and EC 2.8.2.30 by being the
CC       most selective for a precursor of the antithrombin-binding site.
CC   -!- It has a minimal acceptor sequence of: -> GlcNAc6S->GlcA->
CC       GlcN2S*+-6S->IdoA2S->GlcN2S->.
CC   -!- It can also modify other precursor sequences within heparan sulfate
CC       but this action does not create functional antithrombin-binding
CC       sites.
CC   -!- These precursors are variants of the consensus sequence: ->
CC       Glc(N2S>NAc)+-6S->GlcA->GlcN2S*+-6S->GlcA>IdoA+-2S->
CC       Glc(N2S/NAc)+-6S->.
CC   -!- If the heparan sulfate substrate lacks 2-O-sulfation of GlcA
CC       residues, then enzyme specificity is expanded to modify selected
CC       glucosamine residues preceded by IdoA as well as GlcA.
DR   O14792, HS3S1_HUMAN;  O35310, HS3S1_MOUSE;  Q9ESG5, HS3S1_RAT  ;
DR   Q9Y661, HS3S4_HUMAN;  Q8IZT8, HS3S5_HUMAN;  Q8BSL4, HS3S5_MOUSE;
DR   Q96QI5, HS3S6_HUMAN;  Q5GFD5, HS3S6_MOUSE;  Q8BKN6, HS3SA_MOUSE;
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