ENZYME entry: EC 3.1.1.80

Accepted Name
Acetylajmaline esterase.
Alternative Name(s)
2-beta-(R)-17-O-acetylajmalan:acetylesterase.
AAE.
Acetylajmalan esterase.
Reaction catalysed
  • 17-O-acetylajmaline + H(2)O <=> ajmaline + acetate
  • 17-O-acetylnorajmaline + H(2)O <=> norajmaline + acetate
Comment(s)
  • Responsible for the last stages in the biosynthesis of the indole alkaloid ajmaline.
  • Highly specific for the substrates 17-O-acetylajmaline and 17-O- acetylnorajmaline as the structurally related acetylated alkaloids vinorine, vomilenine, 1,2-dihydrovomilenine and 1,2- dihydroraucaffricine cannot act as substrates.
Cross-references
BRENDA3.1.1.80
EC2PDB3.1.1.80
ExplorEnz3.1.1.80
PRIAM enzyme-specific profiles3.1.1.80
KEGG Ligand Database for Enzyme Nomenclature3.1.1.80
IUBMB Enzyme Nomenclature3.1.1.80
IntEnz3.1.1.80
MEDLINEFind literature relating to 3.1.1.80
MetaCyc3.1.1.80
UniProtKB/Swiss-Prot
Q3MKY2, AAE_RAUSE;  P86830, AAE_RAUVE;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.1.-
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