ENZYME entry: EC 3.1.11.7

Accepted Name
Adenosine-5'-diphospho-5'-(DNA) diphosphatase.
Alternative Name(s)
5'-app5'-DNA adenylate hydrolase.
Aprataxin.
Reaction catalysed
  • Adenosine-5'-diphospho-5'-(DNA) + H(2)O <=> AMP + phospho-5'-(DNA)
  • Adenosine-5'-diphospho-5'-(ribonucleotide)-(DNA) + H(2)O <=> AMP + 5'-phospho-(ribonucleotide)-(DNA)
Comment(s)
  • Aprataxin is a DNA-binding protein involved in different types of DNA break repair.
  • The enzyme acts (among other activities) on abortive DNA ligation intermediates that contain an adenylate covalently linked to the 5'-phosphate DNA terminus.
  • It also acts when the adenylate is covalently linked to the 5'-phosphate of a ribonucleotide linked to a DNA strand, which is the result of abortive ligase activty on products of EC 3.1.26.4, an enzyme that cleaves RNA-DNA hybrids on the 5' side of the ribonucleotide found in the 5'-RNA-DNA-3' junction.
  • Aprataxin binds the adenylate group to a histidine residue within the active site, followed by its hydrolysis from the nucleic acid and eventual release, leaving a 5'-phosphate terminus that can be efficiently rejoined.
  • The enzyme also possesses the activities of EC 3.1.11.8 and EC 3.1.12.2.
Cross-references
BRENDA3.1.11.7
EC2PDB3.1.11.7
ExplorEnz3.1.11.7
PRIAM enzyme-specific profiles3.1.11.7
KEGG Ligand Database for Enzyme Nomenclature3.1.11.7
IUBMB Enzyme Nomenclature3.1.11.7
IntEnz3.1.11.7
MEDLINEFind literature relating to 3.1.11.7
MetaCyc3.1.11.7
UniProtKB/Swiss-Prot
Q7YRZ2, APTX_BOVIN;  P61797, APTX_CANLF;  P61798, APTX_CHICK;  
P61802, APTX_CIOIN;  P61799, APTX_DANRE;  Q7Z2E3, APTX_HUMAN;  
Q9BGQ0, APTX_MACFA;  Q7TQC5, APTX_MOUSE;  Q7YRZ1, APTX_PIG;  
Q8K4H4, APTX_RAT;  O74859, APTX_SCHPO;  P61800, APTX_TAKRU;  
Q7T287, APTX_XENLA;  P61801, APTX_XENTR;  Q08702, APTX_YEAST;  

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