ENZYME entry: EC 2.8.2.33

Accepted Name
N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase.
Alternative Name(s)
GalNAc4S-6ST.
Reaction catalysed
  • 3-phospho-5-adenylyl sulfate + [dermatan]-4-O-sulfo-N-acetylgalactosamine <=> adenosine 3',5'-bisphosphate + [dermatan]-4,6-di-O-sulfo-N-acetyl-D-galactosamine
  • 3-phospho-5-adenylyl sulfate + [chondroitin]-4-O-sulfo-N-acetylgalactosamine <=> adenosine 3',5'-bisphosphate + [chondroitin]-4,6-di-O-sulfo-N-acetyl-D-galactosamine
Comment(s)
  • The enzyme from human transfers sulfate to position 6 of both internal residues and non-reducing terminal GalNAc 4-sulfate residues of chondroitin sulfate.
  • Oligosaccharides derived from chondroitin sulfate also serve as acceptors but chondroitin sulfate E, keratan sulfate and heparan sulfate do not.
  • Differs from EC 2.8.2.17 in being able to use both chondroitin and dermatan as effective substrates.
Cross-references
BRENDA2.8.2.33
EC2PDB2.8.2.33
ExplorEnz2.8.2.33
PRIAM enzyme-specific profiles2.8.2.33
KEGG Ligand Database for Enzyme Nomenclature2.8.2.33
IUBMB Enzyme Nomenclature2.8.2.33
IntEnz2.8.2.33
MEDLINEFind literature relating to 2.8.2.33
MetaCyc2.8.2.33
UniProtKB/Swiss-Prot
Q7LFX5, CHSTF_HUMAN;  Q91XQ5, CHSTF_MOUSE;  Q8WTN9, CHSTF_NOTSL;  
Q8CHI9, CHSTF_RAT;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.8.2.-
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