ENZYME entry: EC 3.1.13.5

Accepted Name
Ribonuclease D.
Alternative Name(s)
RNase D.
Reaction catalysed
Exonucleolytic cleavage that removes extra residues from the 3'-terminus of tRNA to produce 5'-mononucleotides
Cofactor(s)
Mg(2+) or cobalt cation or Mn(2+).
Comment(s)
  • Alteration of the 3'-terminal base has no effect on the rate of hydrolysis whereas modification of the 3'-terminal sugar has a major effect.
  • tRNA terminating with a 3'-phosphate is completely inactive.
  • This enzyme can convert a tRNA precursor into a mature tRNA.
Cross-references
BRENDA3.1.13.5
EC2PDB3.1.13.5
ExplorEnz3.1.13.5
PRIAM enzyme-specific profiles3.1.13.5
KEGG Ligand Database for Enzyme Nomenclature3.1.13.5
IUBMB Enzyme Nomenclature3.1.13.5
IntEnz3.1.13.5
MEDLINEFind literature relating to 3.1.13.5
MetaCyc3.1.13.5
UniProtKB/Swiss-Prot
A5G127, RND_ACICJ;  Q6G329, RND_BARHE;  C9XUE4, RND_CROTZ;  
Q6AJF4, RND_DESPS;  C6C608, RND_DICDC;  P09155, RND_ECOLI;  
A9H9B7, RND_GLUDA;  Q0BVP4, RND_GRABC;  P44442, RND_HAEIN;  
Q28RA7, RND_JANSC;  B8EN54, RND_METSB;  Q1QLI8, RND_NITHX;  
A7HYE5, RND_PARL1;  A6V8R6, RND_PSEA7;  A1SVE6, RND_PSYIN;  
A8GFH0, RND_SERP5;  A0KXU5, RND_SHESA;  D4Z694, RND_SPHJU;  
Q5GZ75, RND_XANOR;  Q5NPM2, RND_ZYMMO;  

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