ENZYME entry: EC 2.8.3.25

Accepted Name
Bile acid CoA-transferase.
Alternative Name(s)
Bile acid coenzyme A transferase.
Reaction catalysed
  • Lithocholoyl-CoA + cholate <=> lithocholate + choloyl-CoA
  • Deoxycholoyl-CoA + cholate <=> deoxycholate + choloyl-CoA
Comment(s)
  • The enzyme, characterized from the gut bacterium Clostridium scindens, catalyzes the last step in bile acid 7-alpha- dehydroxylation, the removal of the CoA moiety from the products.
  • By using a transferase rather than hydrolase, the bacteria conserve the thioester bond energy, saving ATP molecules.
  • The enzyme has a broad substrate specificity and can use multiple acceptors, including allocholate, ursodeoxycholate, and beta- muricholate.
  • Formerly EC 3.1.2.26.
Cross-references
BRENDA2.8.3.25
EC2PDB2.8.3.25
ExplorEnz2.8.3.25
PRIAM enzyme-specific profiles2.8.3.25
KEGG Ligand Database for Enzyme Nomenclature2.8.3.25
IUBMB Enzyme Nomenclature2.8.3.25
IntEnz2.8.3.25
MEDLINEFind literature relating to 2.8.3.25
MetaCyc2.8.3.25
UniProtKB/Swiss-Prot
P19413, BAIF_CLOSV

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