To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https

ENZYME entry: EC

Accepted Name
Choloyl-CoA hydrolase.
Alternative Name(s)
Chenodeoxycholoyl-coenzyme A thioesterase.
Choloyl-coenzyme A thioesterase.
Peroxisomal acyl-CoA thioesterase 2.
Reaction catalysed
Choloyl-CoA + H(2)O <=> cholate + CoA
  • Also acts on chenodeoxycholoyl-CoA and to a lesser extent on short- and medium- to long-chain acyl-CoA's, and other substrates, including trihydroxycoprostanoyl-CoA, hydroxymethylglutaryl-CoA and branched chain acyl-CoA's, all of which are present in peroxisomes.
  • The enzyme is strongly inhibited by CoA and may be involved in controlling CoA levels in the peroxisome.
PRIAM enzyme-specific profiles3.1.2.27
KEGG Ligand Database for Enzyme Nomenclature3.1.2.27
IUBMB Enzyme Nomenclature3.1.2.27
MEDLINEFind literature relating to
O14734, ACOT8_HUMAN;  P58137, ACOT8_MOUSE;  Q8VHK0, ACOT8_RAT;  

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-