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ENZYME entry: EC 3.1.1.85

Accepted Name
Pimeloyl-[acyl-carrier protein] methyl ester esterase.
Reaction catalysed
Pimeloyl-[acyl-carrier protein] methyl ester + H(2)O <=> pimeloyl-[acyl-carrier protein] + methanol
Comment(s)
  • Involved in biotin biosynthesis in Gram-negative bacteria.
  • The enzyme exhibits carboxylesterase activity, particularly toward substrates with short acyl chains.
  • Even though the enzyme can interact with coenzyme A thioesters, the in vivo role of the enzyme is to hydrolyze the methyl ester of pimeloyl-[acyl carrier protein], terminating the part of the biotin biosynthesis pathway that is catalyzed by the fatty acid elongation enzymes.
Cross-references
BRENDA3.1.1.85
EC2PDB3.1.1.85
ExplorEnz3.1.1.85
PRIAM enzyme-specific profiles3.1.1.85
KEGG Ligand Database for Enzyme Nomenclature3.1.1.85
IUBMB Enzyme Nomenclature3.1.1.85
IntEnz3.1.1.85
MEDLINEFind literature relating to 3.1.1.85
MetaCyc3.1.1.85
UniProtKB/Swiss-Prot
A0KF11, BIOH_AERHH;  A4ST17, BIOH_AERS4;  B6EPQ0, BIOH_ALISL;  
Q5NZF6, BIOH_AROAE;  Q89A54, BIOH_BUCBP;  Q7NPW5, BIOH_CHRVO;  
A8AQW5, BIOH_CITK8;  A7MGD2, BIOH_CROS8;  A7ZSU1, BIOH_ECO24;  
B7UKB7, BIOH_ECO27;  B7MDN8, BIOH_ECO45;  B7L4T9, BIOH_ECO55;  
Q8X716, BIOH_ECO57;  B5YTW3, BIOH_ECO5E;  B7NMH7, BIOH_ECO7I;  
B7N145, BIOH_ECO81;  B7M1W8, BIOH_ECO8A;  C4ZUR7, BIOH_ECOBW;  
B1X758, BIOH_ECODH;  A8A5M0, BIOH_ECOHS;  A1AGT6, BIOH_ECOK1;  
Q0TC55, BIOH_ECOL5;  Q8FCT4, BIOH_ECOL6;  B1IP53, BIOH_ECOLC;  
P13001, BIOH_ECOLI;  B7NE17, BIOH_ECOLU;  B6I2X6, BIOH_ECOSE;  
B1LHL2, BIOH_ECOSM;  Q1R5M2, BIOH_ECOUT;  C5BGT3, BIOH_EDWI9;  
B7LSB5, BIOH_ESCF3;  C4K407, BIOH_HAMD5;  Q5QZC0, BIOH_IDILO;  
B5XTS4, BIOH_KLEP3;  A6TF35, BIOH_KLEP7;  Q5X590, BIOH_LEGPA;  
A5IBW4, BIOH_LEGPC;  Q5ZVG6, BIOH_LEGPH;  Q5WW99, BIOH_LEGPL;  
Q609V0, BIOH_METCA;  Q5F641, BIOH_NEIG1;  Q9JSN0, BIOH_NEIMA;  
Q9K197, BIOH_NEIMB;  A1KRU9, BIOH_NEIMF;  E6MWF8, BIOH_NEIMH;  
Q82SL8, BIOH_NITEU;  Q2Y9Y7, BIOH_NITMU;  Q6CZL9, BIOH_PECAS;  
C6DGH6, BIOH_PECCP;  Q7N9V7, BIOH_PHOLL;  Q6LVQ7, BIOH_PHOPR;  
B4EZM6, BIOH_PROMH;  Q15N09, BIOH_PSEA6;  B5F8M6, BIOH_SALA4;  
A9MMB5, BIOH_SALAR;  Q57IW5, BIOH_SALCH;  B5FJT1, BIOH_SALDC;  
B5R369, BIOH_SALEP;  B5R7K5, BIOH_SALG2;  B4TKT6, BIOH_SALHS;  
B4SVL3, BIOH_SALNS;  Q5PLY8, BIOH_SALPA;  C0Q0I5, BIOH_SALPC;  
B5BHG7, BIOH_SALPK;  Q8Z221, BIOH_SALTI;  Q8ZLI9, BIOH_SALTY;  
Q8GHL1, BIOH_SERMA;  A8GKT5, BIOH_SERP5;  Q8E8N6, BIOH_SHEON;  
Q0HPU6, BIOH_SHESR;  B1KM44, BIOH_SHEWM;  B2U3M2, BIOH_SHIB3;  
Q31VM0, BIOH_SHIBS;  Q32AM6, BIOH_SHIDS;  Q83PW0, BIOH_SHIFL;  
Q3YWL3, BIOH_SHISS;  Q2NQH6, BIOH_SODGM;  B4SM83, BIOH_STRM5;  
B2FLM6, BIOH_STRMK;  C4LA13, BIOH_TOLAT;  A7MST3, BIOH_VIBCB;  
Q9KNL4, BIOH_VIBCH;  Q5E8N3, BIOH_VIBF1;  B5FFE9, BIOH_VIBFM;  
Q87TC2, BIOH_VIBPA;  B7VHH1, BIOH_VIBTL;  Q8DDU4, BIOH_VIBVU;  
Q7MPY0, BIOH_VIBVY;  Q8D1X1, BIOH_WIGBR;  Q8PQE0, BIOH_XANAC;  
Q4UZP1, BIOH_XANC8;  B0RMQ9, BIOH_XANCB;  Q8PDF3, BIOH_XANCP;  
Q2P907, BIOH_XANOM;  Q5H6D1, BIOH_XANOR;  B2I9H6, BIOH_XYLF2;  
Q9PDM3, BIOH_XYLFA;  B0U6I9, BIOH_XYLFM;  Q87DT3, BIOH_XYLFT;  
A1JSF8, BIOH_YERE8;  A7FNV8, BIOH_YERP3;  B2K5V7, BIOH_YERPB;  
Q74Y45, BIOH_YERPE;  A9R4D0, BIOH_YERPG;  Q664J8, BIOH_YERPS;  
B1JHZ5, BIOH_YERPY;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-