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ENZYME entry: EC 126.96.36.199
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|Pp5'G5'-DNA guanylate hydrolase.|
|Guanosine-5'-diphospho-5'-(DNA) + H(2)O <=> phospho-5'-(DNA) + GMP|
- Aprataxin is a DNA-binding protein that catalyzes (among other
activities) the 5' decapping of Gpp-DNA (formed by homologs of RtcB3
from the bacterium Myxococcus xanthus).
- The enzyme binds the guanylate group to a histidine residue at its
active site, forming a covalent enzyme-nucleotide phosphate
intermediate, followed by the hydrolysis of the guanylate from the
nucleic acid and eventual release.
- The enzyme forms a 5'-phospho terminus that can be efficiently joined
by 'classical' ligases.
- The enzyme also possesses the activitiy of EC 188.8.131.52 and
|PRIAM enzyme-specific profiles||184.108.40.206|
|KEGG Ligand Database for Enzyme Nomenclature||220.127.116.11|
|IUBMB Enzyme Nomenclature||18.104.22.168|
|MEDLINE||Find literature relating to 22.214.171.124|
entries corresponding to 3.1.11.-
entries corresponding to 3.1.-.-
entries corresponding to 3.-.-.-