ENZYME entry: EC 2.8.2.8

Accepted Name
[Heparan sulfate]-glucosamine N-sulfotransferase.
Alternative Name(s)
3'-phosphoadenylyl-sulfate:heparitin N-sulfotransferase.
3'-phosphoadenylyl-sulfate:N-desulfoheparin N-sulfotransferase.
3'-phosphoadenylylsulfate:N-desulfoheparin sulfotransferase.
Desulfoheparin sulfotransferase.
Glucosaminyl N-deacetylase/N-sulfotransferase.
Heparan sulfate 2-N-sulfotransferase.
Heparan sulfate N-deacetylase/N-sulfotransferase.
Heparan sulfate N-sulfotransferase.
Heparan sulfate sulfotransferase.
Heparin N-sulfotransferase.
Heparitin sulfotransferase.
N-desulfoheparin sulfotransferase.
N-heparan sulfate sulfotransferase.
N-HSST.
PAPS:DSH sulfotransferase.
PAPS:N-desulfoheparin sulfotransferase.
Reaction catalysed
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine <=> adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
Comment(s)
  • The enzyme also catalyzes the sulfation of chondroitin 4-sulfate and dermatan sulfate, but to a much more limited extent.
  • Formerly EC 2.8.2.12.
Cross-references
BRENDA2.8.2.8
EC2PDB2.8.2.8
ExplorEnz2.8.2.8
PRIAM enzyme-specific profiles2.8.2.8
KEGG Ligand Database for Enzyme Nomenclature2.8.2.8
IUBMB Enzyme Nomenclature2.8.2.8
IntEnz2.8.2.8
MEDLINEFind literature relating to 2.8.2.8
MetaCyc2.8.2.8
UniProtKB/Swiss-Prot
P52848, NDST1_HUMAN;  Q3UHN9, NDST1_MOUSE;  Q02353, NDST1_RAT;  
Q6GQK9, NDST1_XENLA;  Q5U4X8, NDST1_XENTR;  O97583, NDST2_BOVIN;  
P52849, NDST2_HUMAN;  P52850, NDST2_MOUSE;  O95803, NDST3_HUMAN;  
Q9EQH7, NDST3_MOUSE;  Q9H3R1, NDST4_HUMAN;  Q9EQW8, NDST4_MOUSE;  
Q60V90, NDST_CAEBR;  Q966W3, NDST_CAEEL;  Q9V3L1, NDST_DROME;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.8.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.8.-.-
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