ID 2.8.3.24 DE (R)-2-hydroxy-4-methylpentanoate CoA-transferase. CA 4-methylpentanoyl-CoA + (2R)-hydroxy-4-methylpentanoate = (R)-2-hydroxy- CA 4-methylpentanoyl-CoA + 4-methylpentanoate. CC -!- The enzyme, characterized from the bacterium Peptoclostridium CC difficile, participates in an L-leucine fermentation pathway. CC -!- The reaction proceeds via formation of a covalent anhydride CC intermediate between a conserved aspartate residue and the acyl group CC of the CoA thioester substrate. DR Q5U921, HADA_CLODI ; //