ENZYME entry: EC 3.1.12.2

Accepted Name
DNA-3'-diphospho-5'-guanosine diphosphatase.
Alternative Name(s)
Aprataxin.
DNA-3'pp5'G guanylate hydrolase.
Reaction catalysed
(DNA)-3'-diphospho-5'-guanosine + H(2)O <=> (DNA)-3'-phosphate + GMP
Comment(s)
  • Aprataxin is a DNA-binding protein that catalyzes (among other activities) the 3' decapping of DNA-ppG (formed by EC 6.5.1.8).
  • The enzyme binds the guanylate group to a histidine residue at its active site, forming a covalent enzyme-nucleotide phosphate intermediate, followed by the hydrolysis of the guanylate from the nucleic acid and its eventual release.
  • The enzyme also possesses the activity of EC 3.1.11.7 and EC 3.1.11.8.
Cross-references
BRENDA3.1.12.2
EC2PDB3.1.12.2
ExplorEnz3.1.12.2
PRIAM enzyme-specific profiles3.1.12.2
KEGG Ligand Database for Enzyme Nomenclature3.1.12.2
IUBMB Enzyme Nomenclature3.1.12.2
IntEnz3.1.12.2
MEDLINEFind literature relating to 3.1.12.2
MetaCyc3.1.12.2
UniProtKB/Swiss-Prot
Q7YRZ2, APTX_BOVIN;  P61797, APTX_CANLF;  P61798, APTX_CHICK;  
P61802, APTX_CIOIN;  P61799, APTX_DANRE;  Q7Z2E3, APTX_HUMAN;  
Q9BGQ0, APTX_MACFA;  Q7TQC5, APTX_MOUSE;  Q7YRZ1, APTX_PIG;  
Q8K4H4, APTX_RAT;  O74859, APTX_SCHPO;  P61800, APTX_TAKRU;  
Q7T287, APTX_XENLA;  P61801, APTX_XENTR;  Q08702, APTX_YEAST;  

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