ENZYME entry: EC 2.8.2.35

Accepted Name
Dermatan 4-sulfotransferase.
Alternative Name(s)
CHST14 protein.
Dermatan N-acetylgalactosamine 4-O-sulfotransferase.
Dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase.
Reaction catalysed
3'-phospho-5'-adenylyl sulfate + [dermatan]-N-acetyl-D-galactosamine <=> adenosine 3',5'-bisphosphate + [dermatan]- 4-O-sulfo-N-acetyl-D-galactosamine
Comment(s)
  • The sulfation takes place at the 4-position of N-acetylgalactosamine residues of dermatan.
  • D4ST-1 shows a strong preference in vitro for sulfate transfer to IdoUA-alpha(1,3)GalNAc-beta(1,4) that is flanked by GlcUA- beta(1,3)GalNAc-beta(1,4) as compared with IdoUA-alpha(1,3)GalNAc- beta(1,4) flanked by IdoUA-alpha(1,3)GalNAc-beta(1,4).
Cross-references
BRENDA2.8.2.35
EC2PDB2.8.2.35
ExplorEnz2.8.2.35
PRIAM enzyme-specific profiles2.8.2.35
KEGG Ligand Database for Enzyme Nomenclature2.8.2.35
IUBMB Enzyme Nomenclature2.8.2.35
IntEnz2.8.2.35
MEDLINEFind literature relating to 2.8.2.35
MetaCyc2.8.2.35
UniProtKB/Swiss-Prot
Q8NCH0, CHSTE_HUMAN;  Q80V53, CHSTE_MOUSE;  

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.8.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.8.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-