ENZYME entry: EC 2.9.1.1

Accepted Name
L-seryl-tRNA(Sec) selenium transferase.
Alternative Name(s)
Cysteinyl-tRNA(Sec)-selenium transferase.
Cysteinyl-tRNA(Sel)-selenium transferase.
L-selenocysteinyl-tRNA(Sec) synthase.
L-selenocysteinyl-tRNA(Sel) synthase.
Selenocysteine synthase.
Reaction catalysed
L-seryl-tRNA(Sec) + selenophosphate <=> L-selenocysteinyl-tRNA(Sec) + phosphate
Cofactor(s)
Pyridoxal 5'-phosphate.
Comment(s)
  • Recognizes specifically tRNA(Sec)-species.
  • Binding of tRNA(Sec) also occurs in the absence of the seryl group.
  • 2-aminoacryloyl-tRNA, bound to the enzyme as an imine with the pyridoxal phosphate, is an intermediate in the reaction.
  • Since the selenium atom replaces oxygen in serine, the product may also be referred to as L-selenoseryl-tRNA(Sel).
  • The abbreviation Sel has also been used for selenocysteine but Sec is preferred.
Cross-references
BRENDA2.9.1.1
EC2PDB2.9.1.1
ExplorEnz2.9.1.1
PRIAM enzyme-specific profiles2.9.1.1
KEGG Ligand Database for Enzyme Nomenclature2.9.1.1
IUBMB Enzyme Nomenclature2.9.1.1
IntEnz2.9.1.1
MEDLINEFind literature relating to 2.9.1.1
MetaCyc2.9.1.1
UniProtKB/Swiss-Prot
A3N2L0, SELA_ACTP2;  B3GYP5, SELA_ACTP7;  A6TQL2, SELA_ALKMQ;  
A8MHJ4, SELA_ALKOO;  O67140, SELA_AQUAE;  A8EV04, SELA_ARCB4;  
Q8R8W4, SELA_CALS4;  A7ZBQ0, SELA_CAMC1;  A0RR46, SELA_CAMFF;  
A8FN57, SELA_CAMJ8;  A7H1W2, SELA_CAMJD;  Q9PMS2, SELA_CAMJE;  
A1W0Z5, SELA_CAMJJ;  Q5HT33, SELA_CAMJR;  B9KDG5, SELA_CAMLR;  
Q3AB61, SELA_CARHZ;  A7FXT6, SELA_CLOB1;  C3L3I3, SELA_CLOB6;  
A5I656, SELA_CLOBH;  C1FVV5, SELA_CLOBJ;  B1ILX5, SELA_CLOBK;  
A7GHJ2, SELA_CLOBL;  B1KZQ3, SELA_CLOBM;  Q0TNJ4, SELA_CLOP1;  
Q8XIK2, SELA_CLOPE;  Q0SR63, SELA_CLOPS;  C6BW42, SELA_DESAD;  
B1I3P6, SELA_DESAP;  P56372, SELA_DESBA;  B8J1N0, SELA_DESDA;  
C4XIH0, SELA_DESMR;  Q6AMK5, SELA_DESPS;  P61735, SELA_DESVH;  
A7ZTD9, SELA_ECO24;  B7ULF0, SELA_ECO27;  B7MFF5, SELA_ECO45;  
B7L708, SELA_ECO55;  P0A822, SELA_ECO57;  B5YW91, SELA_ECO5E;  
B7NP97, SELA_ECO7I;  B7N237, SELA_ECO81;  B7M3L6, SELA_ECO8A;  
C4ZXI2, SELA_ECOBW;  A8A651, SELA_ECOHS;  A1AHD0, SELA_ECOK1;  
Q0TBL4, SELA_ECOL5;  Q8FCC1, SELA_ECOL6;  B1IZK2, SELA_ECOLC;  
P0A821, SELA_ECOLI;  B7NEP6, SELA_ECOLU;  B6I3G5, SELA_ECOSE;  
B1LK21, SELA_ECOSM;  Q1R503, SELA_ECOUT;  C5BC01, SELA_EDWI9;  
B7LTJ8, SELA_ESCF3;  Q9S3K3, SELA_EUBAC;  B9LZW4, SELA_GEODF;  
Q39ZL4, SELA_GEOMG;  P61736, SELA_GEOSL;  A5G937, SELA_GEOUR;  
Q7VKC2, SELA_HAEDU;  Q4QML1, SELA_HAEI8;  A5UE18, SELA_HAEIE;  
P43910, SELA_HAEIN;  B8F738, SELA_HAEPS;  Q7VI68, SELA_HELHP;  
B6JP11, SELA_HELP2;  Q9ZJA7, SELA_HELPJ;  O26043, SELA_HELPY;  
Q0BZB0, SELA_HYPNA;  B5XMW1, SELA_KLEP3;  A6TFJ1, SELA_KLEP7;  
Q65Q15, SELA_MANSM;  B8ES25, SELA_METSB;  Q2RFK3, SELA_MOOTA;  
O33277, SELA_MOOTH;  B9L5S9, SELA_NAUPA;  A1AYS1, SELA_PARDP;  
Q9CK66, SELA_PASMU;  Q7MY02, SELA_PHOLL;  B4F0S0, SELA_PROMH;  
A6VCR3, SELA_PSEA7;  B7V1L9, SELA_PSEA8;  Q02FL3, SELA_PSEAB;  
Q9HV01, SELA_PSEAE;  Q1IFP3, SELA_PSEE4;  A5VXT7, SELA_PSEP1;  
B0KKB9, SELA_PSEPG;  Q88QJ8, SELA_PSEPK;  B1J347, SELA_PSEPW;  
A4VFW8, SELA_PSEU5;  P58226, SELA_RHIME;  B5EX94, SELA_SALA4;  
A9MLE0, SELA_SALAR;  Q57IE9, SELA_SALCH;  B5FLG0, SELA_SALDC;  
B5R5B6, SELA_SALEP;  B5RGJ4, SELA_SALG2;  B4T974, SELA_SALHS;  
B4SWN1, SELA_SALNS;  Q5PLQ2, SELA_SALPA;  A9MVI1, SELA_SALPB;  
C0Q1E4, SELA_SALPC;  B5BHW8, SELA_SALPK;  B4TZT5, SELA_SALSV;  
Q8Z2D8, SELA_SALTI;  Q8ZL69, SELA_SALTY;  A8G7W0, SELA_SERP5;  
Q8EKI8, SELA_SHEON;  B2U5A3, SELA_SHIB3;  Q31V36, SELA_SHIBS;  
Q328Y9, SELA_SHIDS;  Q0SYB5, SELA_SHIF8;  Q83J28, SELA_SHIFL;  
Q3YVV3, SELA_SHISS;  Q30SC1, SELA_SULDN;  Q7M9L1, SELA_WOLSU;  
A1JT25, SELA_YERE8;  A7FP80, SELA_YERP3;  Q1C3H9, SELA_YERPA;  
B2K7H8, SELA_YERPB;  Q8Z9Y1, SELA_YERPE;  A9R4E4, SELA_YERPG;  
Q1CDA2, SELA_YERPN;  A4TGQ3, SELA_YERPP;  Q663U3, SELA_YERPS;  
B1JH26, SELA_YERPY;  

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