ID   2.8.4.1
DE   Coenzyme-B sulfoethylthiotransferase.
AN   Methyl coenzyme M reductase.
AN   Methyl-CoM reductase.
CA   Methyl-CoM + CoB = CoM-S-S-CoB + methane.
CF   Coenzyme F430.
CC   -!- This enzyme catalyzes the final step in methanogenesis,
CC       the biological production of methane.
CC   -!- This important anaerobic process is carried out only by methanogenic
CC       archaea.
CC   -!- The enzyme can also function in reverse, for anaerobic oxidation of
CC       methane.
CC   -!- The enzyme requires the hydroporphinoid nickel complex coenzyme
CC       F(430).
CC   -!- Highly specific for coenzyme B with a heptanoyl chain; ethyl CoM and
CC       difluoromethyl CoM are poor substrates.
CC   -!- The sulfide sulfur can be replaced by selenium but not by oxygen.
DR   P07962, MCRA_METBF ;  P12971, MCRA_METFE ;  Q58256, MCRA_METJA ;
DR   Q49605, MCRA_METKA ;  P22948, MCRA_METTE ;  O27232, MCRA_METTH ;
DR   P11558, MCRA_METTM ;  P07961, MCRA_METVA ;  P11559, MCRA_METVO ;
DR   P07955, MCRB_METBF ;  P12972, MCRB_METFE ;  Q58252, MCRB_METJA ;
DR   P22949, MCRB_METTE ;  O27236, MCRB_METTH ;  P11560, MCRB_METTM ;
DR   P07956, MCRB_METVA ;  P11561, MCRB_METVO ;  P07964, MCRG_METBF ;
DR   P12973, MCRG_METFE ;  Q58255, MCRG_METJA ;  P22950, MCRG_METTE ;
DR   O27233, MCRG_METTH ;  P11562, MCRG_METTM ;  P07963, MCRG_METVA ;
DR   P11563, MCRG_METVO ;  Q49174, MCRX_METFV ;  Q60391, MCRX_METJA ;
DR   P21110, MCRX_METTH ;  P58815, MCRX_METTM ;  Q49171, MCRY_METFV ;
DR   Q60390, MCRY_METJA ;  P21111, MCRY_METTH ;  Q49173, MCRZ_METFV ;
DR   Q60387, MCRZ_METJA ;  P21112, MCRZ_METTH ;  P58816, MCRZ_METTM ;
//