ENZYME entry: EC 3.1.1.64

Accepted Name
Retinoid isomerohydrolase.
Alternative Name(s)
All-trans-retinyl-palmitate hydrolase.
All-trans-retinylester 11-cis isomerohydrolase.
Reaction catalysed
An all-trans-retinyl ester + H(2)O <=> 11-cis-retinol + a fatty acid
Comment(s)
  • This enzyme, which operates in the retinal pigment epithelium (RPE), catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol, a key step in the regeneration of the visual chromophore in the vertebrate visual cycle.
  • Interaction of the enzyme with the membrane is critical for its enzymatic activity.
  • Formerly EC 5.2.1.7.
Cross-references
BRENDA3.1.1.64
EC2PDB3.1.1.64
ExplorEnz3.1.1.64
PRIAM enzyme-specific profiles3.1.1.64
KEGG Ligand Database for Enzyme Nomenclature3.1.1.64
IUBMB Enzyme Nomenclature3.1.1.64
IntEnz3.1.1.64
MEDLINEFind literature relating to 3.1.1.64
MetaCyc3.1.1.64
UniProtKB/Swiss-Prot
Q6PBW5, RP65A_DANRE;  A9C3R8, RP65C_DANRE;  Q9YI25, RPE65_AMBTI;  
Q28175, RPE65_BOVIN;  Q9TVB8, RPE65_CANLF;  Q9YGX2, RPE65_CHICK;  
Q9XT71, RPE65_CHLAE;  Q8AXN9, RPE65_CYNPY;  Q16518, RPE65_HUMAN;  
Q91ZQ5, RPE65_MOUSE;  O70276, RPE65_RAT;  

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