ID 3.1.1.81 DE quorum-quenching N-acyl-homoserine lactonase. AN acyl homoserine degrading enzyme. AN acyl-homoserine-lactone acylase. AN AHLase. AN AHL-degrading enzyme. AN AHL-inactivating enzyme. AN AHL lactonase. AN N-acyl homoserine lactonase. AN N-acyl homoserine lactone hydrolase. AN N-acyl-homoserine lactone lactonase. AN N-acyl-L-homoserine lactone hydrolase. AN quorum-quenching lactonase. AN quorum-quenching N-acyl homoserine lactone hydrolase. CA an N-acyl-L-homoserine lactone + H2O = an N-acyl-L-homoserine + H(+). CC -!- Acyl-homoserine lactones (AHLs) are produced by a number of bacterial CC species and are used by them to regulate the expression of virulence CC genes in a process known as quorum-sensing. CC -!- Each bacterial cell has a basal level of AHL and, once the population CC density reaches a critical level, it triggers AHL-signaling which, CC in turn, initiates the expression of particular virulence genes. CC -!- Plants or animals capable of degrading AHLs would have a therapeutic CC advantage in avoiding bacterial infection as they could prevent AHL- CC signaling and the expression of virulence genes in quorum-sensing CC bacteria. CC -!- N-(3-oxohexanoyl)-L-homoserine lactone, N-(3-oxododecanoyl)-L- CC homoserine lactone, N-butanoyl-L-homoserine lactone and CC N-(3-oxooctanoyl)-L-homoserine lactone can act as substrates. DR P0CJ63, AHLLA_BACTK; A9CKY2, AHLLB_AGRFC; B9JPK6, AHLLB_RHIR8; DR Q7D3U0, AHLLM_AGRFC; A8IQD2, AHLLM_AZOC5; Q1M813, AHLLM_RHIJ3; DR Q8VPD5, AHLLM_RHIRD; Q7X3T2, AHLL_ARTSP ; Q08GP4, AHLL_BACCE ; DR Q9L8R8, AHLL_BACSP ; Q7B8C3, AHLL_BACT3 ; Q7B8C5, AHLL_BACTA ; DR A3FJ64, AHLL_BACTU ; C6L862, AHLL_MICTS ; P27169, PON1_HUMAN ; DR P52430, PON1_MOUSE ; P27170, PON1_RABIT ; P55159, PON1_RAT ; DR Q58DS7, PON2_BOVIN ; P54832, PON2_CANLF ; Q15165, PON2_HUMAN ; DR Q62086, PON2_MOUSE ; Q6AXM8, PON2_RAT ; Q15166, PON3_HUMAN ; DR Q62087, PON3_MOUSE ; Q9BGN0, PON3_RABIT ; Q68FP2, PON3_RAT ; //