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ENZYME entry: EC 3.1.1.77

Accepted Name
Acyloxyacyl hydrolase.
Reaction catalysed
3-(acyloxy)acyl group of bacterial toxin <=> 3-hydroxyacyl group of bacterial toxin + a fatty acid
Comment(s)
  • The substrate is lipid A on the reducing end of the toxic lipopolysaccharide (LPS) of Salmonella typhimurium and related organisms.
  • It consists of diglucosamine, beta-D-GlcN-(1->6)-D-GlcN, attached by glycosylation on O-6 of its non-reducing residue, phosphorylated on O-4 of this residue and on O-1 of its potentially reducing residue.
  • Both residues carry 3-(acyloxy)acyl groups on N-2 and O-3.
  • The enzyme from human leukocytes detoxifies the lipid by hydrolyzing the secondary acyl groups from O-3 of the 3-hydroxyacyl groups on the disaccharide (LPS).
  • It also possesses a wide range of phospholipase and acyltransferase activities (e.g. EC 3.1.1.4, EC 3.1.1.5, EC 3.1.1.32 and EC 3.1.1.52), hydrolyzing diacylglycerol and phosphatidyl compounds, but not triacylglycerols.
  • It has a preference for saturated C(12)-C(16) acyl groups.
Cross-references
BRENDA3.1.1.77
EC2PDB3.1.1.77
ExplorEnz3.1.1.77
PRIAM enzyme-specific profiles3.1.1.77
KEGG Ligand Database for Enzyme Nomenclature3.1.1.77
IUBMB Enzyme Nomenclature3.1.1.77
IntEnz3.1.1.77
MEDLINEFind literature relating to 3.1.1.77
MetaCyc3.1.1.77
UniProtKB/Swiss-Prot
P28039, AOAH_HUMAN;  O35298, AOAH_MOUSE;  O18823, AOAH_RABIT;  
Q7WD07, PAGL_BORBR;  Q9HVD1, PAGL_PSEAE;  

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