ID   3.1.1.79
DE   hormone-sensitive lipase.
AN   HSL.
CA   (1) a diacylglycerol + H2O = a fatty acid + a monoacylglycerol + H(+).
CA   (2) a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).
CA   (3) a monoacylglycerol + H2O = a fatty acid + glycerol + H(+).
CC   -!- This enzyme is a serine hydrolase.
CC   -!- Compared with other lipases, hormone-sensitive lipase has a uniquely
CC       broad substrate specificity.
CC   -!- It hydrolyzes all acylglycerols (triacylglycerol, diacylglycerol and
CC       monoacylglycerol) as well as cholesteryl esters, steroid fatty acid
CC       esters, retinyl esters and p-nitrophenyl esters.
CC   -!- It exhibits a preference for the 1- or 3-ester bond of its
CC       acylglycerol substrate compared with the 2-ester bond.
CC   -!- The enzyme shows little preference for the fatty acids in the
CC       triacylglycerol, although there is some increase in activity with
CC       decreasing chain length.
CC   -!- The enzyme activity is increased in response to hormones that elevate
CC       intracellular levels of cAMP.
DR   Q802V6, ABH2A_DANRE;  Q05AK6, ABH2B_DANRE;  Q5EA42, ABHD2_BOVIN;
DR   P08910, ABHD2_HUMAN;  Q4R2Y9, ABHD2_MACFA;  Q9QXM0, ABHD2_MOUSE;
DR   P16386, LIPS_BOVIN ;  Q05469, LIPS_HUMAN ;  Q9R101, LIPS_ICTTR ;
DR   P54310, LIPS_MOUSE ;  Q68J42, LIPS_PIG   ;  P15304, LIPS_RAT   ;
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