ID   3.1.1.79
DE   Hormone-sensitive lipase.
AN   HSL.
CA   (1) Diacylglycerol + H(2)O = monoacylglycerol + a carboxylate.
CA   (2) Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
CA   (3) Monoacylglycerol + H(2)O = glycerol + a carboxylate.
CC   -!- This enzyme is a serine hydrolase.
CC   -!- Compared with other lipases, hormone-sensitive lipase has a uniquely
CC       broad substrate specificity.
CC   -!- It hydrolyzes all acylglycerols (triacylglycerol, diacylglycerol and
CC       monoacylglycerol) as well as cholesteryl esters, steroid fatty acid
CC       esters, retinyl esters and p-nitrophenyl esters.
CC   -!- It exhibits a preference for the 1- or 3-ester bond of its
CC       acylglycerol substrate compared with the 2-ester bond.
CC   -!- The enzyme shows little preference for the fatty acids in the
CC       triacylglycerol, although there is some increase in activity with
CC       decreasing chain length.
CC   -!- The enzyme activity is increased in response to hormones that elevate
CC       intracellular levels of cAMP.
PR   PROSITE; PDOC00903;
DR   P16386, LIPS_BOVIN ;  Q05469, LIPS_HUMAN ;  P54310, LIPS_MOUSE ;
DR   Q68J42, LIPS_PIG   ;  P15304, LIPS_RAT   ;  Q9R101, LIPS_SPETR ;
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